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Motivation: To characterize long non-coding RNAs (lncRNAs), both identifying and functionally annotating them are essential to be addressed. Moreover, a comprehensive construction for lncRNA annotation is desired to facilitate the research in the field., Results: We present LncADeep, a novel lncRNA identification and functional annotation tool. For lncRNA identification, LncADeep integrates intrinsic and homology features into a deep belief network and constructs models targeting both full- and partial-length transcripts. For functional annotation, LncADeep predicts a lncRNA's interacting proteins based on deep neural networks, using both sequence and structure information. Furthermore, LncADeep integrates KEGG and Reactome pathway enrichment analysis and functional module detection with the predicted interacting proteins, and provides the enriched pathways and functional modules as functional annotations for lncRNAs. Test results show that LncADeep outperforms state-of-the-art tools, both for lncRNA identification and lncRNA-protein interaction prediction, and then presents a functional interpretation. We expect that LncADeep can contribute to identifying and annotating novel lncRNAs., Availability and Implementation: LncADeep is freely available for academic use at http://cqb.pku.edu.cn/ZhuLab/lncadeep/ and https://github.com/cyang235/LncADeep/., Supplementary Information: Supplementary data are available at Bioinformatics online.

The widespread adoption of social media platforms has led to an influx of data that reflects public sentiment, presenting a novel opportunity for market analysis. This research aims to quantify the correlation between the fleeting sentiments expressed on social media and the measurable fluctuations in the stock market. By adapting a pre-existing sentiment analysis algorithm, we refined a model specifically for evaluating the sentiment of tweets associated with financial markets. The model was trained and validated against a comprehensive dataset of stock-related discussions on Twitter, allowing for the identification of subtle emotional cues that may predict changes in stock prices. Our quantitative approach and methodical testing have revealed a statistically significant relationship between sentiment expressed on Twitter and subsequent stock market activity. These findings suggest that machine learning algorithms can be instrumental in enhancing the analytical capabilities of financial experts. This article details the technical methodologies used, the obstacles overcome, and the potential benefits of integrating machine learning-based sentiment analysis into the realm of economic forecasting. [ABSTRACT FROM AUTHOR]