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Background. Today, vitamin D deficiency and insufficiency is a global problem of public health affecting an estimated 1 billion people worldwide. Numerous studies show that the biological effects of vitamin D are not limited to the regulation of calcium-phosphorus metabolism; it also affects other physiological processes in the body. The purpose of the study was to evaluate the efficacy and safety of dietary supplement Olidetrim in the correction of vitamin D deficiency in postmenopausal women, and to study the effects of vitamin D levels on pain severity and quality of life. Materials and me­thods. The study included 26 postmenopausal women aged 50 to 83 years who had a deficiency or insufficiency of vitamin D. All patients took Olidetrim 1000 IU, 1 capsule 3 times a day for 3 months. At each visit, we examined the level of 25(OH)D using electrochemiluminescent method, severity of low back pain by means of a visual analogue scale, the algo-functional state of large joints was determined using the WOMAC scale (subscales of pain, stiffness, physical functioning), the patient’s quality of life was evaluated on the ECOS-16 scale. Assessment of the condition was carried out after 1 and 3 months. Results. Level of 25(OH)D significantly increased in the examined women after 1 (p = 0.000004) and 3 months (p = 0.000002) of Olidetrim intake. After 3 months of taking Olidetrim, vitamin D deficiency in postmenopausal women was not registered, 69.6 % of patients had vitamin D insufficiency, and the level of vitamin D was optimal in 30.4 % of patients. The maximum level of pain significantly decreased after 1 (p = 0.01) and 3 months (p = 0.01). According to the results of the WOMAC questionnaire, we found a significant increase of daily activity after 1 and 3 months in patients who received Olidetrim. During the observation period, women had no side effects associated with taking a dietary supplement. Conclusions. Olidetrim is an effective and safe dietary supplement for the correction of vitamin D deficiency in postmenopausal women.

Background. Vitamin D deficiency is prevalent in all the world countries. Recent studies show the correlation between vitamin D deficiency and musculoskeletal disorders. The purpose of this study is to examine vitamin D deficiency and insufficiency prevalence in patients of various ages, who have musculoskeletal disorders, and to reveal the influence of seasonal factors on these conditions. Materials and methods. 3460 patients of the Ukrainian Scientific Medical Center of Osteoporosis Problems, aged 1 to 92 years, who were referred by other specialists to the center for bone state evaluation, were examined. A majority of the patients presented with osteoporosis and its complications, spinal osteochondrosis, knee and hip osteoarthritis (mean age — 52.90 ± 21.10 years). Most of the patients were women (83.5 %). 25(ОН)D and parathyroid hormone analyses were performed by means of electrochemiluminescent method (Elecsys 2010 analyzer, Roche Diagnostics, Germany) and cobas test-systems. Statistica 6.0 software package (Copyright StatSoft, Inc., 1984–2001) was also used. Results. Among the patients with musculoskeletal pathology, the highest 25(ОН)D level was noted in the age group of 1–9 years and the lowest — in the age group of 80 and over. Age negatively influenced 25(ОН)D values. Prevalence of vitamin D deficiency among the patients with musculoskeletal pathology was 37.3 %, vitamin D insufficiency — 30.6 %; 32.1 % of patients had normal vitamin D status. Normal 25(OH)D level was found in 38.0 % of children, 33.2 % of adults and in 29.6 % of elderly patients. Month of blood sampling had a significant influence on 25(ОН)D content (F = 7.49; p