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Your search keyword '"Manzetti, Marco"' showing total 3 results
Start Over Author "Manzetti, Marco" Topic degenerative disc disease
3 results on '"Manzetti, Marco"'

2. Complications after Posterior Lumbar Fusion for Degenerative Disc Disease: Sarcopenia and Osteopenia as Independent Risk Factors for Infection and Proximal Junctional Disease.

Author

Ruffilli, Alberto, Manzetti, Marco, Barile, Francesca, Ialuna, Marco, Cerasoli, Tosca, Viroli, Giovanni, Salamanna, Francesca, Contartese, Deyanira, Giavaresi, Gianluca, and Faldini, Cesare

Subjects
*SARCOPENIA, *DEGENERATION (Pathology), *OSTEOPENIA, *SURGICAL site infections, *SPINAL surgery, *LUMBAR vertebrae
Abstract

Proximal Junctional Disease (PJD) and Surgical Site Infection (SSI) are among the most common complications following spine surgery. Their risk factors are not fully understood. Among them, sarcopenia and osteopenia have recently been attracting interest. The aim of this study is to evaluate their influence on mechanical or infective complications after lumbar spine fusion. Patients who underwent open posterior lumbar fusion were analyzed. Through preoperative MRI, central sarcopenia and osteopenia were measured with the Psoas Lumbar Vertebral Index (PLVI) and the M-Score, respectively. Patients were stratified by low vs. high PLVI and M-Score and then by postoperative complications. Multivariate analysis for independent risk factors was performed. A total of 392 patients (mean age 62.6 years, mean follow up 42.4 months) were included. Multivariate linear regression identified comorbidity Index (p = 0.006), and dural tear (p = 0.016) as independent risk factors for SSI, and age (p = 0.014) and diabetes (p = 0.43) for PJD. Low M-score and PLVI were not correlated to a higher complications rate. Age, comorbidity index, diabetes, dural tear and length of stay are independent risk factors for infection and/or proximal junctional disease in patients who undergo lumbar arthrodesis for degenerative disc disease, while central sarcopenia and osteopenia (as measured by PLVI and M-score) are not. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Mechanobiology of the Human Intervertebral Disc: Systematic Review of the Literature and Future Perspectives.

Author

Ruffilli, Alberto, Viroli, Giovanni, Neri, Simona, Traversari, Matteo, Barile, Francesca, Manzetti, Marco, Assirelli, Elisa, Ialuna, Marco, Vita, Fabio, and Faldini, Cesare

Subjects
LUMBAR pain, TECHNOLOGICAL innovations, HUMAN biology, HUMAN mechanics, SYNTHETIC biology
Abstract

Low back pain is an extremely common condition with severe consequences. Among its potential specific causes, degenerative disc disease (DDD) is one of the most frequently observed. Mechanobiology is an emerging science studying the interplay between mechanical stimuli and the biological behavior of cells and tissues. The aim of the presented study is to review, with a systematic approach, the existing literature regarding the mechanobiology of the human intervertebral disc (IVD), define the main pathways involved in DDD and identify novel potential therapeutic targets. The review was carried out in accordance with the Preferential Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Studies were included if they described biological responses of human IVD cells under mechanical stimulation or alterations of mechanical properties of the IVD determined by different gene expression. Fifteen studies were included and showed promising results confirming the mechanobiology of the human IVD as a key element in DDD. The technical advances of the last decade have allowed us to increase our understanding of this topic, enabling us to identify possible therapeutic targets to treat and to prevent DDD. Further research and technological innovations will shed light on the interactions between the mechanics and biology of the human IVD. [ABSTRACT FROM AUTHOR]

Published
2023
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