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This case report describes the clinical efficacy of treatment with basic fibroblast growth factor (FGF-2) for periodontal regeneration. A patient with aggressive periodontitis participated in a clinical trial involving administration of 0.3% FGF-2 in comparison with a placebo control. To evaluate the efficacy of FGF-2, standardized radiographs were taken before surgery and at 12, 24, and 36 weeks after FGF-2 treatment. The rate of increase in alveolar bone height was 86.9% at 36 weeks. The 6-year postoperative radiograph showed significant development of alveolar bone in comparison with the first visit. FGF-2 treatment may be effective for periodontal regeneration in cases of aggressive periodontitis. (J Oral Sci 58, 137-140, 2016).

Discrepancy in the labial gingival margin of the maxillary incisors poses a major aesthetic problem. Orthodontic extrusion can improve the aesthetic problem caused by gingival margin levels before restoration. In these case reports, orthodontic extrusion was performed with palatal circumferential supracrestal fiberotomy for improving the discrepancy of the labial gingival margin. Two years postoperatively, the position of the tooth and gingival margin remained stable. Orthodontic extrusion with palatal circumferential supracrestal fiberotomy was effective in improving the discrepancy of the labial gingival margin of maxillary incisors. (J Oral Sci 51, 651-654, 2009)

Invasive cervical root resorption is a relatively uncommon form of external root resorp- tion. Creeping attachment is defined as postoperative coronal migration of the gingival margin. We describe a case of invasive cervical root resorption following coronal shift of interdental papillae 15 years after modified Widman flap surgery. (J Oral Sci 55, 183-185, 2013)

毛の先端を高度テーパード毛にした新形態の歯ブラシを作製したものを使用し, プラーク除去効果を検討した。年齢23～52歳の男女75名を被験者に1日2回, 3分間以上, スクラップ法およびゴットリーブの垂直法を併用したブラッシング法を行わせた。すなわち, テスト期間を2週間とし被験者をスタート時のプラーク付着率および歯間空隙の大きさによって2群に分け, 被験者のプラークを除去した後, 高度テーパード毛歯ブラシおよびラウンド毛歯ブラシを用いて1週間ずつクロスして使用させた。それぞれ1週間後のブラッシング後のプラーク付着歯面数からプラーク付着率を算出しグループ間での比較検討を行った。その結果, 高度テーパード毛歯ブラシはラウンド毛歯ブラシよりプラーク除去効果は統計的に有意 (p

Iwano Y, Sugano N, Matsumoto K, Nishihara R, Iizuka T, Yoshinuma N, Ito K. Salivary microbial levels in relation to periodontal status and caries development. J Periodont Res 2010; 45: 165–169. © 2010 John Wiley & Sons A/S Background and Objective: Although an inverse relationship between caries and periodontal disease has been suggested, some studies have reported a positive correlation between periodontal disease and the decayed, missing and filled teeth (DMF) index. The aim of the present study was to examine the relationship between caries and periodontal disease. Material and Methods: We assessed the clinical parameters and salivary levels of Porphyromonas gingivalis and Streptococcus mutans using real-time polymerase chain reaction in 40 subjects with varying degrees of caries and periodontal disease. Results: The salivary levels of S. mutans were significantly higher in the periodontally healthy group than in the periodontitis group. The salivary levels of P. gingivalis were significantly higher in the caries-free group than in the periodontally healthy group with caries. The salivary levels of S. mutans were significantly increased after the initial periodontal treatment. Conclusions: This study showed that an inverse relationship exists between periodontitis and caries in terms of the clinical and bacteriological findings.

