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Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. In a prospective, self-controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. Between 1995 and 1998 15 patients with gastric pull up, 10 patients with colon replacement or bypass and eight patients with free jejunum transplant or jejunum replacement were evaluated. Esophageal transit scintigraphy was performed before and after cisapride administration. From the time–activity curves, the half-life of radiolabeled bolus in the esophagus was calculated and preadministration and postadministration half-lives were compared. Cisapride significantly reduced the half-life of radiolabeled bolus in the substitute in the case of stomach and jejunum replacement, while for colon replacement the results were dispersed too widely to yield significant difference. Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection. [ABSTRACT FROM AUTHOR]