Search

Abstract: Objective: To developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti leukemic activity of Prednisolone. Methods: For this study, PEGylated poly (propylene imine) dendritic architecture was synthesized and loaded with Prednisolone and targeted to the ascetic form of myelogenous leukemia k-562 cellines in hybrid mice BDF1, was used as tumor model. The antileukemic activity was assessed by use of the criterion T/C %, where T was the mean survival time (MST, days) of the drug treated mice, bearing k-562 leukemia and C – the mean survival time (MST, days) of untreated control animals, bearing the same leukemia cellines. Results: An antileukemic activity of the studied Prednisolone loaded PEGylated Polypropyleneimine (PPI) dendrimer was found to have increasing the mean survival time of the k-562 myelogenous leukemia cellines bearing BDF1 mice. The criterion “increase of life span” (ILS%) reached maximally 270.1% for the drug loaded dendrimer. Conclusion: The studied dendrimer with Prednisolone showed lower toxicity with improved antileukemic activity in comparison with free Prednisolone. The further experiments in this field are in progress, aiming to design better dendritic formulations, with potential clinical use [Copyright &y& Elsevier]

Abstract: Objective: To develop and explore the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti bacterial bioactive, Trimethoprim. Methods: For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with Trimethoprim and targeted to the resistant producing strains of both gram positive and gram negative. The antibacterial activity was carried out by agar well-diffusion method to compare zone of inhibition with standard drug and plain PPI dendrimer. Results: The study showed that the Trimethoprim loaded dendrimer has significant antibacterial activity than the plain PPI dendrimer, but standard drug was not shown zone of inhibition upon both microorganisms but Klebsiella pneumoniae (K. pneumoniae) the pure drug showed activity. Conclusions: In this study antibacterial activity of synthesized system is also relatively safer and holds potential to deliver any other antibacterial agent to the resistant producing strains. [Copyright &y& Elsevier]