Long-term studies have indicated that alloplastic bone grafts composed of nonresorbable hydroxyapatite (NHA) are clinically stable and safe. However, our previous report suggested that NHA grafts may be an etiological factor for recurrent periodontitis in the absence of supportive periodontal treatment (SPT). We removed infected NHA from the root surface by flap surgery in two cases of recurrent periodontitis. After removal of the infected NHA, the inflammation subsided in these cases and they were clinically stable for several years. (J Oral Sci 51, 659-663, 2009)

本実験の目的は, 0.2%Chlorhexidine水溶液と0.01%Sanguinarine含有Viadent ® 洗口液および, その歯磨剤のプラーク抑制効果を検討することである。実験開始時にProfessionaltoothcleaningを行いプラーク量を0にし, 各自の口腔清掃法にViadent ® 洗口液10ml, 30秒間の洗口を朝夕2回加え, 2週目にPlaqueIndexを記録し, 洗口を中止した。2週後に再びプラーク量を0とし, 0.2% Chlorhexidine水溶液による洗口をViadent ® と同様に2週間行わせ, PlaqueIndexを記録した。再び洗口を中止し, 2週後にプラーク量を0とし, Viadent ® 洗口液10m1, 30秒間の洗口を1日5回, ブラッシング時にViadent ® 歯磨剤を併用させ2週後にPlaqueIndexを記録した。その結果, 各実験期間でプラーク抑制効果は有意に認められた。Chlorhexidineの効果は最も高かったが, 副作用が多く認められた。一方, Viadent ® 製剤の使用では副作用はほとんど認められなかった。

非付着性プラーク中の内毒素と臨床所見の関連性を検討するために, 49名の被験者の歯周疾患罹患歯64歯に対し, 歯肉縁下洗浄を行い, そのポケット洗浄液中の内毒素量を測定し, 臨床所見と比較した。また, スケーリング, ルートプレーニング後の歯肉縁下洗浄を行い, 臨床所見と内毒素量の変化を観察した。Westphahlらの温フェノールー水抽出法にて内毒素を抽出し, パイロディック®を用い, 定量を行った。さらに15名の被験者の2歯をルートプレーニングし, 一方は週に1度, 1ヵ月間歯肉縁下洗浄を行い, 他方は行わなかった。その結果, ポケット洗浄液中の内毒素量とPD, GIおよびGBIは統計的に有意な正の相関を認めた。また, ルートプレーニング後に歯肉縁下洗浄を行った場合, 行わなかった場合に比較し, GI, GBIおよびポケット洗浄液中の内毒素量は低下し液中の内毒素量とPD, GIおよびGBIは統計的に有意な正の相関を認めた。また, ルートプレーニング後に歯肉縁下洗浄を行った場合, 行わなかった場合に比較し, GI, GBIおよびポケット洗浄液中の内毒素量は低下した。

歯間離開および歯の動揺と垂直性骨吸収の関連性についてX線写真を用いて研究を行った。本学歯周科来院患者の full-mouth X線写真から, 正しく撮影されたと判定した2,416枚を選択し, 診査表を参考に修復物や補綴物の装着された部位と歯の位置異常のある部位を除外し天然歯で隣接する部位, 計3,139隣接面を検索した。X線写真をトレースし, 歯間離開の距離, 垂直性骨吸収の程度を測定した。歯間離開の程度は class I (1mm>), class II (1mm≦

The purpose of this study was to evaluate the clinical effect of mace extract and egg-white lysozyme in two brands of chewing gum on gingival condition. Ever since mace extract containing dihydroguaiaretic acid was reported to inhibit the growth of Streptococcus mutans, plans were devised to include it in commercially available chewing gum. Before starting this study, two different types of experimental chewing gum containing mace extract or egg-white lysozyme were made up. A control was also prepared containing neither agent. The periodontal condition of 68 patients with gingivitis was determined based on PMA index (PMA), gingival index (GI), gingival bleeding index (GBI) and plaque scoring system (PSS) and randomly classified into three groups. Each group was instructed to use one or the other of the above type chewing gums after every meal. The results were as follows: 1. No clinical changes were observed in the control group during this study. 2. Gingival inflammation (PMA, GI, GBI) significantly improved as a result of using the experimental gums. 3. Plaque reduction was found only in the mece-extract gum group. 4. No clinical side effects were detected during this study.