1. Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR)
- Author
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Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., Torre, M., Macini, S., Perinotti, R., Serventi, A., Fiorino, M., Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., Torre, M., Macini, S., Perinotti, R., Serventi, A., and Fiorino, M.
- Subjects
Male ,medicine.medical_treatment ,haemorrhoidal disease ,post-operative pain ,open excisional haemorrhoidectomy ,mesoglycan ,thrombosis ,mucocutaneous bridges ,Open excisional haemorrhoidectomy ,Haemorrhoidal disease ,Mesoglycan ,Mucocutaneous bridges ,Post-operative pain ,Thrombosis ,Mucocutaneous bridge ,Retrospective Studie ,80 and over ,Glycosaminoglycans ,Aged, 80 and over ,Pain, Postoperative ,Fibrinolytic Agent ,General Medicine ,Middle Aged ,Colorectal surgery ,Treatment Outcome ,Thrombosi ,Female ,Human ,Research Article ,Adult ,Hemorrhoidectomy ,medicine.medical_specialty ,lcsh:Surgery ,Pain ,Hemorrhoids ,Young Adult ,Pain control ,Fibrinolytic Agents ,medicine ,Humans ,Postoperative ,Aged ,Retrospective Studies ,business.industry ,Gold standard ,Correction ,Diathermy ,lcsh:RD1-811 ,medicine.disease ,Surgery ,Glycosaminoglycan ,Defecation ,Observational study ,business ,Hemorrhoid - Abstract
Background Excisional haemorrhoidectomy is the gold standard technique in patients with III and IV degree haemorrhoidal disease (HD). However, it is associated with a significant rate of post-operative pain. The aim of our study was to evaluate the efficacy of mesoglycan in the post-operative period of patients who underwent open excisional diathermy haemorrhoidectomy (OEH). Methods This was a retrospective multicentre observational study. Three hundred ninety-eight patients from sixteen colorectal referral centres who underwent OEH for III and IV HD were enrolled. All patients were followed-up on the first post-operative day (T1) and after 1 week (T2), 3 weeks (T3) and 6 weeks (T4). BMI, habits, SF-12 questionnaire, VAS at rest (VASs), after defecation (VASd), and after anorectal digital examination (VASe), bleeding and thrombosis, time to surgical wound healing and autonomy were evaluated. Results In the mesoglycan group, post-operative thrombosis was significantly reduced at T2 (p Conclusions The use of mesoglycan led to a significant reduction in post-operative thrombosis and pain with consequent early resumption of autonomy. Trial registration NCT04481698—Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy (MeHAEMO) https://clinicaltrials.gov/ct2/show/NCT04481698?term=Mesoglycan+for+Pain+Control+After+Open+Excisional+HAEMOrrhoidectomy+%28MeHAEMO%29&draw=2&rank=1
- Published
- 2020