Introduction. Endodontic iatrogenia, such as iatrogenic perforation, formation of ledges, blockage of canals, instrument breakage, unaddressed anatomical complexities, can have a substantial impact on the long-term outcome of endodontic treatment. The most frequent complications during endodontic treatments are root canal perforations, ledges, and instrument fractures. Prevention and management. Endodontic iatrogenia can be prevented by the use of AAE’s assessment tool (low, moderate, high difficulty cases), operator microscope, static/dynamic guided endodontics systems. Steps in management of endodontic iatrogenia consists of: assessment and diagnosis, communication with patient, immediate management, referral to specialist for non-surgical or surgical approach if necessary, monitorisation of healing process. Conclusions. Clinicians must possess a comprehensive understanding of the causes, prevention strategies, and reliable corrective measures for specific endodontic iatrogenia. Endodontic iatrogenia must be managed by individualised therapeutic approach using effective instrumentarium and biomaterials for positive long-term outcomes. Interdisciplinary collaboration of general dentist with specialists (endodontic specialist, oral surgeon) can be required in complex cases.