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De Quervain's tenosynovitis (DQT) is degeneration and thickening of tendon sheath of 1st dorsal compartment of the wrist that contains abductor pollicis longus and extensor pollicis brevis tendon. In this case, we have chosen fenestration technique along with hydrodissection of tendon sheath for minimal interventional management. Fenestration technique involves gently passing a needle through the tendon sheath multiple times to and fro movement to change a chronic degenerative process into an acute condition that is more likely to heal. This procedure is done to see the effect of fenestration technique along with hydrodissection in view of pain relief and functional improvement. A 47-year-old female patient with DQT managed with ultrasonography guided fenestration followed by hydrodissection using 5% dextrose. Follow-up was taken after 1 month of procedure. The patient has 70%-80% pain relief quantified with numerical rating scale and 80% functional improvement. [ABSTRACT FROM AUTHOR]