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1. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS

Author: Hellbach, F., Sinke, L., Costeira, R., Baumeister, S.E., Beekman, M., Louca, P., Leeming, E.R., Mompeo, O., Berry, S., Wilson, R., Wawro, N., Freuer, D., Hauner, H., Peters, A., Winkelmann, J., Koenig, W., Meisinger, C., Waldenberger, M., Heijmans, B.T., Slagboom, P.E., Bell, J.T., and Linseisen, J.
Subjects: Nutrition and Dietetics, Medicine (miscellaneous), Humans, Diet, Ewas, Food Group, High-fat Foods, ddc:610, Food group, High-fat foods, EWAS
Abstract: Purpose Examining epigenetic patterns is a crucial step in identifying molecular changes of disease pathophysiology, with DNA methylation as the most accessible epigenetic measure. Diet is suggested to affect metabolism and health via epigenetic modifications. Thus, our aim was to explore the association between food consumption and DNA methylation. Methods Epigenome-wide association studies were conducted in three cohorts: KORA FF4, TwinsUK, and Leiden Longevity Study, and 37 dietary exposures were evaluated. Food group definition was harmonized across the three cohorts. DNA methylation was measured using Infinium MethylationEPIC BeadChip in KORA and Infinium HumanMethylation450 BeadChip in the Leiden study and the TwinsUK study. Overall, data from 2293 middle-aged men and women were included. A fixed-effects meta-analysis pooled study-specific estimates. The significance threshold was set at 0.05 for false-discovery rate-adjusted p values per food group. Results We identified significant associations between the methylation level of CpG sites and the consumption of onions and garlic (2), nuts and seeds (18), milk (1), cream (11), plant oils (4), butter (13), and alcoholic beverages (27). The signals targeted genes of metabolic health relevance, for example, GLI1, RPTOR, and DIO1, among others. Conclusion This EWAS is unique with its focus on food groups that are part of a Western diet. Significant findings were mostly related to food groups with a high-fat content.
Published: 2022

2. Plasma carotenoids as biomarkers of intake of fruits and vegetables

Author: Wl, Al-Delaimy, Ferrari, P., Slimani, N., Pala, V., Johannson, I., Nilsson, S., Mattisson, I., Wirfalt, E., Galasso, R., Palli, D., Veneis, P., Tumino, R., Dorronsoro, M., Pera, G., Mc, Ocke, Hb, Bueno-De-Mesquita, Kim Overvad, Chirlaque, M., Trichopoulou, A., Naska, A., Tjønneland, A., Anja Viendahl Olsen, Lund, E., Eh, Alsaker, Barricate, A., Kesse, E., Mc, Boutron-Ruault, Clavel-Chapelon, F., Tj, Key, Spencer, E., Bingham, S., Aa, Welch, Mj Sanchez-Perez, Nagel, G., Linseisen, J., Jr, Quiros, Ph, Peeters, Ch, Gils, Boeing, H., Al, Kappel, Jp, Steghens, Riboli, E., and University of Groningen
Subjects: Male, COUNTRIES, BLOOD, Alcohol Drinking, SERUM CAROTENOIDS, EPIDEMIOLOGIC EVIDENCE, Medicine (miscellaneous), fruits and vegetables, Xanthophylls, Antioxidants, VALIDATION, Body Mass Index, Cohort Studies, Zeaxanthins, 24-HOUR DIET RECALL, Surveys and Questionnaires, Vegetables, Humans, ddc:610, Prospective Studies, Life Style, Cryptoxanthins, plasma, CALIBRATION, Nutrition and Dietetics, STABILITY, Lutein, Smoking, carotenoids, food and beverages, CONSUMPTION, Middle Aged, beta Carotene, FOOD FREQUENCY QUESTIONNAIRES, Cross-Sectional Studies, Fruit, Mental Recall, Female, Seasons, EPIC, Biomarkers, 24 h dietary recall
Abstract: Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods.Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included.Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%).Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.
Published: 2005

3. Enterolactone concentrations and prognosis after postmenopausal breast cancer: Assessment of effect modification and meta-analysis

Author: Seibold, P., Vrieling, A., Johnson, T.S., Buck, K., Behrens, S., Kaaks, R., Linseisen, J., Obi, N., Heinz, J., Flesch-Janys, D., and Chang-Claude, J.
Subjects: Breast Neoplasms, Middle Aged, breast cancer mortality, enterolactone, lignans, phytoestrogens, Prognosis, Disease-Free Survival, Lignans, Body Mass Index, Diet, Postmenopause, 4-Butyrolactone, Risk Factors, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Germany, Biomarkers, Tumor, Disease Progression, Humans, Female, Prospective Studies, ddc:610, Life Style, Aged, Proportional Hazards Models
Abstract: Item does not contain fulltext We previously reported that high concentrations of enterolactone, a lignan metabolite, are associated with lower mortality in 1,140 breast cancer patients from Germany. Using an extended set of 2,182 patients aged 50-74 years at diagnosis (2001-2005) and prospectively followed up until 2009, we investigated whether the association with mortality differs by lifestyle factors and tumor characteristics. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression. Potential differential effects by tumor characteristics and lifestyle factors were assessed and a meta-analysis of five studies addressing lignan exposure and breast cancer prognosis was performed to summarize evidence. Median enterolactone concentrations were 17.4 (+/-30.5 standard deviation) and 22.9 nmol L(-1) (+/-44.8), respectively, for 269 deceased and 1,913 patients still alive. High enterolactone concentrations were significantly associated with lower all-cause mortality (per 10 nmol L(-1) : HR 0.94, 95% CI 0.90-0.98), breast cancer-specific mortality (HR 0.94, 0.89-0.99), and distant disease-free survival (HR 0.94, 0.90-0.98). Associations were found for stage 0-IIIA but not for stage IIIB-IV disease (phet = 0.01) and were stronger in patients with BMI /=25 (phet = 0.04). In patients with healthy lifestyle (BMI
Published: 2014

4. Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation into Cancer and Nutrition

Author: Miller, A.B., Altenburg, H.P., Bueno-de-Mesquita, B., Boshuizen, H.C., Agudo, A., Berrino, F., Gram, I.T., Janson, L., Linseisen, J., Overvad, Kim, Rasmuson, T., Vineis, P., Lukanova, A., Allen, N., Amiano, P., Barricarte, A., Berglund, G., Boeing, H., Clavel-Chapelon, F., Day, N.E., Hallmans, G., Lund, E., Martinez, C., Navarro, C., Palli, D., Panico, S., Peeters, P.H., Quiros, J.R., Tjønneland, A., Tumino, R., Trichopoulou, A., Trichopoulos, D., Slimani, N., Riboli, E., Miller, Ab, Altenburg, Hp, BUENO DE MESQUITA, B, Boshuizen, Hc, Agudo, A, Berrino, F, Gram, It, Janson, L, Linseisen, J, Overvad, K, Rasmuson, T, Vineis, P, Lukanova, A, Allen, N, Amiano, P, Barricarte, A, Berglund, G, Boeing, H, CLAVEL CHAPELON, F, Day, Ne, Hallmans, G, Lund, E, Martinez, C, Navarro, C, Palli, D, Panico, Salvatore, Peeters, Ph, Quiros, Jr, Tjonneland, A, Tumino, R, Trichopoulou, A, Trichopoulos, D, Slimani, N, and Riboli, E.
Subjects: ddc:610
Published: 2004

5. Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study

Author: Kühn, T, Kaaks, R, Becker, S, Eomois, P-P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M-J, Menéndez, V, Chirlaque, M-D, Barricarte, A, Bueno-De-Mesquita, HB, Van Duijnhoven, FJB, Van Gils, CH, Bakker, MF, Weiderpass, E, Skeie, G, Brustad, M, Andersson, A, Sund, M, Wareham, N, Khaw, KT, Travis, RC, Schmidt, JA, Rinaldi, S, Romieu, I, Gallo, V, Murphy, N, Riboli, E, and Linseisen, J
Subjects: Hormone Replacement Therapy, Nutritional Status, Breast Neoplasms, Body Mass Index, Europe, Receptors, Estrogen, 25-hydroxyvitamin D, breast cancer, estrogen receptor status, prospective study, vitamin D, Risk Factors, Case-Control Studies, Body Composition, Humans, Female, Prospective Studies, ddc:610, Vitamin D
Abstract: Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season-standardized 25(OH)D levels and the risk of breast cancer (ORQ4-Q1 [95% CI]: 1.07 [0.85-1.36], ptrend = 0.67). Moreover, 25(OH)D levels were not related to the risks of estrogen receptor positive tumors (ORQ4-Q1 [95% CI]: 0.97 [0.67-1.38], p trend = 0.90) and estrogen receptor negative tumors (OR Q4-Q1 [95% CI]: 0.97 [0.66-1.42], ptrend = 0.98). In hormone replacement therapy (HRT) users, 25(OH)D was significantly inversely associated with incident breast cancer (ORlog2 [95% CI]: 0.62 [0.42-0.90], p = 0.01), whereas no significant association was found in HRT nonusers (ORlog2 [95% CI]: 1.14 [0.80-1.62], p = 0.48). Further, a nonsignificant inverse association was found in women with body mass indices (BMI) < 25 kg/m2 (ORlog2 [95% CI]: 0.83 [0.67-1.03], p = 0.09), as opposed to a borderline significant positive association in women with BMI ≥ 25 kg/m2 (ORlog2 [95% CI]: 1.30 [1.0-1.69], p = 0.05). Overall, prediagnostic levels of circulating 25(OH)D were not related to the risk of breast cancer in the EPIC study. This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer. What's new? Experimental studies have indicated that vitamin D may play a role in preventing tumor formation in the breast. However, in the present investigation, the largest prospective case-control study on circulating 25-hydroxyvitamin D (25(OH)D) and breast cancer risk conducted to date, pre-diagnostic levels of 25(OH)D were found to be unrelated to overall breast cancer risk. While the results support those of similar prospective studies, a significant inverse association was detected between 25(OH)D levels and incident breast cancer in women taking hormone replacement therapy, suggesting that background factors may influence risk associations. © 2013 UICC.
Published: 2013

6. Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort

Author: Gallo, V., Bueno de Mesquita, H.B., Vermeulen, R.C.H., Andersen, P.M., Kyrozis, A., Linseisen, J., Kaaks, R., Allen, N.E., Roddam, A.W., Boshuizen, H.C., Peeters, P.H.M., Palli, D., Mattiello, A., Sieri, S., Tumino, R., Jimenez-Martin, J.M., Diaz, M.J., Suarez, L.R., Trichopoulou, A., Agudo, A., Arriola, L., Barricante-Gurrea, A., Bingham, S., Khaw, K.T., Manjer, J., Lindkvist, B., Overvad, K., Bach, F.W., Tjonneland, A., Olsen, A., Bergmann, M.M., Boeing, H., Clavel-Chapelon, F., Lund, E., Hallmans, G., Middleton, L., Vineis, P., Riboli, E., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
Subjects: Adult, Male, Questionnaires, Risk, medicine.medical_specialty, International Cooperation, Cohort Studies, Sex Factors, Internal medicine, medicine, Humans, ddc:610, Amyotrophic lateral sclerosis, Risk factor, Aged, Proportional Hazards Models, business.industry, Proportional hazards model, Mortality rate, Amyotrophic Lateral Sclerosis, Smoking, Age Factors, Middle Aged, Former Smoker, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Neurology, Cohort, Physical therapy, Female, Neurology (clinical), business, Cohort study
Abstract: Udgivelsesdato: 2009-Apr OBJECTIVE: Cigarette smoking has been reported as "probable" risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age-specific mortality rates from ALS and the role of cigarette smoking on the risk of dying from ALS. METHODS: A total of 517,890 healthy subjects were included, resulting in 4,591,325 person-years. ALS cases were ascertained through death certificates. Cox hazard models were built to investigate the role of smoking on the risk of ALS, using packs/years and smoking duration to study dose-response. RESULTS: A total of 118 subjects died from ALS, resulting in a crude mortality rate of 2.69 per 100,000/year. Current smokers at recruitment had an almost two-fold increased risk of dying from ALS compared to never smokers (HR = 1.89, 95% C.I. 1.14-3.14), while former smokers at the time of enrollment had a 50% increased risk (HR = 1.48, 95% C.I. 0.94-2.32). The number of years spent smoking increased the risk of ALS (p for trend = 0.002). Those who smoked more than 33 years had more than a two-fold increased risk of ALS compared with never smokers (HR = 2.16, 95% C.I. 1.33-3.53). Conversely, the number of years since quitting smoking was associated with a decreased risk of ALS compared with continuing smoking. INTERPRETATION: These results strongly support the hypothesis of a role of cigarette smoking in aetiology of ALS. We hypothesize that this could occur through lipid peroxidation via formaldehyde exposure.
Published: 2009

7. Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition

Author: Hermann, S., Rohrmann, S., Linseisen, J., Nieters, A., Khan, A., Gallo, V., Overvad, K., Tjonneland, A., Raaschou-Nielsen, O., Bergmann, M.M., Boeing, H., Becker, N., Kaaks, R., Bueno-de-Mesquita, H.B., May, A.M., Vermeulen, R.C.H., Bingham, S, Khaw, K.T., Key, T.J., Travis, R.C., Trichopoulou, A., Georgila, C., Triantafylou, D., Celentano, E., Krogh, V., Masala, G., Tumino, R., Agudo, A., Altzibar, J.M., Ardanaz, E., Martinez-Garcia, C., Arguelles, M.V., Tormo, M.J., Braaten, T., Lund, E., Manjer, J., Zackrisson, S., Hallmans, G., Malmer, B., Boffetta, P., Brennan, P., Slimani, N., Vineis, P., Riboli, E., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Hermann, S., Rohrmann, S., Linseisen, J., Nieters, A., Khan, A., Gallo, V., Overvad, K., Tjønneland, A., Raaschou-Nielsen, O., Bergmann, M.M., Boeing, H., Becker, N., Kaaks, R., Bas Bueno-De-Mesquita, H., May, A.M., Vermeulen, R.C.H., Bingham, S., Khaw, K.-T., Key, T.J., Travis, R.C., Trichopoulou, A., Georgila, C., Triantafylou, D., Celentano, E., Krogh, V., Masala, G., Tumino, R., Agudo, A., Altzibar, J.M., Ardanaz, E., Martínez-García, C., Suárez, M.V.A., Tormo, M.J., Braaten, T., Lund, E., Manjer, J., Zackrisson, S., Hallmans, G., Malmer, B., Boffetta, P., Brennan, P., Slimani, N., Vineis, P., and Riboli, E.
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, lymphoma, European, Risk Assessment, Sex Factors, Risk Factors, immune system diseases, Surveys and Questionnaires, Internal medicine, hemic and lymphatic diseases, Prevalence, medicine, Humans, cancer, Prospective Studies, ddc:610, Risk factor, Prospective cohort study, Proportional Hazards Models, education, business.industry, Incidence, Lymphoma, Non-Hodgkin, Incidence (epidemiology), General Medicine, Middle Aged, medicine.disease, Hodgkin Disease, Leukemia, Lymphocytic, Chronic, B-Cell, Diet, Non-Hodgkin's lymphoma, European Prospective Investigation into Cancer and Nutrition, Lymphoma, Europe, nutrition, Immunology, Educational Status, Female, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma, Cohort study
Abstract: Introduction: Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. Materials and methods: Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. Results: Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. Conclusion: We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded. © 2009 Springer-Verlag.
Published: 2010

8. Modified Mediterranean diet and survival after myocardial infarction

Author: Y. T. van der Schouw, Philippos Orfanos, B. Van Guelpen, V. Pala, C. A. Gonzalez, Petra H.M. Peeters, Anne Tjønneland, María José Sánchez, Antonia Trichopoulou, Vassiliki Benetou, S Bingham, Timothy J. Key, S. Rohrmann, Theodora Psaltopoulou, Kay-Tee Khaw, Christina Bamia, Kim Overvad, Erik Berg Schmidt, Concha Moreno, Nerea Larrañaga, F. Clavel-Chapelon, J. Linseisen, Salvatore Panico, J. H. Jansson, M. C. Boutron-Ruault, M-D Chirlaque, Teresa Norat, Giovanna Masala, Jytte Halkjær, Cornelia Weikert, H. Boeing, Paolo Boffetta, Dimitrios Trichopoulos, R. Tumino, Carlotta Sacerdote, Marga C. Ocké, Marie-Noël Vercambre, H. B. Bueno-De-Mesquita, Elio Riboli, E. A. Spencer, Trichopoulou, A, Bamia, C, Norat, T, Overvad, K, Schmidt, Eb, Tjonneland, A, Halkjaer, J, CLAVEL CHAPELON, F, Vercambre, Mn, BOUTRON RUAULT, Mc, Linseisen, J, Rohrmann, S, Boeing, H, Weikert, C, Benetou, V, Psaltopoulou, T, Orfanos, P, Boffetta, P, Masala, G, Pala, V, Panico, Salvatore, Tumino, R, Sacerdote, C, BUENO DE MESQUITA, Hb, Ocke, Mc, Peeters, Ph, VAN DER SCHOUW, Yt, Gonzalez, C, Sanchez, Mj, Chirlaque, Md, Moreno, C, Larranaga, N, VAN GUELPEN, B, Jansson, Jh, Bingham, S, Khaw, Kt, Spencer, Ea, Key, T, Riboli, E, Trichopoulos, D., Trichopoulou, A., Bamia, C., Norat, T., Overvad, K., Schmidt, E.B., Tjønneland, A., Halkjær, J., Clavel-Chapelon, F., Vercambre, M.-N., Boutron-Ruault, M.-C., Linseisen, J., Rohrmann, S., Boeing, H., Weikert, C., Benetou, V., Psaltopoulou, T., Orfanos, P., Boffetta, P., Masala, G., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, H.B., Ocke, M.C., Peeters, P.H., Van Der Schouw, Y.T., González, C., Sanchez, M.J., Chirlaque, M.D., Moreno, C., Larrañaga, N., Van Guelpen, B., Jansson, J.-H., Bingham, S., Khaw, K.-T., Spencer, E.A., Key, T., Riboli, E., and University of Groningen
Subjects: Male, COUNTRIES, medicine.medical_specialty, Mediterranean diet, Epidemiology, ALCOHOL, Diet, Mediterranean, survival, elderly, Modified Mediterranean diet survival myocardial infarction EPIC-Elderly study, Food group, PEOPLE, medicine, Humans, CORONARY-HEART-DISEASE, COHORT, Prospective Studies, Myocardial infarction, ddc:610, Survival rate, Aged, Proportional Hazards Models, RISK, business.industry, Proportional hazards model, Mortality rate, MORTALITY, Middle Aged, Nutrition Surveys, medicine.disease, CANCER, European Prospective Investigation into Cancer and Nutrition, Surgery, Europe, Survival Rate, Standardized mortality ratio, myocardial infarction, Female, NUTRITION, business, FOLLOW-UP, Demography
Abstract: Mediterranean diet is associated with lower incidence of coronary heart disease, and two randomised trials indicated that it improves prognosis of coronary patients. These trials, however, relied on a total of 100 deaths and evaluated designer diets in the clinical context. We have evaluated the association of adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, with survival among elderly with previous myocardial infarction within the European Prospective Investigation into Cancer and nutrition (EPIC) study. As of December 2003, after a median follow-up of 6.7 years, 2671 EPIC participants from nine countries were 60 years or older and had prevalent myocardial infarction but no stroke or cancer at enrolment, complete information on dietary intakes and important covariates and known survival status. Adherence to the modified Mediterranean diet was assessed through a 10-unit-scale. Mortality ratio in relation to modified Mediterranean diet was estimated through Cox regression controlling for possible confounding. Increased adherence to modified Mediterranean diet by two units was associated with 18% lower overall mortality rate (95% confidence interval 7-27%, fixed effects model). There was no significant heterogeneity by sex, age at enrolment, or country, although the association tended to be less evident among northern Europeans. Associations between food groups contributing to the modified Mediterranean diet and mortality were generally weak. A diet inspired by the Mediterranean pattern that can be easily adopted by Western populations is associated with substantial reduction of total mortality of coronary patients in the community. © 2007 Springer Science+Business Media B.V.
Published: 2007

9. Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition

Author: Pietro Ferrari, Dagrun Engeset, Timothy J. Key, Kuanrong Li, Anne Tjønneland, Kim Overvad, José María Huerta, H. Bas Bueno-de-Mesquita, Christine L. Parr, Guri Skeie, Pilar Amiano, Kay-Tee Khaw, Teresa Norat, Göran Hallmans, Anne C. Vergnaud, Isabelle Romieux, Fulvio Ricceri, M. Luisa Redondo, Dimitirios Trichopoulos, Rosario Tumino, Veronika Fedirko, Françoise Clavel-Chapelon, Elio Riboli, Androniki Naska, Rikke Egeberg, Nicholas J. Wareham, Marianne Uhre Jakobsen, Emily Sonestedt, Heiner Boeing, Aurelio Barricarte, Salvatore Panico, Max Leenders, Manuela M. Bergmann, Laura Nailler, Isabel Drake, Paula Jakszyn, Marie-Christine Boutron-Ruault, Domenico Palli, Sabine Rohrmann, Vittorio Krogh, Antonia Trichopoulou, María José Sánchez, Jakob Linseisen, Petra H.M. Peeters, Ingegerd Johansson, Francesca L. Crowe, Rudolf Kaaks, Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, University of Zurich, Rohrmann, Sabine, [Rohrmann,S] Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland. [Rohrmann,S., Li,K, Kaaks,R, Linseisen,J] Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany. [Overvad,K, Jakobsen,MU] Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. [Bueno-de-Mesquita,HB] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.[Bueno-de-Mesquita, HB, Leenders,M] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. [Egeberg,R, Tjønneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Nailler,L, Boutron-Ruault,MC, Clavel-Chapelon,F] Inserm, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif, France. [Nailler,L, Clavel-Chapelon,F] Paris South University, UMRS, Villejuif, France. [Krogh,V] Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. [Palli,D] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. [Panico,S] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civile - M.P.Arezzo' Hospital, Ragusa, Italy. [Ricceri,F] HuGeF - Human Genetics Foundation - Torino, Torino, Italy. [Bergmann,MM, Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany. [Khaw,KT] Department of Public Health and Primary Care, University of Cambridge, Cambridge UK. [Wareham,NJ] Medical Research Council (MRC) Epidemiology Unit, Cambridge UK. [Crowe,FL, Key,TJ] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. [Naska,A, Trichopoulou,A] WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Trichopoulou,A, Trichopoulos,D] Hellenic Health Foundation, Athens, Greece. [Trichopoulos,D] Department of Epidemiology, Harvard School of Public Health, Boston MA, USA.Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [Peeters,PHM] Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands. [Peeters,PHM, Norat,T, Vergnaud,AC, Riboli,E] School of Public Health, Imperial College, London, UK. [Engeset,D, Skeie,G] Department of Community Medicine, University of Tromsø, Tromsø, Norway. [Parr,CL] Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway. [Jakszyn,P] Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Barcelona, Spain. [Sánchez,MJ, Huerta,JM] Andalusian School of Public Health, Granada, Spain. [Sánchez,MJ, Barricarte,A, Amiano,P] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Redondo,ML] Public Health Directorate Asturias, Oviedo, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Amiano,P] Public Health Division of Gipuzkoa, BIODonostia Research Institute, Department of Health of the Regional Government of the Basque Country, San Sebastian, Spain. [Drake,I, Sonestedt,E] Department of Clinical Sciences, Lund University, Malmö, Sweden. [Hallmans,G] Department of Public Health and Clinical Medicine, Nutrition Research, Umeå University, Umeå, Sweden. [Johansson,I] Department of Odontology, Cariology, Umeå University, Umeå, Sweden. [Fedirko,V, Romieux,I, Ferrari,P] International Agency for Research on Cancer (IARC), Lyon, France. [Linseisen,J] Institute of Epidemiology, Helmholtz Centre Munich, Neuherberg, Germany., Europe Against Cancer Program of the European Commission (SANCO), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research, Danish Cancer Society, Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, ISCIII RCESP exp. C03/09, Spain, Cancer Research UK, Medical Research Council, United Kingdom, Stroke Association, United Kingdom, British Heart Foundation, Department of Health, United Kingdom, Food Standards Agency, United Kingdom, Wellcome Trust, United Kingdom, the Hellenic Health Foundation and the Stavros Niarchos Foundation, Italian Association for Research on Cancer (AIRC), Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy, Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), Swedish Cancer Society, Swedish Scientific Council, Regional Government of Skåne, Sweden, Nordforsk the Norwegian Cancer Society, French League against Cancer (LNCC), National Institute for Health and Medical Research (INSERM), France, Mutuelle Générale de l’Education Nationale (MGEN), France, 3M Co, France, Gustave Roussy Institute (IGR), France, and General Councils of France, BMC, Ed., Division of Cancer Epidemiology and Prevention, Universität Zürich [Zürich] = University of Zurich (UZH)-Institute of Social and Preventive Medicine, Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Section of Epidemiology, Aarhus University [Aarhus], Department of Gastroenterology and Hepatology, University Medical Centre, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Department of Clinical and Experimental Medicine, University of Naples Federico II = Università degli studi di Napoli Federico II, Cancer Registry and Histopathology Unit, Civile - M.P.Arezzo Hospital, HuGeF - Human Genetics Foundation - Torino, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Epidemiology Unit, Medical Research Council, Cancer Epidemiology Unit, University of Oxford, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School [Athens], Hellenic Health Foundation, Harvard School of Public Health, Bureau of Epidemiologic Research, Academy of Athens, Julius Center, University Medical Center [Utrecht], School of Public Health, Imperial College London, Department of Community Medicine, University of Tromsø (UiT), Department of Biostatistics [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Andalusian School of Public Health [Granada], Consortium for Biomedical Research in Epidemiology and Public Health, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council, Public Health Directorate Asturias, Navarre Public Health Institute, Public Health Division of Gipuzkoa, BIODonostia Research Institute, Department of Clinical Sciences, Lund University [Lund], Department of Public Health and Clinical Medicine, Umeå University, Department of Odontology, Cariology, International Agency for Cancer Research (IACR), Institute of Epidemiology, Helmholtz Centre Munich, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli studi di Napoli Federico II, University of Oxford [Oxford], Rohrmann, S, Overvad, K, Bueno de Mesquita, Hb, Jakobsen, Mu, Egeberg, R, Tj?nneland, A, Nailler, L, Boutron Ruault, Mc, Clavel Chapelon, F, Krogh, V, Palli, D, Panico, Salvatore, Tumino, R, Ricceri, F, Bergmann, Mm, Boeing, H, Li, K, Kaaks, R, Khaw, Kt, Wareham, Nj, Crowe, Fl, Key, Tj, Naska, A, Trichopoulou, A, Trichopoulos, D, Leenders, M, Peeters, Ph, Engeset, D, Parr, Cl, Skeie, G, Jakszyn, P, S?nchez, Mj, Huerta, Jm, Redondo, Ml, Barricarte, A, Amiano, P, Drake, I, Sonestedt, E, Hallmans, G, Johansson, I, Fedirko, V, Romieux, I, Ferrari, P, Norat, T, Vergnaud, Ac, Riboli, E, and Linseisen, J.
Subjects: Male, 030309 nutrition & dietetics, Colorectal cancer, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis [Medical Subject Headings], Review, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], 2700 General Medicine, DISEASE, COLORECTAL-CANCER, VDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Cohort Studies, Diet, Meat, Mortality, Cohort, Europe, Cardiovascular, Cancer, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Nutrition Surveys [Medical Subject Headings], 0302 clinical medicine, Neoplasms, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Medicine(all), RISK, CALIBRATION, 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, cardiovascular, Diabetes, Hazard ratio, food and beverages, cohort, General Medicine, Diseases::Neoplasms [Medical Subject Headings], Middle Aged, Nutrition Surveys, Neoplasias, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Näringslära, Cardiovascular Diseases, Red meat, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, Enfermedades cardiovasculares, Life Sciences & Biomedicine, Geographicals::Geographic Locations::Americas::North America::United States [Medical Subject Headings], CERTIFICATES, Research Article, Cohort study, Technology, Industry, Agriculture::Food and Beverages::Food::Meat [Medical Subject Headings], Adult, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Processed meat, Estudios de cohortes, Check Tags::Male [Medical Subject Headings], 610 Medicine & health, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings], VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811, VEGETARIANS, 03 medical and health sciences, Medicine, General & Internal, General & Internal Medicine, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], medicine, cancer, Humans, ddc:610, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Aged, Science & Technology, business.industry, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Feeding Behavior, medicine.disease, mortality, Survival Analysis, United States, Surgery, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, RED MEAT, Check Tags::Female [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Commentary, 21-YEAR FOLLOW-UP, business, Body mass index, Demography
Abstract: Background Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods Included in the analysis were 448,568 men and women without prevalent cancer, stroke, or myocardial infarction, and with complete information on diet, smoking, physical activity and body mass index, who were between 35 and 69 years old at baseline. Cox proportional hazards regression was used to examine the association of meat consumption with all-cause and cause-specific mortality. Results As of June 2009, 26,344 deaths were observed. After multivariate adjustment, a high consumption of red meat was related to higher all-cause mortality (hazard ratio (HR) = 1.14, 95% confidence interval (CI) 1.01 to 1.28, 160+ versus 10 to 19.9 g/day), and the association was stronger for processed meat (HR = 1.44, 95% CI 1.24 to 1.66, 160+ versus 10 to 19.9 g/day). After correction for measurement error, higher all-cause mortality remained significant only for processed meat (HR = 1.18, 95% CI 1.11 to 1.25, per 50 g/d). We estimated that 3.3% (95% CI 1.5% to 5.0%) of deaths could be prevented if all participants had a processed meat consumption of less than 20 g/day. Significant associations with processed meat intake were observed for cardiovascular diseases, cancer, and 'other causes of death'. The consumption of poultry was not related to all-cause mortality. Conclusions The results of our analysis support a moderate positive association between processed meat consumption and mortality, in particular due to cardiovascular diseases, but also to cancer.
Published: 2013

10. The association of education with body mass index and waist circumference in the EPIC-PANACEA study

Author: Amalia Mattiello, Marianne Uhre Jakobsen, Noémie Travier, Dora Romaguera, Rosario Tumino, Jakob Linseisen, Kim Overvad, Giovanna Masala, Rudolf Kaaks, Aurelio Barricarte, Petra H.M. Peeters, Sabina Rinaldi, Silke Hermann, Petra G. Van Boeckel, Jytte Halkjær, Miren Dorronsoro, Bethany Van Guelpen, Esther Molina, Ingegerd Johansson, Francesca L. Crowe, Anne M. May, Paolo Vineis, Anton E. Kunst, Nadia Slimani, Claudia Agnoli, Signe Borgquist, Philippos Orfanos, H. Bas Bueno-de-Mesquita, Traci Mouw, Antonia Trichopoulou, Françoise Clavel-Chapelon, Elio Riboli, Teresa Norat, Manuela M. Bergmann, Kay-Tee Khaw, Tonje Braaten, Androniki Naska, Laudina Rodríguez, Sabine Rohrmann, Hervé Besson, Guy Fagherazzi, Annika Steffen, Anne Tjønneland, María José Tormo, Jonas Manjer, Nicholas J. Wareham, Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Social and Preventive Medicine Institute, Universität Zürich [Zürich] = University of Zurich (UZH), Institute of Epidemiology, Helmholtz Centre Munich, Julius Centre for Health Sciences and Primary Care, University Medical Center [Utrecht], National Institute for Public Health and the Environment [Bilthoven] (RIVM), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Medical Research Council, Institute of Metabolic Science-Epidemiology Unit, Department of Epidemiology & Public Health, Imperial College London, Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology-Environment and Cancer, Epidemiology Service, Murcia Health Council, Preventive Medicine and Public Health Unit, Murcia Medical School, CIBER Epidemiología y Salud Pública (CIBERESP), CIBER de Epidemiología y Salud Pública (CIBERESP), Andalusian School of Public Health [Granada], Public Health Department of Gipuzkoa, Public Health Institute of Navarra, Public Health and Participation Directorate, Health and Health Care Services Council, Cancer Epidemiology Unit, University of Oxford, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Cardiology, Aarhus University Hospital, Department of Clinical Epidemiology, Danish Cancer Society, Institute of Cancer Epidemiology, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Clinical and Experimental Medicine, University of Naples Federico II = Università degli studi di Napoli Federico II, Cancer Registry and Histopathology Unit, Department of Oncology-Civile - M.P.Arezzo Hospital, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), ISI Foundation Institute for Scientific Interchange, Environmental Epidemiology, Department of Hygiene and Epidemiology, University of Athens Medical School [Athens], Hellenic Health Foundation, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association, Department of Medical Biosciences and Pathology, Umeå University, Department of Odontology, Department of Oncology, Lund University Hospital, Department of Surgery, Malmö University Hospital, Institute of Community Medicine, University of Tromsø (UiT), Nutrition, hormones et cancer: épidémiologie et prévention (E3N), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The work was further financially supported by the European Commission: Public Health and Consumer Protection Directorate 1993-2004, Research Directorate-General 2005-.', Ligue contre le Cancer, Societé 3M, Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research (Germany), Danish Cancer Society (Denmark), Health Research Fund (FIS) of the Spanish Ministry of Health, The participating regional governments and institutions (Spain), Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, the Wellcome Trust (United Kingdom), Greek Ministry of Health and Social Solidarity, Hellenic Health Foundation and Stavros Niarchos Foundation (Greece), Italian Association for Research on Cancer, National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports, Dutch Ministry of Health, Dutch Prevention Funds, LK Research Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (the Netherlands), Swedish Cancer Society, Swedish Scientific Council, Regional Government of Skane (Sweden), Norwegian Cancer Society (Norway)., BMC, Ed., University of Zurich, Rohrmann, S, University of Oxford [Oxford], Università degli studi di Napoli Federico II, [Hermann,S, Rohrmann,S, Linseisen,J, Kaaks,R] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany. [Linseisen,J] Helmholtz Ctr Munich, Inst Epidemiol, Neuherberg, Germany. [May,AM., Besson,H, Peeters,PH.M.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [May,AM., van Boeckel,PG.A., Bueno-de-Mesquita,H.B] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Kunst,A] Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands. [Besson,H, Wareham,NJ.] MRC, Inst Metab Sci, Epidemiol Unit, Cambridge, England. [Romaguera,D, Mouw,T, Norat,T, Riboli,E] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England. [Travier,N] IDIBELL, Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain. [Tormo,MJ] Murcia Hlth Council, Epidemiol Serv, Murcia, Spain. [Tormo,MJ] Murcia Med Sch, Prevent Med & Publ Hlth Unit, Murcia, Spain. [Molina,E] Andalusian Sch Publ Hlth, Granada, Spain. [Dorronsoro,M] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain. [Barricarte,A] Publ Hlth Inst Navarra, Pamplona, Spain. [Rodriguez,L] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Crowe,FL.] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Khaw,K-T] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. [Overvad,K] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark. [Overvad,K, Jakobsen,MU] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark. [Tjonneland,A, Halkjaer,J] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Agnoli,C] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy. [Mattiello,A] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy. [Tumino,R] Civile MP Arezzo Hosp, Dept Oncol, Canc Registry & Histopathol Unit, Ragusa, Italy. [Masala,G] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Vineis,P] ISI Fdn, Turin, Italy. [Naska,A, Orfanos,P, Trichopoulou,A] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece. [Bergmann,MM., Steffen,A] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany. [Van Guelpen,B] Umea Univ, Dept Med Biosci, Umea, Sweden. [Johansson,I] Umea Univ, Dept Odontol, Umea, Sweden. [Borgquist,S] Univ Lund Hosp, Dept Oncol, Lund, Sweden. [Manjer,J] Malmo Univ Hosp, Dept Surg, Malmo, Sweden. [Braaten,T] Univ Tromso, Inst Community Med, Tromso, Norway. [Fagherazzi,G, Clavel-Chapelon,F] Paris S Univ, Inst Gustave Roussy, Villejuif, France. [Fagherazzi,G, Clavel-Chapelon,F] INSERM, ERI20, Villejuif, France. [Besson,H, Rinaldi,S, Slimani,N] Int Agcy Res Canc, Lyon, France. [Rohrmann,S] Univ Zurich, Inst Social & Prevent Med, Zurich, Switzerland, European Commission: Grant no DG Sanco, project number: 2005328. The work was further financially supported by the European Commission: Public Health and Consumer Protection Directorate 1993-2004, Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Faculteit der Geneeskunde, APH - Amsterdam Public Health, and Public and occupational health
Subjects: Male, Epidemiology, Body Mass Index, VDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811, 0302 clinical medicine, Prospective Studies, Public, Environmental & Occupational Health, MESH: Middle Aged, 3. Good health, MESH: Health Status Disparities, MESH: Waist Circumference, Socioeconomic status, Waist circumference, Public Health, Waist Circumference, Cohort study, VDP::Medisinske Fag: 700::Helsefag: 800::Medisinsk/odontologisk etikk, atferdsfag, historie: 805, Waist, Pes corporal, Education, MESH: Body Mass Index, VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811, 03 medical and health sciences, MESH: Sex Factors, cohort study, Humans, Aged, Science & Technology, MESH: Humans, Prevention, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, MESH: Adult, Body weight, medicine.disease, Obesity, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Index [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings], ENERGY-INTAKE, OXFORD PARTICIPANTS, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI, Educació, MESH: Educational Status, Body mass index, MESH: Female, Demography, Gerontology, Overweight, SOCIOECONOMIC-STATUS, 030212 general & internal medicine, 2. Zero hunger, MESH: Aged, education, Bmi, Cohort Study, Epic, Socioeconomic Status, lcsh:Public aspects of medicine, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, Circumference, CANCER, PREVALENCE, European Prospective Investigation into Cancer and Nutrition, Europe, OBESITY, Educational Status, Female, medicine.symptom, Life Sciences & Biomedicine, Research Article, Adult, VDP::Medical disciplines: 700::Health sciences: 800::Medical/dental ethics, behavioural sciences, history: 805, 030209 endocrinology & metabolism, 610 Medicine & health, socioeconomic status, BMI, Sex Factors, Eating disorders and obesity, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings], medicine, ddc:610, Nutrition, OVERWEIGHT, business.industry, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Health Status Disparities [Medical Subject Headings], Health Status Disparities, ADULTS, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2739 Public Health, Environmental and Occupational Health, MESH: Prospective Studies, MESH: Male, PHYSICAL-ACTIVITY, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, WEIGHT STATUS, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, EPIC, business
Abstract: Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four categories; BMI and WC, measured by trained personnel in most participating centers, were modeled as continuous dependent variables. Associations were estimated using multilevel mixed effects linear regression models. Results Compared with the lowest education level, BMI and WC were significantly lower for all three higher education categories, which was consistent for all countries. Women with university degree had a 2.1 kg/m2 lower BMI compared with women with lowest education level. For men, a statistically significant, but less pronounced difference was observed (1.3 kg/m2). The association between WC and education level was also of greater magnitude for women: compared with the lowest education level, average WC of women was lower by 5.2 cm for women in the highest category. For men the difference was 2.9 cm. Conclusion In this European cohort, there is an inverse association between higher BMI as well as higher WC and lower education level. Public Health Programs that aim to reduce overweight and obesity should primarily focus on the lower educated population.
Published: 2011

