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2 results on '"Nil Yakar"'

1. Possible Association between the Quantity of Peri-implant Crevicular Fluid, Clinical Indices, and the Dimensions of Endosseous Implants

Author

Onurcem Duruel, Samir Goyushov, Nil Yakar, Güliz Nigar Güncü, Erdem Karabulut, and Tolga Fikret Tözüm

Subjects
dental implants, diagnosis, gingival crevicular fluid, inflammation, Dentistry, RK1-715
Abstract

Objectives: The objectives of this clinical observational study are to measure peri-implant crevicular fluid volume based on dental implant diameter and length, and to evaluate the possible relationship between peri-implant crevicular fluid/gingival crevicular fluid volumes and clinical periodontal indices. Material and Methods: The information about length and diameter of dental implants was noted. Clinical indices (probing depth, plaque index, gingival bleeding time index, and gingival index) were recorded. Peri-implant crevicular fluid (PICF)/gingival crevicular fluid (GCF) volumes were measured from 4 sites (mesial, buccal, distal, and lingual/palatal) of each dental implant including its one or more equivalent natural tooth/teeth. Results: One-hundred-sixty-one loaded dental implants and 221 natural teeth of 101 patients were evaluated. The length of dental implant had no effect on PICF volume (P > 0.05). However, PICF volumes of narrow (< 3.5 mm) and wide (> 4.5 mm) diameter implants were higher than standard diameter implants (≥ 3.5 mm, and ≤ 4.5 mm) (P < 0.05). PICF and GCF volumes of areas with peri-implant/periodontal diseases were significantly higher than healthy areas (P < 0.05). PICF and GCF volumes showed positive correlations with clinical indices (P < 0.05). Conclusions: In accordance with the results of the present study, the implant diameter, not the implant length, affects peri-implant crevicular fluid volume.

Published
2022
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2. Evaluation of gingival crevicular fluid and peri-implant crevicular fluid levels of sclerostin, TWEAK, RANKL and OPG

Author

Nil Yakar, Erdem Karabulut, Rahime M. Nohutcu, Abdullah C. Akman, Asli Pinar, and Güliz N. Güncü

Subjects
0301 basic medicine, Adult, Male, Immunology, Dentistry, Biochemistry, Proinflammatory cytokine, Bone remodeling, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Osteoprotegerin, medicine, Immunology and Allergy, Humans, Molecular Biology, Gingival recession, Adaptor Proteins, Signal Transducing, Aged, Periodontitis, Dental Implants, biology, business.industry, RANK Ligand, Cytokine TWEAK, Hematology, Gingival Crevicular Fluid, Middle Aged, medicine.disease, Peri-Implantitis, 030104 developmental biology, chemistry, RANKL, 030220 oncology & carcinogenesis, biology.protein, Biomarker (medicine), Sclerostin, Female, medicine.symptom, business
Abstract

The combination of local and systemic factors play role in the pathogenesis of periodontal and peri-implant diseases. Host-derived enzymes, cytokines and other proinflammatory mediators play an integral role in this destruction. The aim of this study is to evaluate gingival crevicular fluid (GCF) and peri-implant crevicular (PICF) fluid levels of sclerostin, TNF-related weak inducer of apoptosis (TWEAK), receptor activator of nuclear factor kappa-beta ligand (RANKL) and osteoprotegerin OPG in periodontal and peri-implant tissues in disease and health conditions and also to assess the potential for use as biomarkers.The study population was consisted of 50 women and 41 men, in the total of 91 individuals, with a mean age of 51.84 ± 14.05. Periodontitis (n = 22), periodontal health (n = 17), peri-implantitis (n = 27) and peri-implant health (n = 25) groups were established according to clinical and radiographic examination results of 39 teeth and 52 implants restored with fixed prosthetic restorations. In all groups, periodontal and peri-implant parameters (probing depth, gingival recession, gingival bleeding time index, gingival index, and plaque index) were recorded and GCF and PICF samples were also collected. Sclerostin, TWEAK, RANKL and OPG levels in GCF and PICF were measured with ELISA tests.Peri-implantitis group presented significantly higher levels of Sclerostin (p = 0.002), TWEAK(p 0.0001), RANKL(p 0.0001), and OPG (p = 0.037) compared to peri-implant health group. Similarly, significantly higher levels of TWEAK (p = 0.001), RANKL(p 0.0001), and OPG(p = 0.025) were detected in periodontitis group when compared to periodontal health group. Statistically significant correlations were also noted between biochemical parameters and clinical parameters.Findings of this study evaluating four different bone metabolism related proteins at the same time, suggests levels of sclerostin may be a biomarker for peri-implant disease presenting significantly higher levels in the peri-implantitis group than in the peri-implant health group. Moreover, levels of TWEAK can be a good indicator for both periodontal and peri-implant disease, due to the correlations with periodontal clinical parameters and the higher levels of TWEAK in diseased sites compared to the healthy sites for both dental implants and teeth.

Published
2018

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