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Your search keyword '"Hapfelmeier, Alexander"' showing total 29 results
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29 results on '"Hapfelmeier, Alexander"'

1. Elevated microsatellite instability at selected tetranucleotide (EMAST) repeats in gastric cancer: a distinct microsatellite instability type with potential clinical impact?

Author

Herz, Anna2̆010Lina, Wisser, Sarah, Kohlruss, Meike, Slotta\0̆10Huspenina, Julia, Jesinghaus, Moritz, Grosser, Bianca, Steiger, Katja, Novotny, Alexander, Hapfelmeier, Alexander, Schmidt, Thomas, Gaida, Matthias M, Weichert, Wilko, and Keller, Gisela

Subjects
Original Article, Original Articles, EMAST, microsatellite instability, gastric adenocarcinoma, neoadjuvant chemotherapy, prognosis, ddc
Published
2021

2. Relation Between Gender and Concomitant Medications With Erythropoietin-Treatment on Wound Healing in Burn Patients. Post Hoc Subgroup-Analysis of the Randomized, Placebo-Controlled Clinical Trial

Author

Günter, Christina Irene, Ilg, Felicitas Paula, Hapfelmeier, Alexander, Egert-Schwender, Silvia, Jelkmann, Wolfgang, Giri, Shibashish, Bader, Augustinus, and Machens, Hans-Günter

Subjects
Pharmacology, erythropoietin (EPO), burn injuries, gender, regenerative medicine, wound healing, randomized clinical trial, ddc
Published
2021

7. Prediction of lung emphysema in COPD by spirometry and clinical symptoms: results from COSYCONET

Author

Kellerer, Christina, Jörres, Rudolf A., Schneider, Antonius, Alter, Peter, Kauczor, Hans-Ulrich, Jobst, Bertram, Biederer, Jürgen, Bals, Robert, Watz, Henrik, Behr, Jürgen, Kauffmann-Guerrero, Diego, Lutter, Johanna, Hapfelmeier, Alexander, Magnussen, Helgo, Trudzinski, Franziska C., Welte, Tobias, Vogelmeier, Claus F., and Kahnert, Kathrin

Subjects
Research, Emphysema, CT scan, Decision trees, Random forest, Adaboost, COPD phenotypes, ddc
Published
2020

8. Antimicrobial peptides in human synovial membrane as (low-grade) periprosthetic joint infection biomarkers

Author

Banke, Ingo J., Stade, Niko, Prodinger, Peter M., Tübel, Jutta, Hapfelmeier, Alexander, von Eisenhart-Rothe, Rüdiger, van Griensven, Martijn, Gollwitzer, Hans, and Burgkart, Rainer

Subjects
Research, Joint replacement, Arthroplasty, Periprosthetic infection, Biomarker, Synovial membrane, Histological diagnosis, Antimicrobial peptide (AMP), Human beta-defensin (HBD), Cathelicidin (LL-37), ddc
Published
2019

11. Prognostic implication of molecular subtypes and response to neoadjuvant chemotherapy in 760 gastric carcinomas: role of Epstein–Barr virus infection and high‐ and low‐microsatellite instability

Author

Kohlruss, Meike, Grosser, Bianca, Krenauer, Marie, Slotta‐Huspenina, Julia, Jesinghaus, Moritz, Blank, Susanne, Novotny, Alexander, Reiche, Magdalena, Schmidt, Thomas, Ismani, Liridona, Hapfelmeier, Alexander, Mathias, Daniel, Meyer, Petra, Gaida, Matthias M, Bauer, Lukas, Ott, Katja, Weichert, Wilko, and Keller, Gisela

Subjects
ddc
Published
2018

15. Polyscore of Non-invasive Cardiac Risk Factors

Author

Steger, Alexander, Müller, Alexander, Barthel, Petra, Dommasch, Michael, Huster, Katharina Maria, Hnatkova, Katerina, Sinnecker, Daniel, Hapfelmeier, Alexander, Malik, Marek, and Schmidt, Georg

Subjects
ddc
Published
2018

29. Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study

Author

Alexander Hapfelmeier, Axel Walch, Alexander Novotny, Karen Becker, Katja Ott, Lukas Bauer, Rupert Langer, Julia Slotta-Huspenina, Agnes Takacs, and Gisela Keller

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Pathology, endocrine system, receptor NOTCH2, medicine.medical_treatment, receptor NOTCH1, Notch signaling pathway, 610 Medicine & health, chemotherapy, lcsh:RC254-282, Text mining, Internal medicine, Tumor stage, Medicine, Clinical significance, Original Research, Chemotherapy, Tissue microarray, stomach neoplasms, business.industry, Cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, ddc, embryonic structures, immunohistochemistry, 570 Life sciences, biology, Immunohistochemistry, Prognosis, Receptor Notch1, Receptor Notch2, Stomach Neoplasms, sense organs, prognosis, business
Abstract

BACKGROUND NOTCH signaling can exert oncogenic or tumor suppressive functions and can contribute to chemotherapy resistance in cancer. In this study, we aimed to clarify the clinicopathological significance and the prognostic and predictive value of NOTCH1 and NOTCH2 expression in gastric cancer (GC). METHODS NOTCH1 and NOTCH2 expression was determined immunohistochemically in 142 primarily resected GCs using tissue microarrays and in 84 pretherapeutic biopsies from patients treated by neoadjuvant chemotherapy. The results were correlated with survival, response to therapy, and clinico-pathological features. RESULTS Primarily resected patients with NOTCH1-negative tumors demonstrated worse survival. High NOTCH1 expression was associated with early-stage tumors and with significantly increased survival in this subgroup. Higher NOTCH2 expression was associated with early-stage and intestinal-type tumors and with better survival in the subgroup of intestinal-type tumors. In pretherapeutic biopsies, higher NOTCH1 and NOTCH2 expression was more frequent in non-responding patients, but these differences were statistically not significant. CONCLUSION Our findings suggested that, in particular, NOTCH1 expression indicated good prognosis in GC. The close relationship of high NOTCH1 and NOTCH2 expression with early tumor stages may indicate a tumor-suppressive role of NOTCH signaling in GC. The role of NOTCH1 and NOTCH2 in neoadjuvantly treated GC is limited.

Published
2015
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