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Background: In-vitro urease inhibitory and thermal induced protein denaturation inhibitory activities was performed for two commonly used herbal products Endemali and Akseer ULCER in the treatment of ulcers. Objectives: To evaluate the antiulcer potential of two commonly used herbal products, Endemali, Akseer ULCER. Material and Method: In urease inhibitory assay, enzyme solution, extract, diferent regaents added and absorbance was measured at 630 nm (50 min, pH 8.2) and thiourea used as standard. In protein denaturation assay, the egg albumin was mixed with different concentration of test compounds, buffer absorbance was measured. Aspirin was used as standard. Results: The Endemali had a profound effect on the urease activity in a concentration dependent manner with EC50 value of 0.468 mg/ml. The Akseer ULCER antagonized the urease activity markedly with EC50 value of 0.374 mg/ml. These tested herbal products caused marked inhibition of thermal induced protein denaturation in a concentration dependent manner. The potency in the form of EC50 for Endemali, Akseer ULCER was measured as 323, 337 μg/ml respectively. Conclusion: In short, the tested herbal drug showed strong inhibition on urease activity and inhibition on thermal induced protein denaturation thus our study validated their uses in the treatment of ulcers. [ABSTRACT FROM AUTHOR]