11. A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Author: J. Ramón Quirós, Eva Ardanaz, Stefania Boccia, Wilbert H.M. Peters, Dimitrios Trichopoulos, Mario Foglio, Luigi Barzan, Lenka Foretova, Joshua E. Muscat, Françoise Clavel-Chapelon, Elio Riboli, Diana Zelenika, Paul Brennan, Salvatore Panico, Eleonora Fabianova, Lars J. Vatten, Kay-Tee Khaw, David I. Conway, Pilar Galan, Doris Lechner, Erich M. Sturgis, Shilong Zhong, Shama Buch, Jolanta Lissowska, Franco Merletti, Carmen Enid Martínez, Li E. Wang, H. Bas Bueno-de-Mesquita, Vittorio Krogh, Andres Metspalu, Anne Tjønneland, Shen Chih Chang, Rayjean J. Hung, Silvia Franceschi, Amelie Chabrier, Kristina Kjærheim, Gabriella Cadoni, Sergio Koifman, Ariana Znaor, Chu Chen, Pagona Lagiou, Ivana Holcatova, Richard B. Hayes, James McKay, Graham Byrnes, Philip Lazarus, Christine Bouchardy, Ray Lowry, Vladimir Bencko, Merethe Kumle, Jingchun Luo, Antonio Agudo, Mark Lathrop, David R. Doody, Victor Wünsch-Filho, Joanna Trubicka, Lorenzo Simonato, Martin Lacko, Cristina Canova, John K. Field, Sherianne Fish, Valerie Gaborieau, Xavier Castellsagué, Mary Toner, Thérèse Truong, Tomoko Nukui, Carla J. Gallagher, Wolfgang Ahrens, Triantafillos Liloglou, Kim Overvad, Vladimir Janout, Ivo Gut, Paolo Boffetta, Shu Chun Chuang, Göran Hallmans, Jakob Linseisen, Marjorie Romkes, David Zaridze, Mark C. Weissler, Simone Benhamou, Antonia Trichopoulou, Nerea Larrañaga, José Eluf Neto, Neonila Szeszenia-Dabrowska, Jan Lubinski, Stephen M. Schwartz, Peter Rudnai, Hélène Blanché, Mia Hashibe, William K. Funkhouser, Paolo Vineis, Maria Paula Curado, Gary J. Macfarlane, Marcin Lener, Claire M. Healy, Michael D. McClean, Domenico Palli, Marc Delepine, Tõnu Voodern, Carmen J. Marsit, Zuo-Feng Zhang, Kristjan Välk, Dorota Oszutowska, Heiner Boeing, Ana M. B. Menezes, Rolando Herrero, Leticia Fernández Garrote, Heather H. Nelson, Renato Talamini, Anne Boland, Alexandru Bucur, Qingyi Wei, Gary E. Goodman, Lorenzo Richiardi, Carmen Navarro, Karl T. Kelsey, Rosario Tumino, Inger Njølstad, Johannes J. Manni, Carlos A. González, Oxana Shangina, John R. McLaughlin, Patricia A. McKinney, Timothy J. Key, Andrew F. Olshan, Dario Arzani, Tatiana V. Macfarlane, Simon Heath, Petra H.M. Peeters, International Agency for Research on Cancer (IARC), Russian Academy of Medical Sciences, Department of Epidemiology, Institute of Occupational Medicine, Maria Skłodowska Curie Memorial Cancer Center, National Institute for Environment, Partenaires INRAE, Regional Authority of Public Health, Institute of Public Health, Charles University [Prague] (CU), Palacky University Olomouc, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute (RECAMO), National and Kapodistrian University of Athens (NKUA), The Netherlands Cancer Institute, Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Stabilité Génétique et Oncogenèse (UMR 8200), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Université de Genève (UNIGE), Bremen Institute for Prevention Research and Social Medicine (BIPS), University of Bremen, Universita di Torino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), General Hospital, Cancer Registry of Norway, School of Medicine and Dentistry, Universita di Padova, Imperial College London, Catalan Institute of Oncology, CIBER de Epidemiología y Salud Pública (CIBERESP), Newcastle University [Newcastle], Dental School, Centre for Epidemiology and Biostatistics, University of Leeds, NHS NSS ISD, School of Dental Science, University of Liverpool, National Institute of Public Health, National School of Public Health, Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Universidade de São Paulo (USP), Institute of Oncology and Radiobiology, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Institute of Hygiene, Università cattolica del Sacro Cuore [Milano] (Unicatt), University of North Carolina, Pomeranian Medical University, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Penn State College of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, University of California [Los Angeles] (UCLA), University of California, Anderson Cancer Center, The University of Texas Health Science Center at Houston (UTHealth), Instituto de Investigación Epidemiológica, Brown University, School of public health, The University of Hong Kong (HKU), Masonic Cancer Center, University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, University of Pittsburgh (DEPARTMENT OF MATHEMATICS), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Maastricht University [Maastricht], Radboud University Medical Center [Nijmegen], Mount Sinai Hospital [Toronto, Canada] (MSH), Cancer Care Ontario, Norwegian University of Science and Technology (NTNU), University of Tromsø (UiT), Piedmont Reference Center for Epidemiology and Cancer Prevention, Department of Epidemiology and Public Health, Institut National de la Santé et de la Recherche Médicale (INSERM), Istituto per lo Studio e la Prevezione Oncologica, Civile - M.P.Arezzo Hospital, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), INCa, France, US NCI [R01 CA092039 05/05S1], Benhamou, Simone, Bouchardy Magnin, Christine, Charles University in Prague, Università cattolica del Sacro Cuore [Roma] (Unicatt), Penn State System-Pennsylvania Commonwealth System of Higher Education (PCSHE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), [McKay, JD, Truong, T, Gaborieau, V, Chabrier, A, Chuang, SC, Byrnes, G, Curado, MP, Franceschi, S, Hashibe, M, Boffetta, P, Brennan, P] IARC, Lyon, France. [Zaridze, D, Shangina, O] Russian Acad Med Sci, Canc Res Ctr, Inst Carcinogenesis, Moscow, Russia. [Szeszenia-Dabrowska, N] Inst Occupat Med, Dept Epidemiol, Lodz, Poland. [Lissowska, J] M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland. [Lissowska, J] Inst Oncol, Warsaw, Poland. [Rudnai, P] Natl Inst Environm Hlth, Budapest, Hungary. [Fabianova, E] Reg Author Publ Hlth, Banska Bystrica, Slovakia. [Bucur, A] Inst Publ Hlth, Bucharest, Romania. [Bencko, V, Holcatova, I] Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic. [Janout, V] Palacky Univ, CR-77147 Olomouc, Czech Republic. [Foretova, L] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic. [Trichopoulos, D] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Benhamou, S] INSERM U946, Paris, France. [Benhamou, S] Inst Gustave Roussy, CNRS UMR8200, Villejuif, France. [Bouchardy, C] Univ Geneva, Geneva Canc Registry, Inst Social & Prevent Med, Geneva, Switzerland. [Ahrens, W] Univ Bremen, Bremen Inst Prevent Res & Social Med BIPS, Bremen, Germany. [Merletti, F, Richiardi, L] Univ Turin, Canc Epidemiol Unit, Turin, Italy. [Talamini, R] IRCCS, Natl Canc Inst, Aviano, Italy. [Barzan, L] Gen Hosp Pordenone, Pordenone, Italy. [Kjaerheim, K] Canc Registry Norway, Oslo, Norway. [Macfarlane, GJ, Macfarlane, TV] Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland. [Simonato, L, Canova, C] Univ Padua, Dept Environm Med & Publ Hlth, Padua, Italy. [Canova, C] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England. [Agudo, A, Castellsague, X] ICO, Barcelona, Spain. [Castellsague, X, Navarro, C, Ardanaz, E] CIBERESP, Madrid, Spain. [Lowry, R] Univ Newcastle Dent Sch, Newcastle Upon Tyne, Tyne & Wear, England. [Conway, DI] Univ Glasgow Dent Sch, Glasgow, Lanark, Scotland. [McKinney, PA] Univ Leeds Ctr Epidemiol & Biostat, Leeds, W Yorkshire, England. [McKinney, PA] NHS NSS ISD, Edinburgh, Midlothian, Scotland. [Healy, CM, Toner, ME] Trinity Coll Sch Dent Sci, Dublin, Ireland. [Znaor, A] Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia. [Koifman, S] Natl Sch Publ Hlth FIOCRUZ, Rio De Janeiro, Brazil. [Menezes, A] Univ Fed Pelotas, Pelotas, Brazil. [Wuensch, V, Neto, JE] Univ Sao Paulo, Sao Paulo, Brazil. [Garrote, LF] Inst Oncol & Radiobiol, Havana, Cuba. [Boccia, S, Cadoni, G, Arzani, D] Univ Cattolica Sacro Cuore, Inst Hyg, Rome, Italy. [Boccia, S] IRCCS San Raffaele Pisana, Rome, Italy. [Olshan, AF] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Weissler, MC, Funkhouser, WK, Luo, JC] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Lubinski, J, Trubicka, J, Lener, M, Oszutowska, D] Pomeranian Med Univ, Dept Genet & Pathomorphol, Int Hereditary Canc Ctr, Szczecin, Poland. [Oszutowska, D] Pomeranian Med Univ, Dept Hyg Epidemiol & Publ Hlth, Szczecin, Poland. [Schwartz, SM, Chen, C, Fish, S, Doody, DR, Goodman, GE] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Muscat, JE, Lazarus, P, Gallagher, CJ] Penn State Coll Med, Hershey, PA USA. [Chang, SC, Zhang, ZF] Univ Calif Los Angeles Sch Publ Hlth, Los Angeles, CA USA. [Wei, QY, Sturgis, EM, Wang, LE] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Herrero, R] Inst Invest Epidemiol, San Jose, Costa Rica. [Kelsey, KT, Marsit, CJ] Brown Univ, Providence, RI 02912 USA. [McClean, MD] Boston Univ Sch Publ Hlth, Boston, MA USA. [Nelson, HH] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA. [Romkes, M, Buch, S, Nukui, T, Zhong, SL] Univ Pittsburgh, Pittsburgh, PA USA. [Lacko, M, Manni, JJ] Maastricht Univ Med Ctr, Dept Otorhinolaryngol & Head & Neck Surg, Maastricht, Netherlands. [Peters, WHM] St Radboud Univ Nijmegen Med Ctr, Dept Gastroenterol, Nijmegen, Netherlands. [Hung, RJ] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [McLaughlin, J] Canc Care Ontario, Toronto, ON, Canada. [Vatten, L] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway. [Njolstad, I] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway. [Field, JK, Liloglou, T] Univ Liverpool Canc Res Ctr, Roy Castle Lung Canc Res Programme, Liverpool, Merseyside, England. [Vineis, P] Univ Turin, Serv Epidemiol Tumori, Turin, Italy. [Vineis, P] CPO Piemonte, Turin, Italy. [Vineis, P, Riboli, E] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England. [Clavel-Chapelon, F] E3N EPIC Grp Inst Gustave Roussy, INSERM, Villejuif, France. [Palli, D] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Tumino, R] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy. [Tumino, R] Azienda Osped Civile MP Arezzo, Histopathol Unit, Ragusa, Italy. [Krogh, V] Fdn IRCCS, Ist Nazl Tumori, Milan, Italy. [Panico, S] Univ Naples Federico 2, Dipartimento Med Clin & Sperimentale, Naples, Italy. [Gonzalez, CA] ICO, RETICC DR06 0020, IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain. [Quiros, JR] Principado Asturias, Consejeria Serv Sociales, Jefe Secc Informac Sanitaria, Oviedo, Spain. [Martinez, C] Escuela Andaluza Salud Publ, Granada, Spain. [Navarro, C] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain. [Ardanaz, E] Navarra Publ Hlth Inst, Pamplona, Spain. [Larranaga, N] Gobierno Vasco, Subdirecc Salud Publ Gipuzkoa, San Sebastian, Spain. [Khaw, KT] Univ Cambridge, Sch Clin Med, Cambridge, England. [Key, T] Univ Oxford, Canc Res UK, Oxford, England. [Bueno-de-Mesquita, HB] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Peeters, PHM] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands. [Trichopoulou, A] Univ Athens Sch Med, WHO Collaborating Ctr Nutr, Dept Hyg Epidemiol & Med Stat, Athens, Greece. [Linseisen, J] Helmholtz Ctr Munich, Inst Epidemiol, Neuherberg, Germany. [Linseisen, J] German Canc Res Ctr, Div Clin Epidemiol, D-6900 Heidelberg, Germany. [Boeing, H] Deutsch Inst Ernahrungsforsch, Dept Epidemiol, Potsdam, Germany. [Hallmans, G] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Overvad, K] Aarhus Univ, Dept Epidemiol & Social Med, Aarhus, Denmark. Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Kumle, M] Univ Hosp No Norway, Tromso, Norway. [Valk, K, Voodern, T, Metspalu, A] Univ Tartu, EE-50090 Tartu, Estonia. [Zelenika, D, Boland, A, Delepine, M, Foglio, M, Lechner, D, Gut, IG, Heath, S, Lathrop, M] Commissariat Energie Atom, Inst Genom, Ctr Natl Genotypage, Evry, France. [Blanche, H, Lathrop, M] Fdn Jean Dausset CEPH, Paris, France. [Galan, P] Univ Paris 13, INSERM INRA CNAM U557 U1125, Bobigny, France. [Hayes, RB] New York Univ Langone Med Ctr, New York, NY USA, Support for the central Europe and ARCAGE genome-wide studies and follow-up genotyping was provided by INCa, France. Additional funding for study coordination, genotyping of replication studies, and statistical analysis was provided by the US NCI (R01 CA092039 05/05S1)., Norges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for samfunnsmedisin, McKay, J.D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S.-C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Simonato, L., Canova, C., Agudo, A., Castellsagué, X., Lowry, R., Conway, D.I., McKinney, P.A., Healy, C.M., Toner, M.E., Znaor, A., Curado, M.P., Koifman, S., Menezes, A., Wünsch-Filho, V., Neto, J.E., Garrote, L.F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A.F., Weissler, M.C., Funkhouser, W.K., Luo, J., Lubinski, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S.M., Chen, C., Fish, S., Doody, D.R., Muscat, J.E., Lazarus, P., Gallagher, C.J., Chang, S.-C., Zhang, Z.-F., Wei, Q., Sturgis, E.M., Wang, L.-E., Franceschi, S., Herrero, R., Kelsey, K.T., McClean, M.D., Marsit, C.J., Nelson, H.H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J.J., Peters, W.H.M., Hung, R.J., McLaughlin, J., Vatten, L., Njølstad, I., Goodman, G.E., Field, J.K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., González, C.A., Quirós, J.R., Martínez, C., Navarro, C., Ardanaz, E., Larrañaga, N., Khaw, K.-T., Key, T., Bueno-de-Mesquita, H.B., Peeters, P.H.M., Trichopoulou, A., Linseisen, J., Boeing, H., Hallmans, G., Overvad, K., Tjønneland, A., Kumle, M., Riboli, E., Välk, K., Voodern, T., Metspalu, A., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Blanché, H., Gut, I.G., Galan, P., Heath, S., Hashibe, M., Hayes, R.B., Boffetta, P., Lathrop, M., Brennan, P., Promovendi PHPC, Metamedica, KNO, RS: MHeNs School for Mental Health and Neuroscience, and RS: GROW - School for Oncology and Reproduction
Subjects: Male, Cancer Research, Candidate gene, Linkage disequilibrium, [SDV]Life Sciences [q-bio], Genome-wide association study, FAMILY-HISTORY, genome-wide, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study [Medical Subject Headings], 0302 clinical medicine, Gene Frequency, NECK-CANCER, Risk Factors, Càncer, SUSCEPTIBILITY LOCUS, SENSITIVITY PROTEIN MUS308, Genetics (clinical), Cancer, Genetics & Heredity, Genetics, Publication Characteristics::Study Characteristics::Multicenter Study [Medical Subject Headings], 0303 health sciences, TOBACCO-RELATED CANCERS, Tumor, Continental Population Groups, Middle Aged, 3. Good health, LUNG-CANCER, POOLED ANALYSIS, EPIDEMIOLOGY CONSORTIUM, INTERNATIONAL HEAD, ALCOHOL-DRINKING, Head and Neck Neoplasms, Drinking of alcoholic beverages, 030220 oncology & carcinogenesis, NEOPLASIAS, Consum d'alcohol, Head and Neck Neoplasms/enzymology/epidemiology/genetics, Genetics and Genomics/Gene Discovery, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Life Sciences & Biomedicine, Medical Genetics, Research Article, Adult, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714, Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms [Medical Subject Headings], lcsh:QH426-470, Neoplasias de Cabeza y Cuello, VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical genetics: 714, Genetics and Genomics/Complex Traits, Biology, association study, Estudio de Asociación del Genoma Completo, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings], 03 medical and health sciences, upper aerodigestive tract, Genetic variation, Biomarkers, Tumor, medicine, cancers, cancer, Humans, Genetic Predisposition to Disease, ddc:610, Tumor Markers, Biological/genetics, Genetics and Genomics/Cancer Genetics, Molecular Biology, Genotyping, Allele frequency, Settore MED/42 - IGIENE GENERALE E APPLICATA, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Genetic association, ddc:613, Aged, Medicinsk genetik, Estudio Multicéntrico, Science & Technology, Racial Groups, Genetic Variation, Aldehyde Dehydrogenase, medicine.disease, lcsh:Genetics, Aldehyde Dehydrogenase/genetics, Genome-Wide Association Study, Persons::Persons::Population Groups::Continental Population Groups [Medical Subject Headings], INHANCE consortium, sensitivity protein mus308, tobacco-related cancers, lung-cancer, pooled analysis, susceptibility locus, neck-cancer, epidemiology consortium, international head, alcohol-drinking, family-history, INHANCE Consortium, Biomarkers, Genètica
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility., Author Summary We have used a two-phased study approach to identify common genetic variation involved in susceptibility to upper aero-digestive tract cancer. Using Illumina HumanHap300 beadchips, 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls, were genotyped for a panel 317,000 genetic variants that represent the majority of common genetic in the human genome. The 19 top-ranked variants were then studied in an additional series of 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies. Five variants were significantly associated with UADT cancer risk after the completion of both stages, including three residing within the alcohol dehydrogenase genes (ADH1B, ADH1C, ADH7) that have been previously described. Two additional variants were found, one near the ALDH2 gene and a second variant located in HEL308, a DNA repair gene. These results implicate two variants 4q21 and 12q24 and further highlight three ADH variants UADT cancer susceptibility.
Published: 2011

12. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study

Author: Jakob Linseisen, Pierre Hainaut, Antonia Trichopoulou, Eiliv Lund, Pietro Ferrari, Sophie Morois, Kay-Tee Khaw, Kim Overvad, Philippe Autier, Gesthimani Misirli, Dimitrios Trichopoulos, Timothy J. Key, Andrew W. Roddam, Carla H. van Gils, Salvatore Panico, María J. Tormo, Paolo Vineis, Graham Byrnes, Eugene Jansen, Fränzel J.B. Van Duijnhoven, María José Sánchez, Martine M. Ros, Teresa Norat, Anja Olsen, Anne Tjønneland, Rudolf Kaaks, H. Bas Bueno-de-Mesquita, Tobias Pischon, Göran Hallmans, R. Palmqvist, Domenico Palli, Rosario Tumino, Sabina Rinaldi, Manuela M. Bergmann, Franco Berrino, Magritt Brustad, Eva Ardanaz, Heiner Boeing, Miren Dorronsoro, Nadia Slimani, Françoise Clavel-Chapelon, Petra H.M. Peeters, Elio Riboli, Mazda Jenab, Laudina Rodríguez, Marie-Christine Boutron-Ruault, Carlos A. González, [Jenab M, Ferrari P, Slimani N, Byrnes G, Rinaldi S, Autier P, Hainaut P] International Agency for Research on Cancer (IARC-WHO), Lyon, France. [Bueno-de-Mesquita HB, van Duijnhoven FJB, Jansen EHJM, Ros MM] National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands. [Ferrari P] Data Collection and Exposure Unit, European Food Safety Authority (EFSA), Parma, Italy. [van Duijnhoven FJB, van Gils CH, Peeters PH] Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht, Netherlands. [Norat T, Vineis P, Riboli E] School of Public Health, Imperial College, London, UK. [Pischon T, Boeing H, Bergmann MM] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. [Tjonneland A, Olsen A] Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. [Overvad K] Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark. [Boutron-Ruault M-C, Clavel-Chapelon F, Morois S] Inserm (Institut National de la Santé et de la Recherche Médicale) ERI 20, EA. [Kaaks R, Linseisen J] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Trichopoulou A, Misirli G] Department of Hygiene and Epidemiology, University of Athens Medical School, Greece. [Trichopoulou A] Hellenic Health Foundation, Greece. [Trichopoulos D] Department of Epidemiology, Harvard School of Public Health, USA and Bureau of Epidemiologic Research, Academy of Athens, Greece. [Berrino F] Department of Preventive and Predictive Medicine, Etiologic Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori (National Cancer Institute), Milan, Italy. [Vineis P] ISI Foundation, Turin, Italy. [Panico S] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Palli D] Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), Florence, Italy. [Tumino R] Ragusa Cancer Registry and Histopathology Unit, 'Civile M.P.Arezzo' Hospital, ASP 7 Ragusa, Italy. [Ros MM] Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. [Brustad M, Lund E] Centre for Sami Health Research, Institute of Community Medicine, University of Tromsø, Tromsø, Norway. [Tormo MJ] Epidemiology Service, Murcia Regional Health Authority, Spain. [Ardanaz E] Public Health Institute of Navarra, Pamplona, Spain. [Ardanaz E, Sánchez MJ] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Rodríguez L] Health Information Section, Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain. [Sánchez MJ] Andalusian School of Public Health-Granada (Spain). [Dorronsoro M] Epidemiology Unit, Public Health Division of Guipuzkoa, San Sebastian, Spain. [Gonzalez CA] Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. [Hallmans G] Department of Public Health and Clinical Medicine, Nutritional Research, Umeå, Sweden. [Palmqvist R] Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden. [Roddam A, Key TJ] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. [Khaw KT] Clinical Gerontology Unit, University of Cambridge, Cambridge, UK. [Bueno-de-Mesquita HB] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands. [Linseisen J] Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, We thank the World Cancer Research Fund (WCRF, London, UK, grant number 2005/12) for grant funding for the present study. The EPIC study was supported by the Europe Against Cancer Programme of the European Commission (SANCO), Ligue contre le Cancer (France), Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM), German Cancer Aid, German Cancer Research Center, German Federal Ministry of Education and Research, Danish Cancer Society, Health Research Fund (FIS) of the Spanish Ministry of Health (RETIC-RD06/0020), the participating regional governments and institutions of Spain, The ISCIII Red de Centro RCESP (C03/09), Cancer Research UK, Medical Research Council, UK, the Stroke Association, UK, British Heart Foundation, Department of Health, UK, Food Standards Agency, UK, the Wellcome Trust, UK, Greek Ministry of Health and Social Solidarity, Hellenic Health Foundation and Stavros Niarchos Foundation, Greek Ministry of Education, Italian Association for Research on Cancer, Italian National Research Council, Compagnia di San Paolo, Dutch Ministry of Public Health, Welfare and Sports, Dutch Ministry of Health, Dutch Prevention Funds, LK Research Funds, Dutch ZON (Zorg Onderzoek Nederland), Swedish Cancer Society, Swedish Scientific Council, Regional Governments of Skane and Vasterbotten, Sweden, and Norwegian Cancer Society., Jenab, M, Bueno de Mesquita, Hb, Ferrari, P, van Duijnhoven, Fj, Norat, T, Pischon, T, Jansen, Eh, Slimani, N, Byrnes, G, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Boutron Ruault, Mc, Clavel Chapelon, F, Morois, S, Kaaks, R, Linseisen, J, Boeing, H, Bergmann, Mm, Trichopoulou, A, Misirli, G, Trichopoulos, D, Berrino, F, Vineis, P, Panico, Salvatore, Palli, D, Tumino, R, Ros, Mm, van Gils, Ch, Peeters, Ph, Brustad, M, Lund, E, Tormo, Mj, Ardanaz, E, Rodríguez, L, Sánchez, Mj, Dorronsoro, M, Gonzalez, Ca, Hallmans, G, Palmqvist, R, Roddam, A, Key, Tj, Khaw, Kt, Autier, P, Hainaut, P, Riboli, E., and University of Groningen
Subjects: Oncology, Male, Colorectal cancer, 0302 clinical medicine, Risk Factors, Neoplasias colorrectales, SERUM 25-HYDROXYVITAMIN-D, DIETARY-INTAKE, Epidemiology, 030212 general & internal medicine, Vitamin D, General Environmental Science, 2. Zero hunger, Colon Cancer, COLON-CANCER, Confounding, General Engineering, Estudios de Casos y Controles, Geographicals::Geographic Locations::Europe [Medical Subject Headings], General Medicine, Middle Aged, META-ANALYSIS, 3. Good health, Europe, 030220 oncology & carcinogenesis, Cohort, Female, Risk assessment, Colorectal Neoplasms, Europa, Life Sciences & Biomedicine, D SUPPLEMENTATION, medicine.medical_specialty, CALCIUM INTAKE, Vitamina D, Chemicals and Drugs::Polycyclic Compounds::Steroids::Secosteroids::Vitamin D [Medical Subject Headings], Enzyme-Linked Immunosorbent Assay, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings], Medicine, General & Internal, D-RECEPTOR, General & Internal Medicine, Internal medicine, Vitamin D and neurology, medicine, Humans, ddc:610, Life Style, Immunology (Including Allergy), Science & Technology, Dose-Response Relationship, Drug, 25-HYDROXYVITAMIN-D LEVELS, business.industry, Research, Case-control study, Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [Medical Subject Headings], medicine.disease, RANDOMIZED-CONTROLLED-TRIALS, Diet, Epidemiologic Studies, Endocrinology, Cardiovascular and Metabolic Diseases, Case-Control Studies, Nested case-control study, General Earth and Planetary Sciences, Calcium, D METABOLITES, business
Abstract: Contains fulltext : 88351.pdf (Publisher’s version ) (Open Access) OBJECTIVE: To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. DESIGN: Nested case-control study. Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries. PARTICIPANTS: 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls MAIN OUTCOME MEASURES: Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders. RESULTS: 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend or=100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P
Published: 2010

13. Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

Author: Yvoni Koumantaki, Elio Riboli, Bethany Van Guelpen, Nicholas J. Wareham, Paolo Vineis, Birgit Hoeft, Karin Jirström, Elizabeth A Spencer, Jonas Manjer, Göran Hallmans, H. B. Bueno-De-Mesquita, Ulla Vogel, Veronique Chajes, Carla H. van Gils, Paolo Boffetta, Heiner Boeing, Lars Beckmann, Kim Overvad, Rikke Dalgaard Hansen, Marianne Uhre Jakobsen, Laudina Rodríguez, Franco Berrino, Eiliv Lund, Mazda Jenab, Petra H.M. Peeters, Sophie Morois, Traci Mouw, Jakob Linseisen, Teresa Norat, Aurelio Barricarte, F. Clavel-Chapelon, Karin Müller-Decker, Fränzel J.B. Van Duijnhoven, Francesca L. Crowe, José María Huerta Castaño, Dimitrios Trichopoulos, Antonia Trichopoulou, Sven Knüppel, Rudolf Kaaks, Federico Canzian, Domenico Palli, Vanessa Dumeaux, Alexandra Nieters, Kay-Tee Khaw, Anika Hüsing, Xavier Muñoz, Rosario Tumino, Marie-Christine Boutron-Ruault, Salvatore Panico, Hoeft, B, Linseisen, J, Beckmann, L, Müller Decker, K, Canzian, F, Hüsing, A, Kaaksr, Vogel, U, Jakobsen, Mu, Overvad, K, Hansen, Rd, Knüppel, S, Boeing, H, Trichopoulou, A, Koumantaki, Y, Trichopoulos, D, Berrino, F, Palli, D, Panico, Salvatore, Tumino, R, Bueno de Mesquita, Hb, van Duijnhoven, Fj, van Gils, Ch, Peeters, Ph, Dumeaux, V, Lunde, Huerta Castaño, Jm, Muñoz, X, Rodriguez, L, Barricarte, A, Manjer, J, Jirström, K, Van Guelpen, B, Hallmans, G, Spencer, Ea, Crowe, Fl, Khaw, Kt, Wareham, N, Morois, S, Boutron Ruault, Mc, Clavel Chapelon, F, Chajes, V, Jenab, M, Boffetta, P, Vineis, P, Mouw, T, Norat, T, Riboli, E, Nieters, A., Hoeft, B., Linseisen, J., Beckmann, L., Müller-Decker, K., Canzian, F., Hüsing, A., Kaaks, R., Vogel, U., Jakobsen, M.U., Overvad, K., Hansen, R.D., Knüppel, S., Boeing, H., Trichopoulou, A., Koumantaki, Y., Trichopoulos, D., Berrino, F., Palli, D., Panico, S., Tumino, R., Buenode-Mesquita, H.B., van Duijnhoven, F.J.B., van Gils, C.H., Peeters, P.H., Dumeaux, V., Lund, E., Huerta Castaño, J.M., Muñoz, X., Rodriguez, L., Barricarte, A., Manjer, J., Jirström, K., van Guelpen, B., Hallmans, G., Spencer, E.A., Crowe, F.L., Khaw, K.-T., Wareham, N., Morois, S., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Chajes, V., Jenab, M., Boffetta, P., Vineis, P., Mouw, T., Norat, T., and Riboli, E.
Subjects: Oncology, Male, Cancer Research, Colorectal cancer, Cohort Studies, 0302 clinical medicine, Genetics, 0303 health sciences, Group III Phospholipases A2, Fatty Acids, Smoking, General Medicine, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Neoplasm Proteins, Europe, 030220 oncology & carcinogenesis, Hydroxyprostaglandin Dehydrogenases, Female, Colorectal Neoplasms, medicine.medical_specialty, Genotype, TRPV Cation Channels, colorectal cancer, Single-nucleotide polymorphism, Biology, Adenocarcinoma, Polymorphism, Single Nucleotide, Group VI Phospholipases A2, 03 medical and health sciences, Internal medicine, medicine, Humans, Receptors, Prostaglandin E, ddc:610, Polymorphism, Allele frequency, Alleles, Genetic Association Studies, 030304 developmental biology, Haplotype, Cancer, Odds ratio, Receptors, Prostaglandin E, EP2 Subtype, medicine.disease, Minor allele frequency, Haplotypes, Case-Control Studies, fatty acid, metabolism
Abstract: Colorectal cancer (CRC) is the third most common malignant tumor and the fourth leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in-depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r2 cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whereas prostaglandin E receptor 2 (PTGER2) was associated with lower CRC risk. A significant inverse association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P = 0.003, respectively) associated with higher risk of CRC. Based on these data, we present for the first time the association of HPGD variants with CRC risk. Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk. © The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.
Published: 2010

14. Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Françoise Clavel-Chapelon, Sophie Morois, Carla H. van Gils, Miren Dorronsoro, Nadia Slimani, Paolo Boffetta, Rudolf Kaaks, Aurelio Barricarte, Magritt Brustad, Laudina Rodríguez, Frederike L. Büchner, Sabina Sieri, Naomi E. Allen, Dagrun Engeset, Elio Riboli, Kim Overvad, Sheila Bingham, Göran Hallmans, Carlos González, Heiner Boeing, Eiliv Lund, Antonia Trichopoulou, Dimitrios Trichopoulos, Emily Sonestedt, Ingegerd Johansson, Janine Wichmann, Pagona Lagiou, Mazda Jenab, José María Huerta, Anne Tjønneland, H. Bas Bueno-de-Mesquita, Traci Mouw, Jakob Linseisen, Teresa Norat, Jonas Manjer, Michael Nielsen, Petra H.M. Peeters, Vassiliki Benetou, Fränzel J.B. Van Duijnhoven, Anja Olsen, Elisabeth Couto, Pietro Ferrari, Timothy J. Key, Domenico Palli, Marie-Christine Boutron-Ruault, Salvatore Panico, Ute Nöthlings, Kay-Tee Khaw, Androniki Naska, Paolo Vineis, María José Sánchez, Sabine Rohrmann, 33: Boffetta, P, Couto, E, Wichmann, J, Ferrari, P, Trichopoulos, D, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Büchner, Fl, Key, T, Boeing, H, Nöthlings, U, Linseisen, J, Gonzalez, Ca, Overvad, K, Nielsen, Mr, Tjønneland, A, Olsen, A, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Lagiou, P, Naska, A, Benetou, V, Kaaks, R, Rohrmann, S, Panico, Salvatore, Sieri, S, Vineis, P, Palli, D, van Gils, Ch, Peeters, Ph, Lund, E, Brustad, M, Engeset, D, Huerta, Jm, Rodríguez, L, Sánchez, Mj, Dorronsoro, M, Barricarte, A, Hallmans, G, Ohansson, I, Manjer, J, Sonestedt, E, Allen, Ne, Bingham, S, Khaw, Kt, Slimani, N, Jenab, M, Mouw, T, Norat, T, Riboli, E, Trichopoulou, A., Boffetta, P., Couto, E., Wichmann, J., Ferrari, P., Trichopoulos, D., Bueno-De-Mesquita, H.B., Van Duijnhoven, F.J.B., Büchner, F.L., Key, T., Boeing, H., Nöthlings, U., Linseisen, J., Gonzalez, C.A., Overvad, K., Nielsen, M.R.S., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Lagiou, P., Naska, A., Benetou, V., Kaaks, R., Rohrmann, S., Panico, S., Sieri, S., Vineis, P., Palli, D., Van Gils, C.H., Peeters, P.H., Lund, E., Brustad, M., Engeset, D., Huerta, J.M., Rodríguez, L., Sánchez, M.-J., Dorronsoro, M., Barricarte, A., Hallmans, G., Johansson, I., Manjer, J., Sonestedt, E., Allen, N.E., Bingham, S., Khaw, K.-T., Slimani, N., Jenab, M., Mouw, T., Norat, T., and Riboli, E.
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Alcohol Drinking, tobacco, Risk Assessment, smoking, Molecular epidemiology [NCEBP 1], nutrition in cancer, Risk Factors, Neoplasms, Surveys and Questionnaires, Environmental health, Vegetables, Epidemiology, follow-up, Odds Ratio, cancer, vegetable, Humans, Medicine, Prospective Studies, Registries, Food science, ddc:610, Prospective cohort study, Life Style, risk, Aged, Observer Variation, Proportional hazards model, business.industry, Incidence, Hazard ratio, Feeding Behavior, Odds ratio, Middle Aged, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Research Design, Fruit, Cohort, Female, diet, Risk assessment, business
Abstract: Contains fulltext : 88546.pdf (Publisher’s version ) (Closed access) BACKGROUND: It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit and vegetable intake and overall cancer risk. METHODS: We conducted a prospective analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to assess relationships between intake of total fruits, total vegetables, and total fruits and vegetables combined and cancer risk during 1992-2000. Detailed information on the dietary habit and lifestyle variables of the cohort was obtained. Cancer incidence and mortality data were ascertained, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox regression models. Analyses were also conducted for cancers associated with tobacco and alcohol after stratification for tobacco smoking and alcohol drinking. RESULTS: Of the initial 142 605 men and 335 873 women included in the study, 9604 men and 21 000 women were identified with cancer after a median follow-up of 8.7 years. The crude cancer incidence rates were 7.9 per 1000 person-years in men and 7.1 per 1000 person-years in women. Associations between reduced cancer risk and increased intake of total fruits and vegetables combined and total vegetables for the entire cohort were similar (200 g/d increased intake of fruits and vegetables combined, HR = 0.97, 95% CI = 0.96 to 0.99; 100 g/d increased intake of total vegetables, HR = 0.98, 95% CI = 0.97 to 0.99); intake of fruits showed a weaker inverse association (100 g/d increased intake of total fruits, HR = 0.99, 95% CI = 0.98 to 1.00). The reduced risk of cancer associated with high vegetable intake was restricted to women (HR = 0.98, 95% CI = 0.97 to 0.99). Stratification by alcohol intake suggested a stronger reduction in risk in heavy drinkers and was confined to cancers caused by smoking and alcohol. CONCLUSIONS: A very small inverse association between intake of total fruits and vegetables and cancer risk was observed in this study. Given the small magnitude of the observed associations, caution should be applied in their interpretation.
Published: 2010

15. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition

Author: Petra H.M. Peeters, Domenico Palli, Carmen Navarro, Carla H. van Gils, Jonas Manjer, Corinne Casagrande, Mazda Jenab, Jakob Linseisen, Ute Nöthlings, Paolo Vineis, Martine M. Ros, Sheila Bingham, Anja Olsen, Miren Dorronsoro, Elio Riboli, Göran Berglund, Pietro Ferrari, Aurelio Barricarte, Nadia Slimani, Antonia Trichopoulou, Marie-Christine Boutron-Ruault, Dagrun Engeset, Salvatore Panico, Marga C. Ocké, Françoise Clavel-Chapelon, Sabina Sieri, Ole Thorlacius-Ussing, Dimitrios Trichopoulos, Sophie Morois, Timothy J. Key, Kim Overvad, Valentina Gallo, Carlos A. González, Rosario Tumino, Paolo Boffetta, Heiner Boeing, H. Bas Bueno-de-Mesquita, Kay-Tee Khaw, Anne Tjønneland, Teresa Norat, Laudina Rodríguez Suárez, Fränzel J. B. van Duijnhoven, Guri Skeie, Naomi E. Allen, Eiliv Lund, Rudolf Kaaks, Richard Palmqvist, Gesthimani Misirli, María José Sánchez, Göran Hallmans, Hendriek C. Boshuizen, Sabina Rinaldi, Van Duijnhoven, F.J.B., Bueno-De-Mesquita, H.B., Ferrari, P., Jenab, M., Boshuizen, H.C., Ros, M.M., Casagrande, C., Tjønneland, A., Olsen, A., Overvad, K., Thorlacius-Ussing, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Kaaks, R., Linseisen, J., Boeing, H., Nöthlings, U., Trichopoulou, A., Trichopoulos, D., Misirli, G., Palli, D., Sieri, S., Panico, S., Tumino, R., Vineis, P., Peeters, P.H.M., Van Gils, C.H., Ocké, M.C., Lund, E., Engeset, D., Skeie, G., Suárez, L.R., González, C.A., Sánchez, M.-J., Dorronsoro, M., Navarro, C., Barricarte, A., Berglund, G., Manjer, J., Hallmans, G., Palmqvist, R., Bingham, S.A., Khaw, K.-T., Key, T.J., Allen, N.E., Boffetta, P., Slimani, N., Rinaldi, S., Gallo, V., Norat, T., Riboli, E., van Duijnhoven, Fj, Bueno De Mesquita, Hb, Ferrari, P, Jenab, M, Boshuizen, Hc, Ros, Mm, Casagrande, C, Tjønneland, A, Olsen, A, Overvad, K, Thorlacius Ussing, O, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Trichopoulos, D, Misirli, G, Palli, D, Sieri, S, Panico, Salvatore, Tumino, R, Vineis, P, Peeters, Ph, van Gils, Ch, Ocké, Mc, Lund, E, Engeset, D, Skeie, G, Suárez, Lr, González, Ca, Sánchez, Mj, Dorronsoro, M, Navarro, C, Barricarte, A, Berglund, G, Manjer, J, Hallmans, G, Palmqvist, R, Bingham, Sa, Khaw, Kt, Key, Tj, Allen, Ne, Boffetta, P, Slimani, N, Rinaldi, S, Gallo, V, and Norat, T
Subjects: Questionnaires, Oncology, Male, medicine.medical_specialty, Time Factors, Colorectal cancer, Medicine (miscellaneous), Environment, Gastroenterology, 03 medical and health sciences, Fruit vegetables colorectal cancer risk The European Prospective Investigation Cancer Nutrition, 0302 clinical medicine, Risk Factors, Internal medicine, Surveys and Questionnaires, Vegetables, medicine, Humans, ddc:610, Prospective Studies, Risk factor, Life Style, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, Proportional hazards model, business.industry, Incidence (epidemiology), Incidence, Patient Selection, Hazard ratio, Smoking, Cancer, Reproducibility of Results, Colonoscopy, medicine.disease, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Diet, Europe, 030220 oncology & carcinogenesis, Fruit, Cohort, Female, business, Colorectal Neoplasms, Demography, Follow-Up Studies
Abstract: Background: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. Objective: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. Design: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs. Results: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction < 0.01 for both). Conclusions: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status. © 2009 American Society for Nutrition.
Published: 2009

16. Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Anette Hjartåker, Rudolf Kaaks, Björn Lindkvist, Larraitz Arriola, Albert B. Lowenfels, Guy Fagherazzi, Heiner Boeing, Weimin Ye, Kay-Tee Khaw, H. Bas Bueno-de-Mesquita, Nadia Slimani, Traci Mouw, Françoise Clavel-Chapelon, Salvatore Panico, Eric J. Duell, Paolo Boffetta, Jonas Manjer, Majken K. Jensen, Jakob Linseisen, Aurelio Barricarte Gurrea, Andrew W. Roddam, Petra H.M. Peeters, Antonio Agudo, Alina Vrieling, Dominique S. Michaud, Gesthimani Misirli, Ingegerd Johansson, Naomi E. Allen, Eiliv Lund, Domenico Palli, Marie-Christine Boutron-Ruault, Manuela M. Bergmann, Anja Olsen, Rachael Z. Stolzenberg-Solomon, Sheila Bingham, Antonia Trichopoulou, Sabine Rohrmann, Anne Tjønneland, María José Sánchez, Pagona Lagiou, Rosario Tumino, Paolo Vineis, María José Tormo, Ma Luisa Redondo Cornejo, Kim Overvad, Elio Riboli, Valeria Pala, Mazda Jenab, Rohrmann, S, Linseisen, J, Vrieling, A, Boffetta, P, Stolzenberg Solomon, Rz, Lowenfels, Ab, Jensen, Mk, Overvad, K, Olsen, A, Tjonneland, A, Boutron Ruault, Mc, Clavel Chapelon, F, Fagherazzi, G, Misirli, G, Lagiou, P, Trichopoulou, A, Kaaks, R, Bergmann, Mm, Boeing, H, Bingham, S, Khaw, Kt, Allen, N, Roddam, A, Palli, D, Pala, V, Panico, Salvatore, Tumino, R, Vineis, P, Peeters, Ph, Hjartåker, A, Lund, E, Redondo Cornejo, Ml, Agudo, A, Arriola, L, Sánchez, Mj, Tormo, Mj, Barricarte Gurrea, A, Lindkvist, B, Manjer, J, Johansson, I, Ye, W, Slimani, N, Duell, Ej, Jenab, M, Michaud, D, Mouw, T, Riboli, E, Bueno de Mesquita, Hb, Rohrmann, S., Linseisen, J., Vrieling, A., Boffetta, P., Stolzenberg-Solomon, R.Z., Lowenfels, A.B., Jensen, M.K., Overvad, K., Olsen, A., Tjonneland, A., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Fagherazzi, G., Misirli, G., Lagiou, P., Trichopoulou, A., Kaaks, R., Bergmann, M.M., Boeing, H., Bingham, S., Khaw, K.-T., Allen, N., Roddam, A., Palli, D., Pala, V., Panico, S., Tumino, R., Vineis, P., Peeters, P.H.M., Hjartåker, A., Lund, E., Cornejo, M.L.R., Agudo, A., Arriola, L., Sánchez, M.-J., Tormo, M.-J., Barricarte Gurrea, A., Lindkvist, B., Manjer, J., Johansson, I., Ye, W., Slimani, N., Duell, E.J., Jenab, M., Michaud, D.S., Mouw, T., Riboli, E., and Bueno-De-Mesquita, H.B.
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Alcohol Drinking, EPIC, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pancreatic cancer, Internal medicine, Epidemiology, medicine, Humans, ddc:610, 030212 general & internal medicine, Proportional Hazards Models, business.industry, Cancer, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Surgery, Pancreatic Neoplasms, medicine.anatomical_structure, Ethanol, pancreatic cancer, epidemiology, EPIC, 030220 oncology & carcinogenesis, Female, Ethanol intake, Risk assessment, business, Pancreas, Follow-Up Studies
Abstract: Objective: To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Results: Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. Conclusion: These results suggest no association of alcohol consumption with the risk of pancreatic cancer. © 2009 Springer Science+Business Media B.V.
Published: 2009

17. The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence

Author: Elisabet Wirfält, Salvatore Panico, Jonas Manjer, Jakob Linseisen, Kay-Tee Khaw, Sheila Bingham, Rosario Tumino, María José Tormo, Petra H.M. Peeters, H. Bas Bueno-de-Mesquita, Naomi E. Allen, Anne Tjønneland, Torgny Rasmuson, Antonia Trichopoulou, Gwenn Menvielle, Pietro Ferrari, Nadia Slimani, Paolo Boffetta, Valentina Gallo, Ole Raaschou-Nielsen, Domenico Palli, Timothy J. Key, Elio Riboli, Hendriek Boshuizen, Antonio Agudo, Anton E. Kunst, Susanne Oksbjerg Dalton, Eric J. Duell, Paolo Vineis, Tonje Braaten, Silke Hermann, Maria Kosti, Carla H. van Gils, Vardis Dilis, Göran Hallmans, Eva Ardanaz, Manuela M. Bergmann, María José Sánchez, Inger T. Gram, Vittorio Krogh, Eiliv Lund, Laudina Rodríguez, Frederike L. Büchner, Rudolf Kaaks, Kaniewski, Nadine, Department of Public Health, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Institute of Cancer Epidemiology, Danish Cancer Society, University of Torino and CPO-Piemonte, Università degli studi di Torino = University of Turin (UNITO), Department of Epidemiology, German Institute of Human Nutrition, Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology, Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Department of Preventive & Predictive Medicine, Italian National Center Institute, Department of Clinical and Experimental Medicine, Frederico II University, Cancer Registry Azienda, Civile - M.P.Arezzo Hospital, Julius Center for Health Sciences and Primary Care, VU University Medical Center [Amsterdam], Institute of Community Medicine, University of Tromsø (UiT), Public Health Directorate, Unit of Nutrition, Environment and Cancer, Andalusian School of Public Health [Granada], CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Health Council, Public Health Institute of Navarra, Department of surgery, Lund University [Lund]-Malmö University Hospital, Department of Clinical Sciences, Nutrition Epidemiology, Lund University [Lund], Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Department of Radiation Sciences, Oncology, MRC Centrer for Nutritional Epidemiology and Cancer Prevention and Survival, University of Cambridge [UK] (CAM), Cancer Epidemiology Unit, University of Oxford, Departement of Epidemiolgy and Public Health, Imperial College London, Menvielle, G, Boshuizen, H, Kunst, Ae, Dalton, So, Vineis, P, Bergmann, Mm, Hermann, S, Ferrari, P, Raaschou Nielsen, O, Tjønneland, A, Kaaks, R, Linseisen, J, Kosti, M, Trichopoulou, A, Dilis, V, Palli, D, Krogh, V, Panico, Salvatore, Tumino, R, Büchner, Fl, van Gils, Ch, Peeters, Ph, Braaten, T, Gram, It, Lund, E, Rodriguez, L, Agudo, A, Sánchez, Mj, Tormo, Mj, Ardanaz, E, Manjer, J, Wirfält, E, Hallmans, G, Rasmuson, T, Bingham, S, Khaw, Kt, Allen, N, Key, T, Boffetta, P, Duell, Ej, Slimani, N, Gallo, V, Riboli, E, Bueno de Mesquita, Hb, Public and occupational health, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli studi di Torino (UNITO), University of Oxford [Oxford], Malmö University Hospital-Lund University [Lund], Public Health, Cell biology, Menvielle, G., Boshuizen, H., Kunst, A.E., Dalton, S.O., Vineis, P., Bergmann, M.M., Hermann, S., Ferrari, P., Raaschou-Nielsen, O., Tjønneland, A., Kaaks, R., Linseisen, J., Kosti, M., Trichopoulou, A., Dilis, V., Palli, D., Krogh, V., Panico, S., Tumino, R., Büchner, F.L., Van Gils, C.H., Peeters, P.H.M., Braaten, T., Gram, I.T., Lund, E., Rodriguez, L., Agudo, A., Sánchez, M.-J., Tormo, M.-J., Ardanaz, E., Manjer, J., Wirfält, E., Hallmans, G., Rasmuson, T., Bingham, S., Khaw, K.-T., Allen, N., Key, T., Boffetta, P., Duell, E.J., Slimani, N., Gallo, V., Riboli, E., and Bueno-De-Mesquita, H.B.
Subjects: Male, Cancer Research, Lung Neoplasms, Aetiology, screening and detection [ONCOL 5], 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Vegetables, Odds Ratio, Prospective Studies, 030212 general & internal medicine, 10. No inequality, Prospective cohort study, education, Mediterranean Region, Incidence, Incidence (epidemiology), 1. No poverty, Confounding Factors, Epidemiologic, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Research Design, 030220 oncology & carcinogenesis, Cohort, Educational Status, lung cancer incidence, Female, women, Cohort study, Adult, medicine.medical_specialty, men, Risk Assessment, Article, smoking, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Sex Factors, SDG 3 - Good Health and Well-being, medicine, cohort study, Humans, ddc:610, Sex Distribution, Risk factor, Lung cancer, Socioeconomic status, Aged, Proportional Hazards Models, business.industry, Feeding Behavior, medicine.disease, Social Mobility, Surgery, Social Class, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Fruit, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, EPIC, diet, Demography
Abstract: Background: Studies in many countries have reported higher lung cancer incidence and mortality in individuals with lower socioeconomic status. Methods: To investigate the role of smoking in these inequalities, we used data from 391 251 participants in the European Prospective Investigation into Cancer and Nutrition study, a cohort of individuals in 10 European countries. We collected information on smoking (history and quantity), fruit and vegetable consumption, and education through questionnaires at study entry and gathered data on lung cancer incidence for a mean of 8.4 years. Socioeconomic status was defined as the highest attained level of education, and participants were grouped by sex and region of residence (Northern Europe, Germany, or Southern Europe). Relative indices of inequality (RIIs) of lung cancer risk unadjusted and adjusted for smoking were estimated using Cox regression models. Additional analyses were performed by histological type. Results: During the study period, 939 men and 692 women developed lung cancer. Inequalities in lung cancer risk (RII men = 3.62, 95% confidence interval [CI] = 2.77 to 4.73, 117 vs 52 per 100 000 person-years for lowest vs highest education level; RII women = 2.39, 95% CI = 1.77 to 3.21, 46 vs 25 per 100 000 person-years) decreased after adjustment for smoking but remained statistically significant (RIImen = 2.29, 95% CI = 1.75 to 3.01; RII women = 1.59, 95% CI = 1.18 to 2.13). Large RIIs were observed among men and women in Northern European countries and among men in Germany, but inequalities in lung cancer risk were reverse (RIIs < 1) among women in Southern European countries. Inequalities differed by histological type. Adjustment for smoking reduced inequalities similarly for all histological types and among men and women in all regions. In all analysis, further adjustment for fruit and vegetable consumption did not change the estimates. Conclusion: Self-reported smoking consistently explains approximately 50% of the inequalities in lung cancer risk due to differences in education. © The Author 2009. Published by Oxford University Press. All rights reserved.
Published: 2009

18. Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study

Author: Carmen Martinez, Petra H.M. Peeters, Merethe Kumle, Paolo Vineis, Armelle Munnia, Seymour Garte, Bas Bueno-de-Mesquita, Emmanuelle Gormally, Ole Raaschou-Nielsen, Antonio Agudo, Giuseppe Matullo, Bengt Järvholm, Françoise Clavel-Chapelon, José Ramón Quirós, Göran Berglund, Marco Peluso, Alison M. Dunning, Rosario Tumino, Alessandro Colombi, Salvatore Panico, Timothy J. Key, Luisa Airoldi, Elio Riboli, S Bingham, Fabrizio Veglia, Rudolf Kaaks, Antonia Trichopoulou, Aurelio Barricarte, Vittorio Krogh, Christian Malaveille, Nicholas E. Day, Kim Overvad, Rodolfo Saracci, Herman Autrup, María José Tormo, Domenico Palli, J. Linseisen, Heiner Boeing, Miren Dorronsoro, Faculteit Medische Wetenschappen/UMCG, Peluso, M, Airoldi, L, Munnia, A, Colombi, A, Veglia, F, Autrup, H, Dunning, A, Garte, S, Gormally, E, Malaveille, C, Matullo, G, Overvad, K, Raaschou Nielsen, O, Clavel Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, Salvatore, Bueno De Mesquita, Bh, Peeters, Ph, Kumle, M, Agudo, A, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, Mj, Quiros, Jr, Berglund, G, Jarvholm, B, Day, Ne, Key, Tj, Saracci, R, Kaaks, R, Riboli, E, Bingham, S, Vineis, P., [Peluso,M, Munnia, A] Cancer Risk Factor Branch, Analytical and Biomolecular Cytology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy. [Airoldi,L, Colombi,A] Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. [Veglia, F, Matullo,G] ISI Foundation, Turin, Italy. [Autrup,H] Department of Environmental and Occupational Medicine, Aarhus, Denmark. [Dunning, A] Department of Oncology, University of Cambridge, Cambridge, UK. [Garte,S] Genetics Research Institute, Milan, Italy. [Gormally,E, Malaveille,C] International Agency for Research on Cancer, Lyon, France. [Overhad,K] Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. [Raaschou-Nielsen,O] Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. [Clavel-Chapelon,F] INSERM (Institut National de la Sante´ et de la Recherche Me´dicale), ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, F-94805, France. [Linseisen,J] Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, German. [Boeing,H] German Institute of Human Nutrition, Potsdam-Rehbu¨cke, Germany. [Trichopoulou,A] Department of Hygiene and Epidemiology, Medical School, University of Athens, Athens, Greece. [Palli,D] Molecular and Nutritional Epidemiology Unit, CSPO-Scientiﬁc Institute of Cancer Prevention Tuscany Region, Florence, Italy. [Krogh,V] Department of Epidemiology, National Cancer Institute, Milan, Italy. [Tumino,R] Cancer Registry, Azienda Ospedaliera ‘Civile MP Arezzo’, Ragusa, Ital. [Panico,S] Dipartimento di Medicina Clinica e Sperimentale, Universita` Federico II, Naples, Italy. [Bueno-De-Mesquita,BH] Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherland. [Peeters,PH] Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands. [Kumle,M] Institute of Community Medicine, University of Tromso, Tromso, Norway. [Agudo,A] Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain. [Martinez,C] Andalusian School of Public Health, Granada, Spain. [Dorronsoro,M] Department of Public Health of Guipuzkoa, San Sebastian, Spain. [Barricarte,A] Public Health Institute, Navarra, Spain. [Tormo,MJ] Epidemiology Department, Murcia Health Council, Murcia, Spain. Quiros, JR] Direccio´n General de Salud Pu´blica, Consejerı´a de Salud y Servicios Sanitarios Asturias, Oviedo, Spain. [Berglund,G] Malmo¨ Diet and Cancer Study, Lund University, Malmo¨, Sweden. [Jarvholm,G] Department of Nutritional Research, University of Umea˚, Umea˚ , Sweden. [Day,ND, Bingham,S] MRC Dunn Human Nutrition Unit, Cambridge University, UK. [Key,TJ].Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK. [Saracci,R] IFC National Research Council, Pisa, Italy. [Kaas,R] Division of Epidemiology, DKFZ Heidelberg, Germany. [Riboli,E] Imperial College London, London, UK. [Vineis,P] University of Turin, Turin, Italy. Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK, This paper was made possible by a grant of the European Community (5th Framework Programme) to P. V. (grant QLK4–CT–1999–00 927) and a grant of the Compagnia di San Paolo to the ISI Foundation. All authors are independent from funders. Mortality data for the Netherlands were obtained from Statistics Netherlands. Also, the work described in the paper was carried out with the financial support of: Europe Against Cancer Program of the European Commission (SANCO), ISCIII, Red de Centros RCESP, C03/09, Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research, Danish Cancer Society, Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, Cancer Research UK, Medical Research Council, UK, Stroke Association, UK, British Heart Foundation, Department of Health, UK, Food Standards Agency, UK, Wellcome Trust, UK, Greek Ministry of Health, Greek Ministry of Education, Italian Association for Research on Cancer (AIRC), Italian National Research Council, Dutch Ministry of Public Health, Welfare and Sports, World Cancer Research Fund, Swedish Cancer Society, Swedish Scientific Council, Regional Government of Ska°ne, Sweden, Norwegian Cancer Society, and Research Council of Norway.
Subjects: Dietary Fiber, Male, Aflatoxin, Erythrocytes, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Hemoglobins [Medical Subject Headings], medicine.medical_treatment, air pollution, RESISTANT STARCH, Medicine (miscellaneous), GUIDELINES, Carcinógenos, Body Mass Index, COLORECTAL-CANCER, Food group, chemistry.chemical_compound, Hemoglobins, Vegetables, Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Air Pollutants [Medical Subject Headings], Leukocytes, Aductos de ADN, Nutritional Physiological Phenomena, Food science, Prospective Studies, RISK, DNA adducts, Haemoglobin adducts, Non-smokers, Fibre intake, Air pollution, Publication Characteristics::Study Characteristics::Multicenter Study [Medical Subject Headings], Air Pollutants, Nutrition and Dietetics, Chemistry, Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Fiber [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Noxae::Carcinogens [Medical Subject Headings], COLON-CANCER, Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage::DNA Adducts [Medical Subject Headings], Fabaceae, Middle Aged, fibre intake, European Prospective Investigation into Cancer and Nutrition, Europe, Biochemistry, 4-Aminobiphenyl, Colonic Neoplasms, Hemoglobinas, Female, SMOKERS, Alcohol Drinking, BLADDER-CANCER, European Prospective Investigation into Cancer and Nutrition (EPIC), haemoglobin adducts, non-smokers, RATS, POLYCYCLIC AROMATIC-HYDROCARBONS, Ozone, LUNG-CANCER, DNA adduct, medicine, Humans, Contaminantes del aire, ddc:610, Carcinogen, Aged, Estudio multicéntrico, Vitamin E, Fruit, Multivariate Analysis, Fibras en la dieta, Carcinogens, Biomarkers, Food contaminant
Abstract: Udgivelsesdato: 2008-Feb-14 In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse, statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P = 0.02), vitamin E (P = 0.04) and alcohol (P = 0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P = 0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances.
Published: 2008

19. Dietary patterns and survival of older Europeans: the EPIC-Elderly Study (European Prospective Investigation into Cancer and Nutrition)

Author: Christina Kasapa, Emmanuelle Kesse, Elisabet Wirfält, Domenico Palli, Salvatore Panico, J. Linseisen, Paolo Boffetta, Pietro Ferrari, Kim Overvad, Carmen Martinez-Garcia, Miren Dorronsoro, Göran Berglund, H. Bas Bueno-de-Mesquita, Nadia Slimani, Aurelio Barricarte, Marie-Christine Boutron-Ruault, Carlotta Sacerdote, Yvonne T. van der Schouw, Chrysoula Travezea, Christina Bamia, Teresa Norat, Elizabeth A Spencer, Sheila Bingham, Timothy J. Key, Françoise Clavel-Chapelon, Jytte Halkjær, Valeria Pala, Anastasia Orfanou, Lone Jeppesen Bjerregaard, Elio Riboli, Antonia Trichopoulou, Patricia M C M Waijers, Petra H.M. Peeters, Dimitrios Trichopoulos, Rosario Tumino, Ingegerd Johansson, Gerd Johansson, Kurt Hoffmann, Gabriele Nagel, Anne Tjønneland, Heiner Boeing, Kay-Tee Khaw, Antonio Berenguer, Carmen Navarro, Bamia, C, Trichopoulos, D, Ferrari, P, Overvad, K, Bjerregaard, L, Tjonneland, A, Halkjaer, J, CLAVEL CHAPELON, F, Kesse, E, BOUTRON RUAULT, Mc, Boffetta, P, Nagel, G, Linseisen, J, Boeing, H, Hoffmann, K, Kasapa, C, Orfanou, A, Travezea, C, Slimani, N, Norat, T, Palli, D, Pala, V, Panico, Salvatore, Tumino, R, Sacerdote, C, BUENO DE MESQUITA, Hb, Waijers, Pm, Peeters, Ph, VAN DER SCHOUW, Yt, Berenguer, A, MARTINEZ GARCIA, C, Navarro, C, Barricarte, A, Dorronsoro, M, Berglund, G, Wirfalt, E, Johansson, I, Johansson, G, Bingham, S, Khaw, Kt, Spencer, Ea, Key, T, Riboli, E, Trichopoulou, A., Bamia, C., Trichopoulos, D., Ferrari, P., Overvad, K., Bjerregaard, L., Tjønneland, A., Halkjær, J., Clavel-Chapelon, F., Kesse, E., Boutron-Ruault, M.C., Boffetta, P., Nagel, G., Linseisen, J., Boeing, H., Hoffmann, K., Kasapa, C., Orfanou, A., Travezea, C., Slimani, N., Norat, T., Palli, D., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H.B., Waijers, P.M.C.M., Peeters, P.H.M., Van Der Schouw, Y.T., Berenguer, A., Martinez-Garcia, C., Navarro, C., Barricarte, A., Dorronsoro, M., Berglund, G., Wirfält, E., Johansson, I., Johansson, G., Bingham, S., Khaw, K.-T., Spencer, E.A., Key, T., and Riboli, E.
Subjects: Gerontology, Male, Mediterranean diet, Population, Longevity, Medicine (miscellaneous), Diet, Mediterranean, Cohort Studies, Cause of Death, Vegetables, Medicine, Humans, Prospective Studies, ddc:610, Prospective cohort study, education, Survival analysis, Aged, Proportional Hazards Models, Dietary patterns survival older EPIC-Elderly Study European Prospective Investigation Cancer Nutrition, Aged, 80 and over, education.field_of_study, Nutrition and Dietetics, business.industry, Proportional hazards model, Public Health, Environmental and Occupational Health, Middle Aged, Survival Analysis, European Prospective Investigation into Cancer and Nutrition, Diet, Europe, Cohort, Female, business, Demography, Cohort study
Abstract: ObjectiveTo investigate the association of a posteriori dietary patterns with overall survival of older Europeans.Design and settingThis is a multi-centre cohort study. Cox regression analysis was used to investigate the association of the prevailing, a posteriori-derived, plant-based dietary pattern with all-cause mortality in a population of subjects who were 60 years or older at recruitment to the European Prospective Investigation into Cancer and Nutrition (EPIC-Elderly cohort). Analyses controlled for all known potential risk factors.SubjectsIn total, 74 607 men and women, 60 years or older at enrolment and without previous coronary heart disease, stroke or cancer, with complete information about dietary intakes and potentially confounding variables, and with known survival status as of December 2003, were included in the analysis.ResultsAn increase in the score which measures the adherence to the plant-based diet was associated with a lower overall mortality, a one standard deviation increment corresponding to a statistically significant reduction of 14% (95% confidence interval 5–23%). In country-specific analyses the apparent association was stronger in Greece, Spain, Denmark and The Netherlands, and absent in the UK and Germany.ConclusionsGreater adherence to the plant-based diet that was defined a posteriori in this population of European elders is associated with lower all-cause mortality. This dietary score is moderately positively correlated with the Modified Mediterranean Diet Score that has been constructed a priori and was also shown to be beneficial for the survival of the same EPIC-Elderly cohort.
Published: 2007

20. Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC)

Author: Salvatore Panico, Marga C. Ocké, H. Bas Bueno-de-Mesquita, Carla H. van Gils, Teresa Norat, Antonio Agudo, Pilar Amiano, Göran Berglund, Mazda Jenab, Eva Ardanaz, Rudolf Kaaks, Jonas Manjer, Pietro Ferrari, Dolores C. López, Jakob Linseisen, Elio Riboli, Françoise Clavel-Chapelon, Sophie Morois, María José Sánchez, Mathieu Mazuir, Heiner Boeing, Rosario Tumino, Majken K. Jensen, Christina Kassapa, Marie-Christine Boutron-Ruault, Petra H.M. Peeters, Eiliv Lund, Paolo Vineis, Kim Overvad, Anja Olsen, Timothy J. Key, Paolo Boffetta, Giovanna Masala, Manuela M. Bergmann, Sabine Rohrmann, Vittorio Krogh, Nadia Slimani, Guri Skeie, Naomi E. Allen, Aurelie Moskal, José Ramón Quirós, Bethany Van Guelpen, Richard Palmqvist, Dimitra Kontopoulou, Anne Tjønneland, Sheila Bingham, Antonia Trichopoulou, Ferrari, P, Jenab, M, Norat, T, Moskal, A, Slimani, N, Olsen, A, Tjonneland, A, Overvad, K, Jensen, Mk, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Morois, S, Rohrmann, S, Linseisen, J, Boeing, H, Bergmann, M, Kontopoulou, D, Trichopoulou, A, Kassapa, C, Masala, G, Krogh, V, Vineis, P, Panico, Salvatore, Tumino, R, Gils, Ch, Peeters, P, BUENO DE MESQUITA, Hb, Ocke, Mc, Skeie, G, Lund, E, Agudo, A, Ardanaz, E, Lopez, Dc, Sanchez, Mj, Quiros, Jr, Amiano, P, Berglund, G, Manjer, J, Palmqvist, R, Guelpen, Bv, Allen, N, Key, T, Bingham, S, Mazuir, M, Boffetta, P, Kaaks, R, Riboli, E., Ferrari, P., Jenab, M., Norat, T., Moskal, A., Slimani, N., Olsen, A., Tjønneland, A., Overvad, K., Jensen, M.K., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Morois, S., Rohrmann, S., Linseisen, J., Boeing, H., Bergmann, M., Kontopoulou, D., Trichopoulou, A., Kassapa, C., Masala, G., Krogh, V., Vineis, P., Panico, S., Tumino, R., Van Gils, C.H., Peeters, P., Bueno-de-Mesquita, H.B., Ocké, M.C., Skeie, G., Lund, E., Agudo, A., Ardanaz, E., López, D.C., Sanchez, M.-J., Quirós, J.R., Amiano, P., Berglund, G., Manjer, J., Palmqvist, R., Van Guelpen, B., Allen, N., Key, T., Bingham, S., Mazuir, M., Boffetta, P., and Kaaks, R.
Subjects: Oncology, Male, Cancer Research, medicine.medical_specialty, Time Factors, Alcohol intake and risk of colon and rectal cancers, Alcohol Drinking, Colorectal cancer, alcohol, lifetime exposure, colorectal cancer, prospective study, EPIC, Gastroenterology, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, ddc:610, Risk factor, Prospective cohort study, Colonic disease, Sex Characteristics, business.industry, Rectal Neoplasms, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Nutrition Assessment, Colonic Neoplasms, Alcohol intake, Female, business
Abstract: Alcohol consumption may be associated with risk of colorectal cancer (CRC), but the epidemiological evidence for an association with specific anatomical subsites, types of alcoholic beverages and current vs. lifetime alcohol intake is inconsistent. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 478,732 study subjects free of cancer at enrolment between 1992 and 2000 were followed up for an average of 6.2 years, during which 1,833 CRC cases were observed. Detailed information on consumption of alcoholic beverages at baseline (all cases) and during lifetime (1,447 CRC cases, 69% of the cohort) was collected from questionnaires. Cox proportional hazard models were used to examine the alcohol-CRC association. After adjustment for potential confounding factors, lifetime alcohol intake was significantly positively associated to CRC risk (hazard ratio, HR = 1.08, 95%CI = 1.04-1.12 for 15 g/day increase), with higher cancer risks observed in the rectum (HR = 1.12, 95%CI = 1.06-1.18) than distal colon (HR = 1.08, 95%CI = 1.01-1.16), and proximal colon (HR = 1.02, 95%CI = 0.92-1.12). Similar results were observed for baseline alcohol intake. When assessed by alcoholic beverages at baseline, the CRC risk for beer (HR = 1.38, 95%CI = 1.08-1.77 for 20-39.9 vs. 0.1-2.9 g/day) was higher than wine (HR = 1.21, 95%CI = 1.02-1.44), although the two risk estimates were not significantly different from each other. Higher HRs for baseline alcohol were observed for low levels of folate intake (1.13, 95%CI = 1.06-1.20 for 15 g/day increase) compared to high folate intake (1.03, 95%CI = 0.98-1.09). In this large European cohort, both lifetime and baseline alcohol consumption increase colon and rectum cancer risk, with more apparent risk increases for alcohol intakes greater than 30 g/day. © 2007 Wiley-Liss, Inc.
Published: 2007

21. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Pietro Ferrari, Paolo Vineis, John C. Whittaker, Anne Tjønneland, Rosario Tumino, Torgny Rasmuson, Frederike L. Büchner, Hendriek C. Boshuizen, Timothy J. Key, María Dolores Chirlaque, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Domenico Palli, Salvatore Panico, Manuela M. Bergmann, Eva Ardanaz, Majken K. Jensen, H. Bas Bueno-de-Mesquita, Jakob Linseisen, Inger T. Gram, Sabine Rohrmann, Göran Berglund, Petra H.M. Peeters, Elio Riboli, Eiliv Lund, Teresa Norat, Kim Overvad, Stavroula Soukara, María José Sánchez Pérez, Sabina Sieri, Lars Weinehall, Anja Olsen, Antonio Agudo, Naomi E. Allen, Mazda Jenab, Georgia Kyriazi, Sheila Bingham, Antonia Trichopoulou, Lars Janzon, José Ramón Quirós, Paolo Boffetta, Miren Dorronsoro, Kay-Tee Khaw, Heiner Boeing, Rohrmann, S, Linseisen, J, Boshuizen, Hc, Whittaker, J, Agudo, A, Vineis, P, Boffetta, P, Jensen, Mk, Olsen, A, Overvad, K, Tjonneland, A, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Bergmann, Mm, Boeing, H, Allen, N, Key, T, Bingham, S, Khaw, Kt, Kyriazi, G, Soukara, S, Trichopoulou, A, Panico, Salvatore, Palli, D, Sieri, S, Tumino, R, Peeters, Ph, BUENO DE MESQUITA, Hb, Buchner, Fl, Gram, It, Lund, E, Ardanaz, E, Chirlaque, Md, Dorronsoro, M, Perez, Mj, Quiros, Jr, Berglund, G, Janzon, L, Rasmuson, T, Weinehall, L, Ferrari, P, Jenab, M, Norat, T, Riboli, E., Rohrmann, S., Linseisen, J., Boshuizen, H.C., Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Jensen, M.K., Olsen, A., Overvad, K., Tjønneland, A., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Bergmann, M.M., Boeing, H., Allen, N., Key, T., Bingham, S., Khaw, K.-T., Kyriazi, G., Soukara, S., Trichopoulou, A., Panico, S., Palli, D., Sieri, S., Tumino, R., Peeters, P.H.M., Bueno-De-Mesquita, H.B., Büchner, F.L., Gram, I.T., Lund, E., Ardanaz, E., Chirlaque, M.-D., Dorronsoro, M., Pérez, M.-J.S., Quirós, J.R., Berglund, G., Janzon, L., Rasmuson, T., Weinehall, L., Ferrari, P., Jenab, M., and Norat, T.
Subjects: Adult, Male, medicine.medical_specialty, Epidemiology, lung neoplasms, Lower risk, Risk Assessment, cohort studies, Risk Factors, Interventional oncology [UMCN 1.5], Surveys and Questionnaires, Internal medicine, Determinants in Health and Disease [EBP 1], Humans, Medicine, Prospective Studies, ddc:610, Risk factor, Lung cancer, alcohol drinking, ethanol, Proportional Hazards Models, Ethanol intake and risk of lung cancer, business.industry, Incidence, Hazard ratio, Middle Aged, Anthropometry, medicine.disease, Confidence interval, European Prospective Investigation into Cancer and Nutrition, Surgery, Europe, Female, business, Follow-Up Studies, Cohort study
Abstract: Contains fulltext : 49956.pdf (Publisher’s version ) (Closed access) Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.
Published: 2006

22. Dietary macronutrient composition in relation to circulating HDL and non-HDL cholesterol: a federated individual-level analysis of cross-sectional data from adolescents and adults in 8 European studies

