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Your search keyword '"Deryck, Olivier"' showing total 3 results
Start Over Author "Deryck, Olivier" Topic dementia
3 results on '"Deryck, Olivier"'

1. Dementia, End of Life, and Euthanasia: A Survey Among Dementia Specialists Organized by the Belgian Dementia Council.

Author

Picard G, Bier JC, Capron I, De Deyn PP, Deryck O, Engelborghs S, Hanseeuw B, Lemper JC, Mormont E, Petrovic M, Salmon E, Segers K, Sieben A, Thiery E, Ventura M, Versijpt J, and Ivanoiu A

Subjects
Advance Directives ethics, Advance Directives psychology, Attitude of Health Personnel, Belgium, Dementia psychology, Female, Humans, Male, Middle Aged, Societies, Medical, Surveys and Questionnaires, Terminal Care ethics, Dementia therapy, Euthanasia, Active, Voluntary ethics
Abstract

Background: Palliative care and Advance Care Planning (ACP) are increasingly recommended for an optimal management of late-stage dementia. In Belgium, euthanasia has been decriminalized in 2002 for patients who are "mentally competent" (interpreted as non-demented). It has been suggested that advance directives for euthanasia (ADE) should be made possible for dementia patients., Objective: This study presents the results of an internet survey among Belgian dementia specialists., Methods: In 2013, the Belgian Dementia Council (BeDeCo) organized a debate on end of life decisions in dementia. Participants were medical doctors who are specialists in the dementia field. After the debate, an anonymous internet survey was organized. The participation rate was 55%. The sample was representative of the BeDeCo members., Results: The results showed consensus in favor of palliative care and ACP, although ACP is not systematically addressed in practice. Few patients with dementia have requested euthanasia, but for those who did the participants had agreed to implement it for some patients. A majority of participants (94%) believe that most patients and their families are poorly informed about euthanasia. Although most participants (77%) said they approved the Law on euthanasia, 65% said they were against an extension of the Law to allow ADE for dementia., Conclusion: Palliative care and ACP are clearly accepted by professionals, although a gap between recommendation and practice remain. Euthanasia is a much more debated issue, even if a majority of professionals are, in principle, in favor of the current Law and seem to disapprove with a Law change allowing ADE for dementia. A better education for both health professionals and the lay public will be a key element in the future.

Published
2019
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2. Alzheimer’s disease and driving: review of the literature and consensus guideline from Belgian dementia experts and the Belgian road safety institute endorsed by the Belgian Medical Association

Author

Versijpt, Jan, Tant, Mark, Beyer, Ingo, Bier, Jean-Christophe, Cras, Patrick, De Deyn, Peter P., De Wit, Patrick, Deryck, Olivier, Hanseeuw, Bernard, Lambert, Margareta, Lemper, Jean-Claude, Mormont, Eric, Petrovic, Mirko, Picard, Gaetane, Salmon, Eric, Segers, Kurt, Sieben, Anne, Thiery, Evert, Tournoy, Jos, Vandewoude, Maurits, Ventura, Manfredi, Verschraegen, Jurn, Engelborghs, Sebastiaan, Goffin, Tom, Deneyer, Michel, and Ivanoiu, Adrian

Published
2017
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3. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability

Author

Cacace, Rita, Heeman, Bavo, Van Mossevelde, Sara, De Roeck, Arne, Hoogmartens, Julie, De Rijk, Peter, Gossye, Helena, De Vos, Kristof, De Coster, Wouter, Strazisar, Mojca, De Baets, Greet, Schymkowitz, Joost, Rousseau, Frederic, Geerts, Nathalie, De Pooter, Tim, Peeters, Karin, Sieben, Anne, Martin, Jean-Jacques, Engelborghs, Sebastiaan, Salmon, Eric, Santens, Patrick, Vandenberghe, Rik, Cras, Patrick, De Deyn, Peter P, van Swieten, John C, van Duijn, Cornelia M, van der Zee, Julie, Sleegers, Kristel, Van Broeckhoven, Christine, BELNEU Consortium, on behalf of the, Goeman, Johan, Crols, Roeland, Nuytten, Dirk, De Bleecker, Jan, Van Langenhove, Tim, Ivanoiu, Adrian, Deryck, Olivier, Bergmans, Bruno, Versijpt, Jan, Michotte, Alex, Delbeck, Jean, Willems, Christiana, De Klippel, Nina, Neurology, Epidemiology, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Faculty of Sciences and Bioengineering Sciences, Department of Bio-engineering Sciences, Clinical sciences, Physiotherapy, Human Physiology and Anatomy, and Pathologic Biochemistry and Physiology

Subjects
0301 basic medicine, Male, NATIONAL INSTITUTE, Potassium Channels, Action Potentials, Penetrance, neurodegenerative brain diseases, Synaptic Transmission, 0302 clinical medicine, C9orf72, Pathology, Medicine and Health Sciences, Homeostasis, BEHAVIORAL VARIANT, MUTATION, Genes, Dominant, Neurons, Medicine(all), Protein Stability, Neurodegeneration, Neurodegenerative Diseases, Frontotemporal lobar degeneration, ASSOCIATION, Middle Aged, Pedigree, ALZHEIMERS-DISEASE, PROTEIN DPPX, Protein Transport, Female, Life Sciences & Biomedicine, Chromosomes, Human, Pair 7, Frontotemporal dementia, Adult, Clinical Neurology, C9ORF72, Nerve Tissue Proteins, DPP6, Hyperexcitability, Biology, Polymorphism, Single Nucleotide, Pathology and Forensic Medicine, Frameshift mutation, Oxford nanopore technologies (ONT) PromethION, 03 medical and health sciences, Cellular and Molecular Neuroscience, medicine, Dementia, Humans, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Loss function, Aged, Original Paper, FRONTOTEMPORAL LOBAR DEGENERATION, Science & Technology, Neurodegenerative brain diseases, Neurosciences, Biology and Life Sciences, medicine.disease, STRUCTURAL VARIATION, 030104 developmental biology, Whole genome sequencing, Chromosome Inversion, Mutation, Neurology (clinical), Neurosciences & Neurology, Human medicine, Neuroscience, 030217 neurology & neurosurgery, DENDRITIC EXCITABILITY, dementia
Abstract

Emerging evidence suggested a converging mechanism in neurodegenerative brain diseases (NBD) involving early neuronal network dysfunctions and alterations in the homeostasis of neuronal firing as culprits of neurodegeneration. In this study, we used paired-end short-read and direct long-read whole genome sequencing to investigate an unresolved autosomal dominant dementia family significantly linked to 7q36. We identified and validated a chromosomal inversion of ca. 4 Mb, segregating on the disease haplotype and disrupting the coding sequence of dipeptidyl-peptidase 6 gene (DPP6). DPP6 resequencing identified significantly more rare variants—nonsense, frameshift, and missense—in early-onset Alzheimer’s disease (EOAD, p value = 0.03, OR = 2.21 95% CI 1.05–4.82) and frontotemporal dementia (FTD, p = 0.006, OR = 2.59, 95% CI 1.28–5.49) patient cohorts. DPP6 is a type II transmembrane protein with a highly structured extracellular domain and is mainly expressed in brain, where it binds to the potassium channel Kv4.2 enhancing its expression, regulating its gating properties and controlling the dendritic excitability of hippocampal neurons. Using in vitro modeling, we showed that the missense variants found in patients destabilize DPP6 and reduce its membrane expression (p

Published
2019

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