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On the base of clinical psychological and electrophysiological studies of 34 patients with primary manifestations of brain circulation insufficiency good tolerance and high efficiency of Tanakan course treatment (3 x 40 mg/day for 3 months) were showen. Tanakan decreased manifestations of clinical syndrome, improved psychological functions and electrophysiological parameters. Prospective study supported the stability of positive changes in the status of patients for 12 months after Tanakan course treatment.

Computed tomography was used to study the prevalence rates of various types of intracranial pathology, hydrocephalus (HDC) and cortical atrophy (CA) in patients with late dementia (LD) and to comparatively assess the informative value of tomographic methods of cerebral morphometry. Computed tomographic data were obtained from 432 patients with LD. Despite the type of dementia, the authors revealed intracranial abnormalities of various etiology in 24.5%, postischemic foci being prevalent. Tumors, arachnoidal cysts, and chronic subdural hematomas were more infrequently diagnosed (in 2.6% of cases). HDC and CA were detected in 81.5 and 82.2% of patients with LD, respectively.

Thirty-eight patients with late mentally deteriorating processes were studied. Using a standardized neuropsychological method, the authors have outlined four major variants of neuropsychological syndromes characteristic of damage to definite zones of the brain. Comparison of these data with the results of clinical and computer-aided tomographic examination showed that the neuropsychological approach is an adequate method in the combined study of senile dementia.