1. Association between amphetamine-related disorders and dementia-a nationwide cohort study in Taiwan.
- Author
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Tzeng NS, Chien WC, Chung CH, Chang HA, Kao YC, and Liu YP
- Subjects
- Adult, Aged, Alzheimer Disease epidemiology, Amphetamine-Related Disorders complications, Databases, Factual, Dementia etiology, Female, Humans, Male, Middle Aged, Psychoses, Substance-Induced etiology, Retrospective Studies, Taiwan epidemiology, Young Adult, Amphetamine-Related Disorders epidemiology, Dementia epidemiology, Psychoses, Substance-Induced epidemiology
- Abstract
Objective: We have conducted a study to clarify the association between amphetamine-related disorders (ARD) and the risk of developing dementia., Methods: This study used a retrospective cohort design by using Taiwan's National Health Research Institute Database. A random sample of 68,300 subjects between January 1, 2000, and December 31, 2015, was obtained, comprising of 17,075 patients with ARD, and 51,225 controls without ARD (1:3), matched for gender and age group. After adjusting for covariates, a Fine and Gray's survival analysis (competing with mortality) was used to compare the risk of dementia during a 15-year follow-up period., Results: In the present study, 1,751 of 17,075 patients with ARD and 2,147 of 51,225 in the control group without ARD (883.10 vs 342.83 per 100,000 person-years) developed dementia. ARD cohort was more likely to develop dementia (hazard ratio = 4.936 [95% CI: 4.609-5.285, P < 0.001). After adjusting for gender, age groups, education, monthly insured premiums, urbanization level, geographic region, comorbidities, the hazard ratio for ARD patients was 5.034 (95% CI: 4.701-5.391, P < 0.001). ARD has been associated with overall dementia, Alzheimer dementia, vascular dementia, and other dementia. Both the amphetamine use disorder and amphetamine-induced psychotic disorders were associated with the risk of overall dementia, Alzheimer dementia, vascular dementia, and other dementia., Interpretation: This study shows that patients with ARD, both the amphetamine use disorder and the amphetamine-induced psychotic disorder, may have a nearly fivefold risk of developing dementia, including Alzheimer dementia and other types of dementia., (© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
- Published
- 2020
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