4 results on '"Chaves, Bárbara Aparecida"'
Search Results
2. Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil.
- Author
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Pinheiro TM, Mota MTO, Watanabe ASA, Biselli-Périco JM, Drumond BP, Ribeiro MR, Vedovello D, Araújo JP Jr, Pimenta PFP, Chaves BA, Silva MMCD, Batista ICA, Papa MP, Meuren LM, Lucas CGO, Matassoli FL, Gil LHVG, Bozzi A, Calzavara-Silva CE, Arruda LB, Souza DDG, Teixeira MM, Vasilakis N, and Nogueira ML
- Subjects
- Aedes physiology, Aedes virology, Animals, B-Lymphocytes immunology, Brazil, Cohort Studies, Dengue transmission, Dengue virology, Dengue Virus classification, Dengue Virus genetics, Dengue Virus isolation & purification, Genotype, Humans, Male, Mice, Inbred C57BL, Phylogeny, T-Lymphocytes immunology, Dengue immunology, Dengue Virus immunology
- Abstract
The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2018
- Full Text
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3. Dengue Infection Susceptibility of Five Aedes aegypti Populations from Manaus (Brazil) after Challenge with Virus Serotypes 1–4.
- Author
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Chaves, Bárbara Aparecida, Godoy, Raquel Soares Maia, Campolina, Thaís Bonifácio, Júnior, Ademir Bentes Vieira, Paz, Andréia da Costa, Vaz, Evelyn Beatriz da Costa, Silva, Breno Mello, Nascimento, Rêgila Mello, Guerra, Maria das Graças Vale Barbosa, Lacerda, Marcus Vinicius Guimarães, Monteiro, Wuelton Marcelo, Secundino, Nágila Francinete Costa, and Pimenta, Paulo Filemon Paolucci
- Subjects
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AEDES aegypti , *DENGUE viruses , *DENGUE , *SEROTYPES , *VIRAL load , *VIRAL variation , *VIRAL transmission , *ARBOVIRUS diseases - Abstract
The successful spread and maintenance of the dengue virus (DENV) in mosquito vectors depends on their viral infection susceptibility, and parameters related to vector competence are the most valuable for measuring the risk of viral transmission by mosquitoes. These parameters may vary according to the viral serotype in circulation and in accordance with the geographic origin of the mosquito population that is being assessed. In this study, we investigated the effect of DENV serotypes (1–4) with regards to the infection susceptibility of five Brazilian Ae. aegypti populations from Manaus, the capital of the state of Amazonas, Brazil. Mosquitoes were challenged by oral infection with the DENV serotypes and then tested for the presence of the arbovirus using quantitative PCR at 14 days post-infection, which is the time point that corresponds to the extrinsic incubation period of Ae. aegypti when reared at 28 °C. Thus, we were able to determine the infection patterns for DENV-1, -2, -3 and -4 in the mosquito populations. The mosquitoes had both interpopulation and inter-serotype variation in their viral susceptibilities. All DENV serotypes showed a similar tendency to accumulate in the body in a greater amount than in the head/salivary gland (head/SG), which does not occur with other flaviviruses. For DENV-1, DENV-3, and DENV-4, the body viral load varied among populations, but the head/SG viral loads were similar. Differently for DENV-2, both body and head/SG viral loads varied among populations. As the lack of phenotypic homogeneity represents one of the most important reasons for the long-term fight against dengue incidence, we expect that this study will help us to understand the dynamics of the infection patterns that are triggered by the distinct serotypes of DENV in mosquitoes. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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4. Simultaneous circulation of zakat, dengue, and chikungunya viruses and their vertical co-transmission among Aedes aegypti.
- Author
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Teixeira, Adriano Fernandes, de Brito, Breno Bittencourt, Correia, Thiago Macêdo Lopes, Viana, Airton Idalécio Sousa, Carvalho, Juliana Cabral, da Silva, Filipe Antônio França, Santos, Maria Luísa Cordeiro, da Silveira, Eliezer Almeida, Neto, Henry Paul Granger, da Silva, Natalia Maria Pereira, Rocha, Cínthya Viana Souza, Pinheiro, Fillipe Dantas, Chaves, Bárbara Aparecida, Monteiro, Wuelton Marcelo, de Lacerda, Marcus Vinícius Guimarães, Secundino, Nágila Francinete Costa, Pimenta, Paulo Filemon Paolucci, and de Melo, Fabrício Freire
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AEDES aegypti , *CHIKUNGUNYA virus , *ARBOVIRUS diseases , *ZAKAT , *DENGUE , *DENGUE viruses , *COMORBIDITY - Abstract
• Aedes aegypti larvae can be simultaneously infected by two arboviruses. • A vertical cotransmission of arboviruses to Ae. aegypti larvae may occur. • Ae. aegypti infestation indexes seem to be able to predict arboviral circulation. The outbreaks caused by the Aedes aegypti -transmitted dengue virus (DENV), zakat virus (ZIKV), and chikungunya virus (CHIKV) result in a significant impact to the health systems of tropical countries. Furthermore, the occurrence of patients coinfected by at least two of these arboviruses is an aggravating factor in that scenario. On this basis, surveillance tools such as the Rapid Index Survey for Aedes aegypti (LIRAa) are used to estimate vector infestation in order to improve the prediction of human outbreaks. Ae. aegypti eggs were collected in the city of Vitória da Conquista, in Bahia State, Brazil, and subsequently hatched into larvae, which were analyzed in pools or individually for the presence of DENV, ZIKV, and CHIKV by molecular biology methods. The detection data for arboviruses were crossed with the LIRAa obtained in each region of the study city. Thirty larvae pools were analyzed, and fourteen (46.6%) of them were detected positive for DENV, ZIKV, and/or CHIKV. Among the individually analyzed larvae (n = 30), nine (30%) were positive for any of these arboviruses, and four (13.3%) were simultaneously coinfected by DENV and ZIKV. Furthermore, there was a positive correlation between the detection of circulating arboviruses and LIRAa. The simultaneous Ae. aegypti larvae infection by two different arboviruses is an unprecedented finding. This result suggests the occurrence of a vertical arboviruses co-transmission from the female mosquito to its offspring in nature. The occurrence of concomitant circulation of DENV, ZIKV, and CHIKV in Ae. aegypti from a single study region is another finding of this article. Finally, LIRAa seems to not only estimate vector infestation but also to predict circulation of arboviruses. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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