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Start Over Author "Zeng, Jun‐Liang" Topic dehydrogenation
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1. Copper-Catalyzed One-Pot Denitrogenative-Dehydrogenative-Decarboxylative Coupling of β-Ketoacids with Trifluorodiazoethane: Facile Access to Trifluoromethylated Aldol Products.

Author

Xiong, Heng‐Ying, Yang, Zhen‐Yan, Chen, Zhen, Zeng, Jun‐Liang, Nie, Jing, and Ma, Jun‐An

Subjects
DEHYDROGENATION, DECARBOXYLATION, KETONIC acids, TRIFLUOROMETHYL compounds, ENANTIOSELECTIVE catalysis
Abstract

A novel copper-catalyzed one-pot cross-coupling of β-ketoacids with in situ generated trifluorodiazoethane has been developed. This reaction provides a direct and efficient method, in which one CC bond and one CO bond were formed in a carbenoid center with concomitant denitrogenation-dehydrogenation-decarboxylation, to afford trifluoromethylated aldol products. In several preliminary experiments, good to high enantioselectivities were also obtained. [ABSTRACT FROM AUTHOR]

Published
2014
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