1. Protective Effect of Hydrogen-Rich Saline on Decompression Sickness in Rats
- Author
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Runping Li, Zhimin Kang, Rongjia Zhang, Xiao-Xiao Ni, Kan Liu, Zhiyu Cai, Dan-Feng Fan, Yun Liu, Weigang Xu, Shulin Liu, and Xuejun Sun
- Subjects
Male ,medicine.medical_specialty ,Antioxidant ,medicine.medical_treatment ,Sodium Chloride ,medicine.disease_cause ,Rats, Sprague-Dawley ,Decompression sickness ,Random Allocation ,chemistry.chemical_compound ,Malondialdehyde ,Internal medicine ,medicine ,Animals ,Lung ,Saline ,Peroxidase ,Cerebral Cortex ,Analysis of Variance ,Hydrogen rich saline ,Chi-Square Distribution ,medicine.diagnostic_test ,business.industry ,Public Health, Environmental and Occupational Health ,Deoxyguanosine ,Decompression Sickness ,medicine.disease ,Rats ,Oxidative Stress ,Endocrinology ,Bronchoalveolar lavage ,Spinal Cord ,chemistry ,8-Hydroxy-2'-Deoxyguanosine ,Immunology ,Histopathology ,business ,Bronchoalveolar Lavage Fluid ,Injections, Intraperitoneal ,Oxidative stress ,Hydrogen - Abstract
INTRODUCTION Hydrogen (H2) has been reported to be effective in the treatment of oxidative injury, which plays an important role in the process of decompression sickness (DCS). This study was designed to test whether H2-rich saline (saline saturated with molecular hydrogen) protected rats against DCS. METHODS Models of DCS were induced in male Sprague-Dawley rats weighing 300-310 g. H2-rich (0.86 mmol x L(-1)) saline was administered intraperitoneally (10 ml x kg(-1)) at 24 h, 12 h, immediately before compression, and right after fast decompression. RESULTS H2-rich saline significantly decreased the incidence of DCS from 67.57 to 35.14% and partially counteracted the increases in the total concentration of protein in the bronchoalveolar lavage from 0.33 +/- 0.05 to 0.14 +/- 0.01 mg x ml(-1) (mean +/- SD; P < 0.05), myeloperoxidase activity from 0.86 +/- 0.16 to 0.44 +/- 0.13 U/g, levels of malondialdehyde (MDA) from 0.80 +/- 0.10 to 0.48 +/- 0.05 nmol x mg(-1), 8-hydroxydeoxyguanosine from 253.7 +/- 9.3 to 191.2 +/- 4.8 pg x mg(-1) in the lungs, and MDA level from 1.77 +/- 0.20 to 0.87 +/- 0.23 nmol x mg(-1) in the spinal cord in rat DCS models. The histopathology results also showed that H2-rich saline ameliorated DCS injuries. DISCUSSION It is concluded that H2-rich saline may have a protective effect against DCS, possibly due to its antioxidant action.
- Published
- 2011