Author: Jildau Bouwman, Taylor A. Breuninger, Katharina Nimptsch, Holger Schulz, Sybille Koletzko, Andrea von Berg, Antonietta Robino, Axelle Hoge, Stefan Benda, Tobias Pischon, Chen Yang, Marie Standl, Ute Nöthlings, Stephanie Jeran, Demetris Avraam, Luis Castaño, Jakob Linseisen, Gunda Herberth, Nicolas Gillain, Janett Barbaresko, Michèle Guillaume, Mariona Pinart, Paolo Gasparini, Carla Harris, Anne-Françoise Donneau, Paul Burton, Marta Stelmach-Mardas, Carl Lachat, Heiner Boeing, Gemma Rojo-Martinez, Pinart, M., Jeran, S., Boeing, H., Stelmach-Mardas, M., Standl, M., Schulz, H., Harris, C., von Berg, A., Herberth, G., Koletzko, S., Linseisen, J., Breuninger, T. A., Nothlings, U., Barbaresko, J., Benda, S., Lachat, C., Yang, C., Gasparini, P., Robino, A., Rojo-Martinez, G., Castano, L., Guillaume, M., Donneau, A. -F., Hoge, A., Gillain, N., Avraam, D., Burton, P. R., Bouwman, J., Pischon, T., and Nimptsch, K.
Subjects: Male, Agriculture and Food Sciences, data sharing, carbohydrates, Blood lipids, Medicine (miscellaneous), BLOOD-PRESSURE, chemistry.chemical_compound, adults, Macronutrient composition, Medicine, adolescents, chemistry.chemical_classification, CARBOHYDRATE INTAKE, Nutrition and Dietetics, 18 COUNTRIES, adult, SATURATED FATTY-ACIDS, energy density models, Observational Studies as Topic, Editorial, CARDIOVASCULAR-DISEASE, SERUM-LIPIDS, Female, Smoking status, lipids (amino acids, peptides, and proteins), Dietary Carbohydrates, Polyunsaturated fatty acid, Adolescents, Adults, Blood Lipids, Carbohydrates, Data Integration, Data Sharing, Dietary Intake, Energy Density Models, Fatty Acids, Substitution, medicine.medical_specialty, Technology and Engineering, Adolescent, APOLIPOPROTEIN-B, blood lipids, data integration, dietary intake, fatty acids, substitution, HEART-DISEASE, GUINEA-PIG, AcademicSubjects/MED00060, Internal medicine, Humans, ddc:610, energy density model, DENSITY-LIPOPROTEIN-CHOLESTEROL, Cholesterol, business.industry, blood lipid, Cholesterol, HDL, Nutrients, Individual level, Dietary Fats, Diet, Cross-Sectional Studies, Endocrinology, chemistry, carbohydrate, Cardiovascular and Metabolic Diseases, adolescent, Non hdl cholesterol, AcademicSubjects/SCI00960, fatty acid, business
Abstract: BACKGROUND: Associations between increased dietary fat and decreased carbohydrate intake with circulating HDL and non-HDL cholesterol have not been conclusively determined. OBJECTIVE: We assessed these relations in 8 European observational human studies participating in the European Nutritional Phenotype Assessment and Data Sharing Initiative (ENPADASI) using harmonized data. METHODS: Dietary macronutrient intake was recorded using study-specific dietary assessment tools. Main outcome measures were lipoprotein cholesterol concentrations: HDL cholesterol (mg/dL) and non-HDL cholesterol (mg/dL). A cross-sectional analysis on 5919 participants (54% female) aged 13-80 y was undertaken using the statistical platform DataSHIELD that allows remote/federated nondisclosive analysis of individual-level data. Generalized linear models (GLM) were fitted to assess associations between replacing 5% of energy from carbohydrates with equivalent energy from total fats, SFAs, MUFAs, or PUFAs with circulating HDL cholesterol and non-HDL cholesterol. GLM were adjusted for study source, age, sex, smoking status, alcohol intake and BMI. RESULTS: The replacement of 5% of energy from carbohydrates with total fats or MUFAs was statistically significantly associated with 0.67mg/dL (95% CI: 0.40, 0.94) or 0.99mg/dL (95% CI: 0.37, 1.60) higher HDL cholesterol, respectively, but not with non-HDL cholesterol concentrations. The replacement of 5% of energy from carbohydrates with SFAs or PUFAs was not associated with HDL cholesterol, but SFAs were statistically significantly associated with 1.94mg/dL (95% CI: 0.08, 3.79) higher non-HDL cholesterol, and PUFAs with -3.91mg/dL (95% CI: -6.98, -0.84) lower non-HDL cholesterol concentrations. A statistically significant interaction by sex for the association of replacing carbohydrates with MUFAs and non-HDL cholesterol was observed, showing a statistically significant inverse association in males and no statistically significant association in females. We observed no statistically significant interaction by age. CONCLUSIONS: The replacement of dietary carbohydrates with fats had favorable effects on lipoprotein cholesterol concentrations in European adolescents and adults when fats were consumed as MUFAs or PUFAs but not as SFAs.
Published: 2021

23. Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition

Author: Magritt Brustad, Ruth C. Travis, Paolo Vineis, Rosario Tumino, Ann-Sofie Johansson, Elisabete Weiderpass, Beatrice Melin, Petra H.M. Peeters, Nicholas J. Wareham, Kim Overvad, José María Huerta, Martin Almquist, Fränzel J.B. Van Duijnhoven, Elisavet Valanou, Antonia Trichopoulou, H. Bas Bueno-de-Mesquita, Claudia Agnoli, Roel Vermeulen, Jakob Linseisen, Antonia Barmpitsioti, Johan Malm, Susen Becker, J. Ramón Quirós, Anna Łuczyńska, Eva Ardanaz, Carlos A. González, Mazda Jenab, Kay-Tee Khaw, Paula Jakszyn, Valentina Gallo, Giovanna Masala, Elio Riboli, Salvatore Panico, Isabelle Romieu, Guri Skeie, Brian Buijsse, Alexandra Nieters, Veronika Fedirko, Rudolf Kaaks, Sabine Rohrmann, María José Sánchez, University of Zurich, Nieters, Alexandra, uczy?ska, A, Kaaks, R, Rohrmann, S, Becker, S, Linseisen, J, Buijsse, B, Overvad, K, Trichopoulou, A, Valanou, E, Barmpitsioti, A, Masala, G, Agnoli, C, Tumino, R, Panico, Salvatore, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Peeters, Ph, Vermeulen, R, Weiderpass, E, Brustad, M, Skeie, G, Gonz?lez, Ca, Jakszyn, P, Quir?s, Jr, S?nchez, Mj, Huerta, Jm, Ardanaz, E, Melin, B, Johansson, A, Almquist, M, Malm, J, Khaw, Kt, Wareham, N, Travis, Rc, Fedirko, V, Romieu, I, Jenab, M, Gallo, V, Riboli, E, Vineis, P, and Nieters, A.
Subjects: Male, Lymphoma, Nutrition and Disease, Chronic lymphocytic leukemia, Medicine (miscellaneous), Rate ratio, Gastroenterology, Cohort Studies, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Voeding en Ziekte, Medicine, infections, Vitamin D, 0303 health sciences, Nutrition and Dietetics, Incidence, Lymphoma, Non-Hodgkin, Incidence (epidemiology), 2701 Medicine (miscellaneous), Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, 030220 oncology & carcinogenesis, vitamin-d status, 2916 Nutrition and Dietetics, Female, medicine.medical_specialty, 610 Medicine & health, 03 medical and health sciences, sun exposure, Internal medicine, Vitamin D and neurology, Humans, ddc:610, non-hodgkin-lymphoma, 030304 developmental biology, VLAG, subsequent risk, Global Nutrition, disease, Wereldvoeding, business.industry, Case-control study, association, Cancer, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), ultraviolet-radiation, medicine.disease, Diet, Leukemia, Lymphoid, Logistic Models, Case-Control Studies, Chronic Disease, Immunology, supplementation, business, chronic lymphocytic-leukemia, Follow-Up Studies
Abstract: Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >= 2y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.
Published: 2013

24. Smoking and lymphoma risk in the European prospective investigation into cancer and nutrition

Author: Pietro Ferrari, Amalia Mattiello, Kay-Tee Khaw, Eva Ardanaz, Petra H.M. Peeters, Thomas Ruediger, Paul Brennan, Sabine Rohrmann, Sheila Bingham, Göran Hallmans, María-Luisa Redondo, Ingegerd Johansson, Paolo Vineis, Stefano Rosso, Antonia Trichopoulou, Mikel Basterrechea, Carmen Martinez, Kim Overvad, Anja Olsen, Naomi E. Allen, Nikolaus Becker, Elio Riboli, Giovanna Masala, Ruth C. Travis, Bas Bueno-de-Mesquita, Rosario Tumino, Jonas Manjer, Giovanna Tagliabue, Heiner Boeing, Paolo Boffetta, Eiliv Lund, Göran Berglund, Anne Tjønneland, Dimitrios Trichopoulos, Manuela M. Bergmann, David Neasham, Rudolf Kaaks, Jakob Linseisen, María José Tormo, Alexandra Nieters, Nieters, A., Rohrmann, S., Becker, N., Linseisen, J., Ruediger, T., Overvad, K., Tjønneland, A., Olsen, A., Allen, N.E., Travis, R.C., Bingham, S., Khaw, K.-T., Ardanaz, E., Redondo, M.L., Basterrechea, M., Martinez, C., Tormo, M.-J., Rosso, S., Tagliabue, G., Masala, G., Mattiello, A., Tumino, R., Boeing, H., Bergmann, M., Kaaks, R., Trichopoulou, A., Trichopoulos, D., Peeters, P.H., Bueno-De-Mesquita, B., Boffetta, P., Brennan, P., Ferrari, P., Neasham, D., Lund, E., Berglund, G., Manjer, J., Hallmans, G., Johansson, I., Vineis, P., Riboli, E., and University of Groningen
Subjects: Questionnaires, Male, Oncology, Epidemiology, CONTROL-STUDY EPILYMPH, Smoking and lymphoma risk, DISEASE, SUBTYPES, Risk Factors, immune system diseases, Surveys and Questionnaires, hemic and lymphatic diseases, risk factors, Prospective Studies, Registries, EPSTEIN-BARR-VIRUS, B-cell lymphoma, Prospective cohort study, Lymphoma, Non-Hodgkin, Smoking, Hazard ratio, Middle Aged, Hodgkin Disease, European Prospective Investigation into Cancer and Nutrition, Europe, Female, medicine.medical_specialty, lymphoma, smoking, Internal medicine, medicine, Humans, TOBACCO SMOKING, COHORT, ddc:610, NON-HODGKINS-LYMPHOMA, Risk factor, Life Style, Proportional Hazards Models, business.industry, Cancer, medicine.disease, prospective studies, Lymphoma, Nutrition Assessment, Relative risk, Immunology, ALCOHOL-DRINKING, CIGARETTE-SMOKING, business
Abstract: Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. During 3,567,410 person-years of follow-up, 1,371 lymphoma cases (1,304 non-Hodgkin's lymphomas and 67 Hodgkin's lymphomas) were identified. Relative risk for smokers at recruitment was more than twofold higher for Hodgkin's lymphoma (hazard ratio = 2.14, 95% confidence interval: 1.18, 3.87) but was not elevated for non-Hodgkin's lymphoma (hazard ratio = 1.06, 95% confidence interval: 0.94, 1.19) and individual B-cell non-Hodgkin's lymphoma subtypes. In this prospective study, smoking appeared to increase Hodgkin's lymphoma risk consistently in both genders, whereas B-cell non-Hodgkin's lymphoma risk was not associated. Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma. © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Published: 2016

25. Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition

Author: Françoise Clavel-Chapelon, Birigit Teucher, Björn Lindkvist, Tobias Pischon, Paolo Vineis, H. Bas Bueno-de-Mesquita, Philippos Orfanos, Magritt Brustad, Aurelio Barricarte, Petra H.M. Peeters, Laudina Rodríguez, Teresa Norat, Elio Riboli, Anne Tjønneland, Pietro Ferrari, Francesca L. Crowe, Guri Skeie, Marie-Christine Boutron-Ruault, Eric J. Duell, Dagrun Engeset, Ute Nöthlings, Weimin Ye, Rosario Tumino, Mazda Jenab, Pilar Amiano, Nicholas J. Wareham, Verena A. Grote, Kay-Tee Khaw, Salvatore Panico, Sabine Rohrmann, Antonia Trichopoulou, Ioulia Goufa, Esther Molina-Montes, Suzanne M. Jeurnink, Jakob Linseisen, Dorthe Johansen, Kim Overvad, Heather Ward, Valeria Pala, Rikke Egeberg, María José Tormo, Domenico Palli, Peter D. Siersema, Heiner Boeing, Malin Sund, Nadia Slimani, Vanessa Cottet, Rohrmann, S, Linseisen, J, N?thlings, U, Overvad, K, Egeberg, R, Tj?nneland, A, Boutron Ruault, Mc, Clavel Chapelon, F, Cottet, V, Pala, V, Tumino, R, Palli, D, Panico, Salvatore, Vineis, P, Boeing, H, Pischon, T, Grote, V, Teucher, B, Khaw, Kt, Wareham, Nj, Crowe, Fl, Goufa, I, Orfanos, P, Trichopoulou, A, Jeurnink, Sm, Siersema, Pd, Peeters, Ph, Brustad, M, Engeset, D, Skeie, G, Duell, Ej, Amiano, P, Barricarte, A, Molina Montes, E, Rodr?guez, L, Tormo, Mj, Sund, M, Ye, W, Lindkvist, B, Johansen, D, Ferrari, P, Jenab, M, Slimani, N, Ward, H, Riboli, E, Norat, T, Bueno de Mesquita, Hb, University of Zurich, and Rohrmann, Sabine
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Meat, Nutritional Status, Cohort, Epic, Fish, Pancreatic Cancer, 610 Medicine & health, Risk Assessment, Poultry, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pancreatic cancer, Internal medicine, Fish Products, medicine, Animals, Humans, 1306 Cancer Research, Prospective Studies, 030212 general & internal medicine, ddc:610, Prospective cohort study, Life Style, 2. Zero hunger, business.industry, Fishes, Feeding Behavior, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Middle Aged, medicine.disease, Diet, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Pancreatic Neoplasms, 030220 oncology & carcinogenesis, Relative risk, Red meat, Female, 2730 Oncology, business, Risk assessment, Cohort study
Abstract: Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000 were included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases have been observed. Calibrated relative risks (RRs) and 95% confidence intervals (CIs) were computed using multivariable-adjusted Cox hazard regression models. The consumption of red meat (RR per 50 g increase per day = 1.03, 95% CI = 0.93-1.14) and processed meat (RR per 50 g increase per day = 0.93, 95% CI = 0.71-1.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day = 1.72, 95% CI = 1.04-2.84); however, there was no association with fish consumption (RR per 50 g increase per day = 1.22, 95% CI = 0.92-1.62). Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings.
Published: 2016

26. DNA adducts and lung cancer risk: a prospective study

Author: H. Bas Bueno-de-Mesquita, Herman Autrup, Heiner Boeing, Paolo Vineis, Armelle Munnia, Aurelio Barricarte, Ole Raaschou-Nielsen, Seymour Garte, Carlos González, Fabrizio Veglia, Petra H.M. Peeters, Carmen Martinez, Carmen Navarro, J. Ramón Quirós, Elio Riboli, Antonia Trichopoulou, Emmanuelle Gormally, Merethe Kumle, Göran Berglund, Dimitrios Trichopoulos, Salvatore Panico, Timothy J. Key, Lars Janzon, Vittorio Krogh, Kim Overvad, Luisa Airoldi, Rudolf Kaaks, Michal Krzyzanowski, Pierre Hainaut, Giuseppe Matullo, Bengt Järvholm, Marco Peluso, Alison M. Dunning, Gerard Hoek, Rosario Tumino, Françoise Clavel-Chapelon, Anna Kaladidi, Christian Malaveille, Nicholas E. Day, Domenico Palli, J. Linseisen, Rodolfo Saracci, Miren Dorronsoro, Peluso, M, Munnia, A, Hoek, G, Krzyzanowski, M, Veglia, F, Airoldi, L, Autrup, H, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Gormally, E, Matullo, G, Overvad, K, RAASCHOU NIELSEN, O, CLAVEL CHAPELON, F, Linseisen, J, Boeing, H, Trichopoulou, A, Trichopoulos, D, Kaladidi, A, Palli, D, Krogh, V, Tumino, R, Panico, Salvatore, BUENO DE MESQUITA, Hb, Peeters, Ph, Kumle, M, Gonzalez, Ca, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, Jr, Berglund, G, Janzon, L, Jarvholm, B, Day, Ne, Key, Tj, Saracci, R, Kaaks, R, Riboli, E, Vineis, P., and Faculteit Diergeneeskunde
Subjects: Adult, Male, pharynx, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Gastroenterology, lung, DNA Adducts, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, DNA adduct, medicine, Humans, air pollutants, ddc:610, Prospective Studies, Risk factor, Prospective cohort study, Lung cancer, Aged, 030304 developmental biology, larynx, 0303 health sciences, business.industry, Respiratory disease, Cancer, Odds ratio, Middle Aged, Diergeneeskunde (DGNK), medicine.disease, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Dna adducts, bladder cancer, Oncology, 13. Climate action, Case-Control Studies, 030220 oncology & carcinogenesis, Immunology, Female, business
Abstract: Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx; n = 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using 32P postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.93] when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O3) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O3 indicates a possible role for photochemical smog in determining DNA damage.
Published: 2016

27. Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort

Author: Andrew Rundle, Kim Overvad, H. Bas Bueno-de-Mesquita, N. F. Johnsen, Mandy Schulz, Petra H.M. Peeters, Jakob Linseisen, Christine M. Friedenreich, Anne E. Cust, Carmen Martinez, María Dolores Chirlaque, Teresa Norat, Evelyn M. Monninkhof, Karen Steindorf, Anne Tjønneland, Hendriek C. Boshuizen, Françoise Clavel-Chapelon, Ole Raaschou-Nielsen, Sheila Bingham, Antonia Trichopoulou, Lars Janzon, Maria Koliva, José Ramón Quirós, Timothy J. Key, Nerea Larrañaga, Antonio Agudo, Domenico Palli, Sabine Rohrmann, Vittorio Krogh, Aurelio Barricarte, Elio Riboli, Victoria Kalapothaki, Mazda Jenab, Kay-Tee Khaw, Salvatore Panico, Marie-Christine Boutron-Ruault, Göran Berglund, Heiner Boeing, Fabrizio Veglia, Paolo Vineis, Rosario Tumino, Steindorf, K, Friedenreich, C, Linseisen, J, Rohrmann, S, Rundle, A, Veglia, F, Vineis, P, Johnsen, Nf, Tjonneland, A, Overvad, K, RAASCHOU NIELSEN, O, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Schulz, M, Boeing, H, Trichopoulou, A, Kalapothaki, V, Koliva, M, Krogh, V, Palli, D, Tumino, R, Panico, Salvatore, Monninkhof, E, Peeters, Ph, Boshuizen, Hc, BUENO DE MESQUITA, Hb, Chirlaque, Md, Agudo, A, Larranaga, N, Quiros, Jr, Martinez, C, Barricarte, A, Janzon, L, Berglund, G, Bingham, S, Khaw, Kt, Key, Tj, Norat, T, Jenab, M, Cust, A, and Riboli, E.
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Physical exercise, Motor Activity, Risk Assessment, Risk Factors, Occupational Exposure, Odds Ratio, Medicine, Humans, Nutritional Physiological Phenomena, Prospective Studies, ddc:610, Risk factor, Sex Distribution, Prospective cohort study, Lung cancer, Aged, Proportional Hazards Models, business.industry, Odds ratio, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Relative risk, Physical therapy, Recreation, Female, business, Demography, Cohort study
Abstract: Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors.
Published: 2016

28. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition

Author: Salvatore Panico, Emmanuelle Kesse, Pietro Ferrari, Bertrand Hémon, Anne Tjønneland, Eiliv Lund, Guri Skeie, Timothy J. Key, Kim Overvad, Göran Berglund, H. Bas Bueno-de-Mesquita, Carmen Navarro, Mazda Jenab, Teresa Norat, Iréne Mattisson, Nicholas E. Day, Carlos González, Dagrun Engeset, María José Sánchez, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Françoise Clavel, Mathieu Mazuir, Elio Riboli, Petra H.M. Peeters, Yannis Tountas, Göran Hallmans, Manuela M. Bergmann, Anja Olsen, Sheila Bingham, Nadia Slimani, Antonia Trichopoulou, Richard Palmqvist, Dimitrios Trichopoulos, Heiner Boeing, Rosario Tumino, Jakob Linseisen, Franco Berrino, Paolo Vineis, Rodolfo Saracci, J. Ramón Quirós, Eva Ardanaz, Kay-Tee Khaw, Domenico Palli, Alexandra Nieters, Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology, Nutrition Unit, MRC Dunn Human, Department of Clinical Epidemiology, Aarhus University Hospital, Department of Cardiology and Department of Clinical Epidemiology, Institute of Cancer Epidemiology, Danish Cancer Society, Nutrition, hormones et cancer: épidémiologie et prévention (E3N), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association, Division of Clinical Epidemiology, Deutches Krebsforschungszentrum, Department of Hygiene and Epidemiology, University of Athens Medical School [Athens], Epidemiology Unit, Istituto Tumori, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Ragusa Cancer Registry, Azienda Ospedaliera Civile MP, University of Torino and CPO-Piemonte, Università degli studi di Torino (UNITO), Center for Nutrition and Health, National Institute of Public Health and Environment, Julius Center for Health Sciences and Primary Care, VU University Medical Center [Amsterdam], Institute of Community Medicine, University of Tromsø (UiT), Public Health Institute of Navarra, Department of Epidemiology, Epidemiology Department, Health Council of Murcia, Public Health and Health Planning Directorate, Andalusian School of Public Health [Granada], Malmö Diet and Cancer Study, Lund University [Lund], Department of Nutritional Research, Umeå University, Department of Medical Biosciences, Pathology, Strangeways Research Laboratory, Clinical Gerontology Unit, University of Cambridge [UK] (CAM), Cancer Research UK Epidemiology Unit, University of Oxford [Oxford], The work described in this article was carried out with financial support of the 'Europe Against Cancer Program' of the European Commission (SANCO), the Danish Cancer Society, German Cancer Aid, Ligue Nationale contre le Cancer, the 3M Company, INSERM, the German Cancer Research Center, the GermanFederal Ministry of Education and Research, the Dutch Ministry of Public Health, Welfare and Sports, the National Cancer Registry and the Regional Cancer Registries Amsterdam, East and Maastricht of The Netherlands, the Norwegian Cancer Society, the Norwegian Research Council, the Health Research Fund (FIS) of the Spanish Ministry of Health, the Greek Ministry of Health, the Greek Ministry of Education, the Italian Association for Research on Cancer, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and ISCIII, Red de Centros RCESP, C03/09, the Swedish Cancer Society, the Swedish Scientific Council, the Regional Government of Skane, Sweden, Cancer Research UK, the Medical Research Council, U.K., the Stroke Association, U.K., the British Heart Foundation, the Department of Health, U.K., the Food Standards Agency, U.K., and the Wellcome Trust, U.K., University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Torino = University of Turin (UNITO), University of Oxford, Clavel-Chapelon, F., Norat, T, Bingham, S, Ferrari, P, Slimani, N, Jenab, M, Mazuir, M, Overvad, K, Olsen, A, Tjonneland, A, Clavel, F, BOUTRON RUAULT, Mc, Kesse, E, Boeing, H, Bergmann, Mm, Nieters, A, Linseisen, J, Trichopoulou, A, Trichopoulos, D, Tountas, Y, Berrino, F, Palli, D, Panico, Salvatore, Tumino, R, Vineis, P, BUENO DE MESQUITA, Hb, Peeters, Ph, Engeset, D, Lund, E, Skeie, G, Ardanaz, E, Gonzalez, C, Navarro, C, Quiros, Jr, Sanchez, Mj, Berglund, G, Mattisson, I, Hallmans, G, Palmqvist, R, Day, Ne, Khaw, Kt, Key, Tj, SAN JOAQUIN, M, Hemon, B, Saracci, R, Kaaks, R, and Riboli, E.
Subjects: Dietary Fiber, Male, Cancer Research, 030309 nutrition & dietetics, Colorectal cancer, MESH: Food Habits, Gastroenterology, Poultry, MESH: Proportional Hazards Models, 0302 clinical medicine, Risk Factors, MESH: Poultry, Surveys and Questionnaires, Odds Ratio, MESH: Animals, Prospective Studies, Prospective cohort study, 2. Zero hunger, MESH: Aged, MESH: Meat, 0303 health sciences, MESH: Middle Aged, MESH: Risk, Fishes, Absolute risk reduction, MESH: Life Style, Confounding Factors, Epidemiologic, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Research Design, 030220 oncology & carcinogenesis, Income, Red meat, Educational Status, Population study, Female, Colorectal Neoplasms, Adult, medicine.medical_specialty, Meat, [SDV.CAN]Life Sciences [q-bio]/Cancer, Risk Assessment, Article, MESH: Multivariate Analysis, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, medicine, Animals, Humans, ddc:610, European Union, Risk factor, Life Style, Aged, Proportional Hazards Models, MESH: Humans, business.industry, MESH: Questionnaires, Cancer, MESH: Adult, Feeding Behavior, medicine.disease, MESH: Male, MESH: Odds Ratio, MESH: Prospective Studies, Surgery, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, MESH: Fishes, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Multivariate Analysis, MESH: Dietary Fiber, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, MESH: Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, MESH: Colorectal Neoplasms
Abstract: Background: Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing. Methods: We prospectively followed 478 040 men and women from 10 European countries who were free of cancer at enrollment between 1992 and 1998. Information on diet and lifestyle was collected at baseline. After a mean follow-up of 4.8 years, 1329 incident colorectal cancers were documented. We examined the relationship between intakes of red and processed meat, poultry, and fish and colorectal cancer risk using a proportional hazards model adjusted for age, sex, energy (nonfat and fat sources), height, weight, work-related physical activity, smoking status, dietary fiber and folate, and alcohol consumption, stratified by center. A calibration substudy based on 36 994 subjects was used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. All statistical tests were two-sided. Results: Colorectal cancer risk was positively associated with intake of red and processed meat (highest [>160 g/day] versus lowest [80 g/day versus
Published: 2016

29. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Petra H.M. Peeters, C. Navarro, Françoise Clavel-Chapelon, H. B. Bueno-De-Mesquita, Tonje Braaten, Kim Overvad, Salvatore Panico, Teresa Norat, Marina Touillaud, E. Wirfält, Eva Ardanaz, M. C. Boutron-Ruault, Rudolf Kaaks, Sabina Sieri, Inger T. Gram, Sabine Rohrmann, Martine M. Ros, Carlos Martinez, Elio Riboli, Sheila Bingham, Domenico Palli, Antonia Trichopoulou, Timothy J. Key, Jonas Manjer, Lambertus A. Kiemeney, Andrew W. Roddam, Antonio Agudo, Rosario Tumino, Louise Hansen, Torgny Rasmuson, C. H. van Gils, K-T Khaw, Paolo Vineis, Dominique S. Michaud, Heiner Boeing, Jakob Linseisen, Dimosthenis Zylis, Eiliv Lund, Nadia Slimani, Graham Byrnes, Anne Tjønneland, Ole Raaschou-Nielsen, U. Nöthlings, Hendriek C. Boshuizen, Göran Hallmans, L. Arriola, P. Bofetta, Frederike L. Büchner, Vardis Dilis, L. Rodríguez, Büchner, Fl, Bueno de Mesquita, Hb, Linseisen, J, Boshuizen, Hc, Kiemeney, La, Rosmm, Overvad, K, Hansen, L, Tjonneland, A, Raaschou Nielsen, O, Clavel Chapelon, F, Boutron Ruault, Mc, Touillaud, M, Kaaks, R, Rohrmann, S, Boeing, H, Nöthlings, U, Trichopoulou, A, Zylis, D, Dilis, V, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, Salvatore, Peeters, Ph, van Gils, Ch, Lund, E, Gram, It, Braaten, T, Martinez, C, Agudo, A, Arriolal, Ardanaz, E, Navarro, C, Rodríguez, L, Manjer, J, Wirfält, E, Hallmans, G, Rasmusont, Key, Tj, Roddam, Aw, Bingham, S, Khaw, Kt, Slimani, N, Bofetta, P, Byrnes, G, Noratt, Michaud, D, and Riboli, E.
Subjects: Oncology, Male, Cancer Research, Pathology, Lung Neoplasms, Aetiology, screening and detection [ONCOL 5], Antioxidants, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Vegetables, Odds Ratio, Medicine, Non-small-cell lung carcinoma, Prospective Studies, Carcinoma, Small Cell, Prospective cohort study, Public, Environmental & Occupational Health, 2. Zero hunger, 0303 health sciences, Smoking, WOMEN, MEN, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Large cell carcinoma, Research Design, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, Small Cell Lung Carcinoma, Risk assessment, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, DIET, Fruits, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Young Adult, Internal medicine, Humans, COHORT, Small cell lung carcinoma, ddc:610, Lung cancer, 030304 developmental biology, Proportional Hazards Models, Original Paper, Science & Technology, business.industry, Large cell, Odds ratio, medicine.disease, ONCOLOGY, Evaluation of complex medical interventions [NCEBP 2], Fruit, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI, Multivariate Analysis, business
Abstract: Contains fulltext : 88547.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. METHODS: Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. RESULTS: During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes. CONCLUSION: We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas. 01 maart 2010
Published: 2009

30. Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Naomi E. Allen, Pietro Ferrari, Elisabet Wirfält, H. Bas Bueno-de-Mesquita, Salvatore Panico, María Dolores Chirlaque, Heiner Boeing, Timothy J. Key, Teresa Norat, J. Ramón Quirós, Tobias Pischon, Manuela M. Bergmann, Domenico Palli, Antonio Agudo, Cornelia Weikert, Sabine Rohrmann, Jakob Linseisen, Paolo Vineis, Nadia Slimani, Thomas Dietrich, María José Sánchez, Eiliv Lund, Rosario Tumino, Ingegerd Johansson, Mazda Jenab, Aurelio Barricarte, Marie-Christine Boutron-Ruault, Alina Vrieling, Anne Tjønneland, Sheila Bingham, Pilar Amiano, Antonia Trichopoulou, Lars Weinehall, Kay-Tee Khaw, Elio Riboli, Petra H.M. Peeters, Valeria Pala, Kim Overvad, Anja Olsen, Françoise Clavel-Chapelon, Weikert, C, Dietrich, T, Boeing, H, Bergmann, Mm, Boutron Ruault, Mc, Clavel Chapelon, F, Allen, N, Key, T, Lund, E, Olsen, A, Tjønneland, A, Overvad, K, Rohrmann, S, Linseisen, J, Pischon, T, Trichopoulou, A, Weinehall, L, Johansson, I, Sánchez, Mj, Agudo, A, Barricarte, A, Amiano, P, Chirlaque, Md, Quirós, Jr, Wirfalt, E, Peeters, Ph, Bueno de Mesquita, Hb, Vrieling, A, Pala, V, Palli, D, Vineis, P, Tumino, R, Panico, Salvatore, Bingham, S, Khaw, Kt, Norat, T, Jenab, M, Ferrari, P, Slimani, N, and Riboli, E.
Subjects: Male, Cancer Research, medicine.medical_specialty, Alcohol Drinking, Esophageal Neoplasms, Population, Risk Factors, Internal medicine, medicine, Humans, ddc:610, Prospective Studies, Risk factor, Prospective cohort study, education, Laryngeal Neoplasms, Proportional Hazards Models, Mouth neoplasm, education.field_of_study, business.industry, Pharyngeal Neoplasms, European Prospective Investigation into Cancer and Nutrition, Europe, Endocrinology, Oncology, Epidermoid carcinoma, Relative risk, Carcinoma, Squamous Cell, Female, Mouth Neoplasms, business, Cohort study
Abstract: Udgivelsesdato: 2009-Jul-15 Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression was applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval:1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95%CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95%CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life.
Published: 2009

31. Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition

Author: María Dolores Chirlaque, Rudolf Kaaks, Valentina Gallo, Sara Grioni, Nikolaus Becker, Aneire E. Khan, Martine M. Ros, Anne Tjønneland, Amalia Mattiello, Roel Vermeulen, Naomi E. Allen, Åsa Ågren, Petra H.M. Peeters, Vasiliki Benetou, H. Bas Bueno-de-Mesquita, Nerea Larrañaga, Ole Raaschou-Nielsen, Jakob Linseisen, Kim Overvad, Nadia Slimani, Teresa Norat, Eiliv Lund, Eva Ardanaz, Paula Jakszyn, Hans Erik Johnsen, Giovanna Masala, Elio Riboli, Manuela M. Bergmann, Göran Hallmans, Heiner Boeing, Kay-Tee Khaw, Alexandra Nieters, Göran Berglund, Adamina Losada, Sheila Bingham, Antonia Trichopoulou, Jonas Manjer, Sabine Rohrmann, Theodora Psaltopoulou, Paolo Boffetta, Paolo Vineis, Carmen Martinez-Garcia, Rosario Tumino, Pietro Ferrari, Timothy J. Key, Khan, A.E., Gallo, V., Linseisen, J., Kaaks, R., Rohrmann, S., Raaschou-Nielsen, O., Tjønneland, A., Johnsen, H.E., Overvad, K., Bergmann, M.M., Boeing, H., Benetou, V., Psaltopoulou, T., Trichopoulou, A., Masala, G., Mattiello, A., Grioni, S., Tumino, R., Vermeulen, R.C.H., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Ros, M.M., Lund, E., Ardanaz, E., Chirlaque, M.-D., Jakszyn, P., Larrañaga, N., Losada, A., Becker, N., Nieters, A., Martínez-García, C., Ågren, Å., Hallmans, G., Berglund, G., Manjer, J., Allen, N.E., Key, T.J., Bingham, S., Khaw, K.T., Slimani, N., Ferrari, P., Boffetta, P., Norat, T., Vineis, P., and Riboli, E.
Subjects: Adult, Male, Risk, Oncology, medicine.medical_specialty, Diabetes risk non-Hodgkin's lymphoma multiple myeloma European Prospective Investigation Cancer Nutrition, Nutritional Sciences, Comorbidity, Diabetes Complications, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Prospective Studies, ddc:610, Risk factor, Prospective cohort study, Multiple myeloma, Aged, Hematology, business.industry, Lymphoma, Non-Hodgkin, Cancer, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Lymphoma, Non-Hodgkin's lymphoma, Europe, Diabetes Mellitus, Type 2, Immunology, Female, Multiple Myeloma, business, Follow-Up Studies
Abstract: Background: Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but their etiology remains largely unknown. Evidence suggests that certain medical conditions may be linked, through immunosuppression, to the risk of non-Hodgkin's lymphoma. Multiple myeloma is a neoplasm of plasma cells that accounts for approximately 15% of lymphopoietic cancers. Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents. Design and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,213 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma (594 men; 619 women) were identified during a follow-up of 8.5 years. Cox proportional hazard models were used to explore the association between self-reported diabetes, diagnosed after 30 years of age, and the risk of non-Hodgkin's lymphoma overall and multiple myeloma and various lymphoma subtypes. Results: We found no association between a personal history of diabetes and the risk of non-Hodgkin's lymphoma overall in men (HR: 1.28, 95% CI: 0.89-1.84), in women (HR: 0.71, 95% CI: 0.41-1.24), or in men and women combined (HR: 1.09, 95% CI: 0.80-1.47). Among the B-non-Hodgkin's lymphoma subtypes, we observed a statistically significant increased risk of B-cell chronic lymphocytic leukemia (HR: 2.0, 95% CI: 1.04-3.86) in men, but not in women (HR: 1.07, 95% CI: 0.33-3.43). Conclusions: This prospective study did not provide evidence for a role of self-reported diabetes in the etiology of non-Hodgkin's lymphoma overall or multiple myeloma. We found an increased risk of B-cell chronic lymphocytic leukemia among men with diabetes, but not among women. We hypothesize that diabetes may not play a causal role in the etiology of B-cell chronic lymphocytic leukemia, though the underlying pathogenic mechanisms of both disorders may include shared genetic, host and/or environmental susceptibility factors. ©2008 Ferrata Storti Foundation.
Published: 2008

32. Dietary Carbohydrates, Glycemic Index, Glycemic Load, and Endometrial Cancer Risk within the European Prospective Investigation into Cancer and Nutrition Cohort

Author: Marit M.E. Van Bakel, Françoise Clavel-Chapelon, Martin Lajous, J. Ramón Quirós, H. Bas Bueno-de-Mesquita, Anne E. Cust, Eva Ardanaz, Carmen Navarro, Paula Jakszyn, Kim Overvad, Heiner Boeing, Rosario Tumino, Göran Hallmans, Guri Skeie, Anne Tjønneland, Mazda Jenab, Marie-Christine Boutron-Ruault, Eva Lundin, Naomi E. Allen, Sabina Sieri, Carlotta Sacerdote, Ute Nöthlings, Sheila Bingham, Elio Riboli, Carine Biessy, Nadia Slimani, Nerea Larrañaga, Göran Berglund, Jakob Linseisen, Elisabet Wirfält, Salvatore Panico, Rudolf Kaaks, Huaidong Du, Kay-Tee Khaw, Martine Laville, Domenico Palli, Dagrun Engeset, Petra H.M. Peeters, Pietro Ferrari, Anja Olsen, Timothy J. Key, María José Sánchez, Inger T. Gram, Sabine Rohrmann, University of Groningen, Cust, Ae, Slimani, N, Kaaks, R, VAN BAKEL, M, Biessy, C, Ferrari, P, Laville, M, Tjonneland, A, Olsen, A, Overvad, K, Lajous, M, CLAVEL CHAPELON, F, BOUTRON RUAULT, Mc, Linseisen, J, Rohrmann, S, Nothlings, U, Boeing, H, Palli, D, Sieri, S, Panico, Salvatore, Tumino, R, Sacerdote, C, Skeie, G, Engeset, D, Gram, It, Quiros, Jr, Jakszyn, P, Sanchez, Mj, Larranaga, N, Navarro, C, Ardanaz, E, Wirfalt, E, Berglund, G, Lundin, E, Hallmans, G, BUENO DE MESQUITA, Hb, Du, H, Peeters, Ph, Bingham, S, Khaw, Kt, Allen, Ne, Key, Tj, Jenab, M, and Riboli, E.
Subjects: Epidemiology, cohort studies, Risk Factors, Surveys and Questionnaires, dietary carbohydrates, Prospective Studies, IOWA WOMENS HEALTH, Prospective cohort study, FOODS, INSULIN SENSITIVITY, Incidence, Starch, Middle Aged, dietary fiber, IGF-I, European Prospective Investigation into Cancer and Nutrition, Europe, Glycemic index, Female, insulin, medicine.medical_specialty, endometrial neoplasms, Hormone Replacement Therapy, Diet therapy, Diet Surveys, Risk Assessment, C-PEPTIDE, Internal medicine, Glycemic load, Confidence Intervals, medicine, Humans, nutrition assessment, European Union, ddc:610, Risk factor, Proportional Hazards Models, DIANA RANDOMIZED-TRIAL, business.industry, Feeding Behavior, Confidence interval, ENERGY-INTAKE, PHYSICAL-ACTIVITY, Endocrinology, FAT, Relative risk, Multivariate Analysis, glycemic index, MEASUREMENT ERROR, diet, business, Follow-Up Studies
Abstract: The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates P-heterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.
Published: 2007

33. Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Nadia Slimani, Heiner Boeing, Eva Ardanaz, Jonas Manjer, Kim Overvad, Elio Riboli, Göran Berglund, Giovanna Masala, María Dolores Chirlaque, Kay-Tee Khaw, Carla H. van Gils, Hans Erik Johnsen, Nerea Larrañaga, Pietro Ferrari, Petra H.M. Peeters, Sheila Bingham, Martine M. Ros, Theodora Psaltopoulou, Antonia Trichopoulou, Thomas Rüdiger, Rosario Tumino, H. Bas Bueno-de-Mesquita, Eiliv Lund, Teresa Norat, Amalia Mattiello, Timothy J. Key, Vasiliki Benetou, Alexandra Nieters, Adamina Losada, Paolo Vineis, Paula Jakszyn, Jakob Linseisen, Rudolf Kaaks, Naomi E. Allen, Nikolaus Becker, Carmen Martinez-Garcia, Sabine Rohrmann, Anne Tjønneland, Vittorio Krogh, Ole Raaschou-Nielsen, Manuela M. Bergmann, Göran Hallmans, Paolo Boffetta, Åsa Ågren, Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Rüdiger, T., Raaschou-Nielsen, O., Tjønneland, A., Johnsen, H.E., Overvad, K., Kaaks, R., Bergmann, M.M., Boeing, H., Benetou, V., Psaltopoulou, T., Trichopoulou, A., Masala, G., Mattiello, A., Krogh, V., Tumino, R., Gils, C.H.V., Peeters, P.H.M., Bueno-De-Mesquita, H.B., Ros, M.M., Lund, E., Ardanaz, E., Chirlaque, M.-D., Jakszyn, P., Larrañaga, N., Losada, A., Martínez-García, C., Ågren, Å., Hallmans, G., Berglund, G., Manjer, J., Allen, N.E., Key, T.J., Bingham, S., Khaw, K.T., Slimani, N., Ferrari, P., Boffetta, P., Norat, T., Vineis, P., and Riboli, E.
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Lymphoma, Cohort Studies, Risk Factors, hemic and lymphatic diseases, Internal medicine, Vegetables, Fruit vegetable consumption lymphoma risk European Prospective Investigation Cancer Nutrition (EPIC), Epidemiology, medicine, Humans, ddc:610, Prospective cohort study, business.industry, Incidence, Incidence (epidemiology), Hazard ratio, Feeding Behavior, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Quartile, Fruit, Immunology, Female, business, Cohort study
Abstract: Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation. © 2007 Springer Science+Business Media B.V.
Published: 2007

34. Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Jakob Linseisen, Carla H. van Gils, Françoise Clavel, Elio Riboli, Göran Berglund, Annekatrin Lukanova, H. Bas Bueno-de-Mesquita, Timothy J. Key, Salvatore Panico, Mandy Schulz, Petra H.M. Peeters, Dimitrios Trichopolos, Kim Overvad, Eva Lundin, Christina Bamia, Carmen Navarro, Anja Olsen, Nerea Larrañaga, Anne Tjønneland, Laure Dossus, Domenico Palli, Carmen Martinez-Garcia, Kay-Tee Khaw, Jenny Chang-Claude, Mette Skytte Tetsche, J. Ramón Quirós, Eva Ardanaz, Guillem Pera, Rosario Tumino, Carlotta Sacerdote, Franco Berrino, Sabina Rinaldi, Rudolf Kaaks, Heiner Boeing, Eiliv Lund, Naomi E. Allen, Sheila Bingham, Antonia Trichopoulou, Peeters, Ph, Lukanova, A, Allen, N, Berrino, F, Key, T, Dossus, L, Rinaldi, S, VAN GILS, Ch, BUENO DE MESQUITA, Hb, Boeing, H, Schulz, M, CHANG CLAUDE, J, Linseisen, J, Panico, Salvatore, Sacerdote, C, Palli, D, Tumino, R, Trichopoulou, A, Trichopolos, D, Bamia, C, Larranaga, N, Ardanaz, E, Pera, G, Quiros, Jr, MARTINEZ GARCIA, C, Navarro, C, Bingham, Sa, Khaw, Kt, Clavel, F, Tjonneland, A, Olsen, A, Overvad, K, Tetsche, M, Lund, E, Lundin, E, Berglund, G, Riboli, E, and Kaaks, R.
Subjects: Adult, Oncology, Cancer Research, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Biology, Endocrinology, Risk Factors, Internal medicine, medicine, Humans, Neoplasms, Glandular and Epithelial, Prospective Studies, ddc:610, Insulin-Like Growth Factor I, Prospective cohort study, Aged, Ovarian Neoplasms, Case-control study, Odds ratio, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Insulin-Like Growth Factor Binding Protein 3, Premenopause, Case-Control Studies, Relative risk, Female, Ovarian cancer, Body mass index, Hormone
Abstract: We set out to study the relationship between circulating levels of IGF-I and its major binding protein (IGFBP-3) in relation to ovarian cancer risk. We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Levels of IGF-I and IGFBP-3 were measured in prediagnostic serum samples of 214 women who subsequently developed ovarian cancer, and 388 matched control subjects. Conditional logistic regression models were used to estimate relative risks of ovarian cancer by tertiles of IGF-I and IGFBP-3 levels. For all women, there was no association between the circulating IGF-I or IGFBP-3 levels and the risk of ovarian cancer. However, among women diagnosed with ovarian cancer aged 55 or younger, the relative risk was higher in the middle or top tertiles of serum IGF-I, when compared with women in the lowest tertile (odds ratios (OR) = 1.8 (95%CI 0.7–4.3) and OR = 2.4 (95%CI 0.9–6.4); Ptrend = 0.08) respectively. These results were adjusted for body mass index, previous hormone use, fertility problems, and parity. Restricting the analysis to women who were premenopausal at blood donation, relative risks for ovarian cancer diagnosed before age 55 were higher (OR = 5.1 (95%CI 1.5–18.2) and OR = 5.6 (95%CI 1.5–20.8) respectively, for second and third tertiles; Ptrend = 0.02). Adjustment for serum IGFBP-3 levels only slightly attenuated relative risk estimates. Relations between IGFBP-3 and ovarian cancer before age 55 were in the same direction as for IGF-I, but less strong and statistically not significant. In women aged over 55, there was no association between serum IGF-I or IGFBP-3 and ovarian cancer risk. Our results suggest that the circulating levels of IGF-I may play a potentially important role in the development of ovarian cancer in women of a pre- or perimenopausal age.
Published: 2007

35. Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Author: Joan Sabaté, Fátima Carneiro, Timothy J. Key, U. Mahlke, Naomi E. Allen, Göran Hallmans, Larraitz Arriola, Mathilde Touvier, Petra H.M. Peeters, Salvatore Panico, Rosario Tumino, Kim Overvad, Gabriele Nagel, Elio Riboli, Sheila Bingham, Anja Olsen, Giovanna Masala, Kay-Tee Khaw, Antonia Trichopoulou, Hendrik B. Bueno-de-Mesquita, Domenico Palli, Jakob Linseisen, Teresa Norat, Rudolf Kaaks, Roger Stenling, Aurelio Barricarte, Mazda Jenab, Françoise Clavel-Chapelon, Carmen Navarro Sánchez, Guiseppe Del Giudice, Marie-Christine Boutron-Ruault, Anne Tjønneland, Androniki Naska, Eiliv Lund, Marlin D. Friesen, Guillem Pera, Nadia Slimani, Vittorio Krogh, María José Sánchez, Eleni Oikonomou, Heiner Boeing, Göran Berglund, José Ramón Quirós, Mattijs E. Numans, Frederike L. Büchner, Carlotta Sacerdote, Mandy Schulz, Carlos A. González, Pietro Ferrari, Jenab, M, Riboli, E, Ferrari, P, Sabate, J, Slimani, N, Norat, T, Friesen, M, Tjonneland, A, Olsen, A, Overvad, K, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Touvier, M, Boeing, H, Schulz, M, Linseisen, J, Nagel, G, Trichopoulou, A, Naska, A, Oikonomou, E, Krogh, V, Panico, Salvatore, Masala, G, Sacerdote, C, Tumino, R, Peeters, Ph, Numans, Me, BUENO DE MESQUITA, Hb, Buchner, Fl, Lund, E, Pera, G, Sanchez, Cn, Sanchez, Mj, Arriola, L, Barricarte, A, Quiros, Jr, Hallmans, G, Stenling, R, Berglund, G, Bingham, S, Khaw, Kt, Key, T, Allen, N, Carneiro, F, Mahlke, U, DEL GIUDICE, G, Palli, D, Kaaks, R, and Gonzalez, Ca
Subjects: Vitamin, Male, Cancer Research, medicine.medical_specialty, Ascorbic Acid, Gastroenterology, Geneeskunde, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Interventional oncology [UMCN 1.5], Stomach Neoplasms, Internal medicine, Determinants in Health and Disease [EBP 1], Medicine, Humans, ddc:610, Prospective Studies, Risk factor, Prospective cohort study, Aged, 2. Zero hunger, Vitamin C, Helicobacter pylori, business.industry, Incidence, Case-control study, General Medicine, Odds ratio, Middle Aged, Ascorbic acid, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Endocrinology, Logistic Models, chemistry, 030220 oncology & carcinogenesis, Case-Control Studies, Dietary Supplements, 030211 gastroenterology & hepatology, Female, business
Abstract: Contains fulltext : 51396.pdf (Publisher’s version ) (Closed access) Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited, particularly so for blood measures of vitamin C. The objective of this study was to determine the association of plasma and dietary vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 European countries. Using a fluorometric method, vitamin C was measured in pre-diagnostic plasma from 215 GC cases (matched controls = 416). Conditional logistic regression models adjusted by body mass index, total energy intake, smoking status/duration/intensity and Helicobacter pylori infection status were used to estimate relative cancer risks. No association with GC risk was observed for dietary vitamin C, whereas an inverse GC risk was observed in the highest versus lowest quartile of plasma vitamin C [odds ratio (OR) = 0.55, 95% confidence interval (CI) = 0.31-0.97, P(trend) = 0.043], which was maintained after exclusion of cases with
Published: 2006

36. C-peptide, IGF-I, sex-steroid hormones and adiposity

Author: Petra H.M. Peeters, Naomi E. Allen, H. Bas Bueno-de-Mesquita, Valeria Pala, Françoise Clavel-Chapelon, Anne Tjønneland, Laure Dossus, Gabriele Nagel, Teresa Norat, Kim Overvad, M. J. Tormo, J. R. Quirós, Carmen Martinez-Garcia, Irene D. Bezemer, Sheila Bingham, Antonio Agudo, Søren Paaske Johnsen, Bertrand Hémon, Antonia Trichopoulou, Anja Olsen, Paolo Vineis, Carla H. van Gils, Nikos Baibas, Sabina Rinaldi, Eva Ardanaz, Petra H. Lahmann, Heiner Boeing, D. Zilis, Rosario Tumino, Emmanuelle Kesse, Salvatore Panico, Elio Riboli, Bertrand Tehard, Paulus A.H. van Noord, Jakob Linseisen, Andrew W. Roddam, Rudolf Kaaks, Pilar Amiano, Kay-Tee Khaw, Domenico Palli, University of Groningen, Bezemer, Id, Rinaldi, S, Dossus, L, Gils, Ch, Peeters, Ph, Noord, Pa, BUENO DE MESQUITA, Hb, Johnsen, Sp, Overvad, K, Olsen, A, Tjonneland, A, Boeing, H, Lahmann, Ph, Linseisen, J, Nagel, G, Allen, N, Roddam, A, Bingham, S, Khaw, Kt, Kesse, E, Tehard, B, CLAVEL CHAPELON, F, Agudo, A, Ardanaz, E, Quiros, Jr, Amiano, P, C., Mg, Tormo, Mj, Pala, V, Panico, Salvatore, Vineis, P, Palli, D, Tumino, R, Trichopoulou, A, Baibas, N, Zilis, D, Hemon, B, Norat, T, Riboli, E, and Kaaks, R.
Subjects: Cancer Research, medicine.medical_treatment, FACTOR (IGF)-I, Body Mass Index, chemistry.chemical_compound, Sex hormone-binding globulin, Sex Hormone-Binding Globulin, Prospective Studies, Insulin-Like Growth Factor I, BINDING PROTEIN-3, anthropometry, biology, C-Peptide, C-peptide, Middle Aged, POLYCYSTIC-OVARY-SYNDROME, sex-steroid hormones, European Prospective Investigation into Cancer and Nutrition, IGF-I, Postmenopause, Oncology, POSTMENOPAUSAL WOMEN, PREMENOPAUSAL WOMEN, Androgens, Female, LIFE-STYLE, ENERGY-BALANCE, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, insulin, medicine.drug_class, Internal medicine, GROWTH-FACTOR-I, medicine, Humans, BREAST-CANCER, ddc:610, business.industry, Waist-Hip Ratio, Insulin, Estrogens, Androgen, BODY-MASS INDEX, Endocrinology, Cross-Sectional Studies, Insulin-Like Growth Factor Binding Protein 3, chemistry, Premenopause, Sex steroid, biology.protein, business, Body mass index, Hormone
Abstract: Objectives: The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).Methods: A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated.Results: BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women.Conclusions: Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens.
Published: 2005

37. Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

Author: Calogero Saieva, Tilman Kühn, Peter M. Nilsson, Brian Buijsse, Anne Tjønneland, Sara Grioni, Eva Ardanaz, Elio Riboli, Françoise Clavel-Chapelon, Sascha Abbas, Sabine Rohrmann, Stephen J. Sharp, Kay-Tee Khaw, Jakob Linseisen, Olov Rolandsson, Timothy J. Key, Guy Fagherazzi, Rosario Tumino, Raul Zamora-Ros, Amalia Mattiello, Nicholas J. Wareham, B. Balkau, Carlotta Sacerdote, Claudia Langenberg, Esther Molina-Montes, Pilar Amiano, Diana Gavrila, Heiner Boeing, Ivonne Sluijs, Rudolf Kaaks, Nadia Slimani, Paul W. Franks, Nita G. Forouhi, Joline W.J. Beulens, Kim Overvad, Annemieke M.W. Spijkerman, J. R. Quirós, University of Zurich, Linseisen, J, Universitat de Barcelona, Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, and APH - Health Behaviors & Chronic Diseases
Subjects: Male, Vitamin, medicine.medical_specialty, Nutritional Status, Medicine (miscellaneous), 610 Medicine & health, Type 2 diabetes, Article, Diabetis no-insulinodependent, Vitamin D, Type 2 Diabetes, Dietary Intake, Observational Study, Epic, Cohort Studies, chemistry.chemical_compound, Risk Factors, Neoplasms, Surveys and Questionnaires, Internal medicine, Vitamin D and neurology, Humans, Medicine, Non-insulin-dependent diabetes, Prospective Studies, ddc:610, Prospective cohort study, Càncer, Proportional Hazards Models, Cancer, Nutrition and Dietetics, business.industry, 2701 Medicine (miscellaneous), 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), Middle Aged, medicine.disease, Obesity, Diet, European Prospective Investigation into Cancer and Nutrition, Europe, Endocrinology, Diabetes Mellitus, Type 2, chemistry, 2916 Nutrition and Dietetics, Female, business, Body mass index, Cohort study
Abstract: Background/Objectives:Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation.Subjects/Methods:Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires.Results:Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend=0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D.Conclusions:This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.European Journal of Clinical Nutrition advance online publication, 20 November 2013; doi:10.1038/ejcn.2013.235.
Published: 2014

38. Consumption of meat and fish and risk of lung cancer: results from the European Prospective Investigation into Cancer and Nutrition

Author: Göran Hallmans, Laudina Rodríguez, Anne Tjønneland, Christina C. Dahm, Antonia Trichopoulou, Annika Steffen, Dagrun Engeset, Bas Bueno-de-Mesquita, Heiner Boeing, Paul Brennan, Rosario Tumino, Antonio Agudo, Isabelle Romieu, Guri Skeie, Kay-Tee Khaw, Jakob Linseisen, Naomi E. Allen, Kim Overvad, Miren Dorronsoro, Torgny Rasmuson, Franco Berrino, Frederike L. Büchner, Nadia Slimani, Anne-Claire Vergnaud, Elio Riboli, José María Huerta, Petra H.M. Peeters, Annekatrin Lukanova, Elisabet Wirfält, Salvatore Panico, Domenico Palli, Eva Ardanaz, Eleni Oikonomou, Rudolf Kaaks, Rikke Egeberg, Jonas Manjer, Paolo Vineis, Nicholas J. Wareham, Timothy J. Key, Michael Katsoulis, Wei W. Xun, Inger T. Gram, Sabine Rohrmann, María José Sánchez, Hendriek C. Boshuizen, University of Zurich, and Linseisen, J
Subjects: Male, Cancer Research, Lung Neoplasms, Nutrition and Disease, recalls, Wiskundige en Statistische Methoden - Biometris, Cohort Studies, Eating, 0302 clinical medicine, Risk Factors, fat, Voeding en Ziekte, 1306 Cancer Research, 030212 general & internal medicine, heme iron, Fishes, cohort, Middle Aged, Nutrition Surveys, PE&RC, heterocyclic amines, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, 030220 oncology & carcinogenesis, Cohort, Red meat, Female, 2730 Oncology, women, Cohort study, Adult, medicine.medical_specialty, Meat, mutagens, White meat, 610 Medicine & health, Adenocarcinoma, 03 medical and health sciences, Environmental health, medicine, Animals, Humans, ddc:610, Risk factor, Lung cancer, Life Style, Mathematical and Statistical Methods - Biometris, dietary habits, Aged, Global Nutrition, Wereldvoeding, business.industry, Feeding Behavior, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), medicine.disease, calibration, mortality, Surgery, Relative risk, business
Abstract: Evidence from case-control studies, but less so from cohort studies, suggests a positive association between meat intake and risk of lung cancer. Therefore, this association was evaluated in the frame of the European Prospective Investigation into Cancer and Nutrition, EPIC. Data from 478,021 participants, recruited from 10 European countries, who completed a dietary questionnaire in 1992-2000 were evaluated; 1,822 incident primary lung cancer cases were included in the present evaluation. Relative risk estimates were calculated for categories of meat intake using multi-variably adjusted Cox proportional hazard models. In addition, the continuous intake variables were calibrated by means of 24-h diet recall data to account for part of the measurement error. There were no consistent associations between meat consumption and the risk of lung cancer. Neither red meat (RR = 1.06, 95% CI 0.89-1.27 per 50 g intake/day; calibrated model) nor processed meat (RR = 1.13, 95% CI 0.95-1.34 per 50 g/day; calibrated model) was significantly related to an increased risk of lung cancer. Also, consumption of white meat and fish was not associated with the risk of lung cancer. These findings do not support the hypothesis that a high intake of red and processed meat is a risk factor for lung cancer.
Published: 2011

39. Diet and hip fractures among elderly Europeans in the EPIC cohort

Author: Ingegerd Johansson, Antonia Trichopoulou, Dimosthenis Zylis, Paolo Boffetta, H. Boeing, Cornelia Weikert, Maria Concetta Giurdanella, J. Linseisen, Philippos Orfanos, Alexandra Nieters, H. B. Bueno-De-Mesquita, R. Tumino, Miren Dorronsoro, P. H. M. Peeters, Paolo Contiero, Ulrika Pettersson, Sabina Sieri, Vassiliki Benetou, Benetou, V., Orfanos, P., Zylis, D., Sieri, S., Contiero, P., Tumino, R., Giurdanella, M.C., Peeters, P.H.M., Linseisen, J., Nieters, A., Boeing, H., Weikert, C., Pettersson, U., Johansson, I., Bueno-De-Mesquita, H.B., Dorronsoro, M., Boffetta, P., and Trichopoulou, A.
Subjects: Male, medicine.medical_specialty, hip, Medicine (miscellaneous), European, elderly, Risk Factors, Surveys and Questionnaires, Vegetables, medicine, Vitamin D and neurology, Humans, hip fractures, diet, nutrients, risk factors, ddc:610, Prospective Studies, Risk factor, Prospective cohort study, Aged, Proportional Hazards Models, Geriatrics, Aged, 80 and over, Hip fracture, Nutrition and Dietetics, business.industry, Hip Fractures, Incidence (epidemiology), Incidence, cohort, Feeding Behavior, Middle Aged, medicine.disease, Surgery, Diet, Europe, Nutrition Assessment, fracture, Cohort, Fatty Acids, Unsaturated, Female, EPIC, business, Demography, Cohort study
Abstract: Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect. © 2011 Macmillan Publishers Limited All rights reserved.
Published: 2010

40. Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)

Author: Beatrice Malmer, Jonas Manjer, Anne Tjønneland, Paolo Vineis, Laudina Rodríguez Suárez, Carlos A. González, Roel Vermeulen, Rosario Tumino, H. Bas Bueno-de-Mesquita, Amalia Mattiello, Paolo Crosignani, Kim Overvad, Aurelio Barricarte, Franco Berrino, Pietro Ferrari, Jakob Linseisen, Ole Raaschou-Nielsen, Elio Riboli, Sheila Bingham, Göran Berglund, Timothy J. Key, Giovanna Masala, Antonia Trichopoulou, Manuela M. Bergmann, Stefano Rosso, Sophia Zackrisson, Heiner Boeing, Kay-Tee Khaw, Göran Hallmans, Nadia Slimani, David Neasham, Kaspar René Nielsen, Ruth C. Travis, Paolo Boffetta, Ahlem Sifi, Carmen Navarro, Rudolf Kaaks, Eiliv Lund, Neasham, D., Sifi, A., Nielsen, K.R., Overvad, K., Raaschou-Nielsen, O., Tjønneland, A., Barricarte, A., González, C.A., Navarro, C., Suarez, L.R., Travis, R.C., Key, T., Linseisen, J., Kaaks, R., Crosignani, P., Berrino, F., Rosso, S., Mattiello, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Berglund, G., Manjer, J., Zackrisson, S., Hallmans, G., Malmer, B., Bingham, S., Khaw, K.T., Bergmann, M.M., Boeing, H., Trichopoulou, A., Masala, G., Tumino, R., Lund, E., Slimani, N., Ferrari, P., Boffetta, P., Vineis, P., and Riboli, E.
Subjects: Adult, Male, medicine.medical_specialty, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, Age Distribution, immune system diseases, Internal medicine, hemic and lymphatic diseases, Occupational Exposure, Epidemiology, medicine, Humans, multicentre prospective cohort study, ddc:610, Risk factor, Occupations, Prospective cohort study, Multiple myeloma, 030304 developmental biology, risk, Aged, 0303 health sciences, Occupation, business.industry, Lymphoma, Non-Hodgkin, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, 3. Good health, Surgery, European Prospective Investigation into Cancer and Nutrition, Europe, Occupational Diseases, 030220 oncology & carcinogenesis, Plasmacytoma, Female, business, EPIC, Epidemiologic Methods, Cohort study
Abstract: ObjectivesEvidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study.MethodsWe investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma.ResultsThe following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6).ConclusionThe findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.
Published: 2010

41. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies

Author: Jonas Manjer, Jone M. Altzibar, Domenico Palli, Vanessa Dumeaux, Jakob Linseisen, Bas Bueno-de-Mesquita, Heiner Boeing, Henning Grønbæk, María José Tormo, Kim Overvad, Mazda Jenab, Kay-Tee Khaw, Ignacio Donate Suárez, Petra H.M. Peeters, Carla H. van Gils, Elio Riboli, Vassiliki Benetou, Tobias Pischon, Salvatore Panico, Françoise Clavel-Chapelon, Anja Olsen, Nadia Slimani, Rosario Tumino, Signe Borgquist, Rebecca J. Cleveland, Aurelio Barricarte Gurrea, Andrew W. Roddam, Paolo Vineis, Marie-Christine Boutron-Ruault, Sabina Rinaldi, Esther Molina, Georgios Makrygiannis, Claudia Agnoli, Carlos González, Teresa Norat, Inger T. Gram, Sabine Rohrmann, Sophie Morois, Paolo Boffetta, Anne Tjønneland, Alina Vrieling, Sheila Bingham, Antonia Trichopoulou, Eiliv Lund, Rudolf Kaaks, Carine Biessy, Naomi E. Allen, Rinaldi, S., Cleveland, R., Norat, T., Biessy, C., Rohrmann, S., Linseisen, J., Boeing, H., Pischon, T., Panico, S., Agnoli, C., Palli, D., Tumino, R., Vineis, P., Peeters, P.H.M., Van Gils, C.H., Bueno-de-Mesquita, B.H., Vrieling, A., Allen, N.E., Roddam, A., Bingham, S., Khaw, K.-T., Manjer, J., Borgquist, S., Dumeaux, V., Gram, I.T., Lund, E., Trichopoulou, A., Makrygiannis, G., Benetou, V., Molina, E., Suárez, I.D., Gurrea, A.B., Gonzalez, C.A., Tormo, M.-J., Altzibar, J.M., Olsen, A., Tjonneland, A., Grønbæk, H., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Slimani, N., Boffetta, P., Jenab, M., Riboli, E., and Kaaks, R.
Subjects: Oncology, Male, Cancer Research, medicine.medical_specialty, EPIC cohort, Colorectal cancer, Colon, Population, Enzyme-Linked Immunosorbent Assay, Cohort Studies, Risk Factors, Internal medicine, medicine, Humans, Prospective Studies, ddc:610, Risk factor, Insulin-Like Growth Factor I, education, Prospective cohort study, Aged, Neoplasm Staging, education.field_of_study, business.industry, Case-control study, Rectum, Cancer, Middle Aged, medicine.disease, Prognosis, Diet, IGF-I, Europe, Insulin-Like Growth Factor Binding Proteins, Survival Rate, meta-analysis, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, IGFBP-3: colorectal cancer, Case-Control Studies, Nested case-control study, Female, business, Colorectal Neoplasms, Cohort study, Follow-Up Studies
Abstract: Udgivelsesdato: 2010-apr-01 Several prospective studies have shown a moderate positive association between increasing circulating insulin-like growth factor-I (IGF-I) levels and colorectal cancer risk. However, the associations were often statistically nonsignificant, and the relationship of cancer risk with IGF-I's major binding protein, IGFBP-3, showed major discrepancies between studies. We investigated the association of colorectal cancer risk with serum IGF-I, total and intact IGFBP-3, in a case-control study nested within the EPIC cohort (1,121 cases of colorectal cancer and 1,121 matched controls). Conditional logistic regression was used to adjust for possible confounders. Our present study results were combined in a meta-analysis with those from 9 previous prospective studies to examine the overall evidence for a relationship of prediagnostic serum IGF-I with colorectal cancer risk. In the EPIC study, serum concentrations of IGF-I and IGFBP-3 showed no associations with risk of colorectal cancer overall. Only in subgroup analyses did our study show moderate positive associations of IGF-I levels with risk, either among younger participants only (and only for colon cancer) or among participants whose milk intakes were in the lowest tertile of the population distribution (RR for an increase of 100 ng/ml = 1.43 [95% CI = 1.13-1.93]). Nevertheless, in the meta-analysis a modest positive association remained between serum IGF-I and colorectal cancer risk overall (RR = 1.07 [1.01-1.14] for 1 standard deviation increase in IGF-I). Overall, data from our present study and previous prospective studies combined indicate a relatively modest association of colorectal cancer risk with serum IGF-I.
Published: 2010

42. Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: Kay-Tee Khaw, Petra H.M. Peeters, Aurelio Barricarte, Esther Molina, Nikolaus Becker, Androniki Naska, Miren Dorronsoro, Vassiliki Benetou, Jonas Manjer, Nadia Slimani, Valeria Pala, Guri Skeie, Ulrika Ericson, Ruth C. Travis, Magritt Brustad, Kim Overvad, Rosario Tumino, Nicholas J. Wareham, Ole Raaschou-Nielsen, Beatrice Melin, Jakob Linseisen, Aneire E. Khan, Paolo Vineis, Giovanna Masala, Paolo Boffetta, Eiliv Lund, H. Bas Bueno-de-Mesquita, Antonia Trichopoulou, Teresa Norat, Heiner Boeing, Anne-Claire Vergnaud, Roel Vermeulen, Sabina Rinaldi, Rudolf Kaaks, Paula Jakszyn, Amalia Mattiello, Marianne Uhre Jakobsen, Marie-Christine Boutron-Ruault, Anne Tjønneland, María José Tormo, Timothy J. Key, Manuela M. Bergmann, Sabine Rohrmann, Marcial Argüelles, University of Zurich, Rohrmann, S, Rohrmann, S., Linseisen, J., Jakobsen, M.U., Overvad, K., Raaschou-Nielsen, O., Tjonneland, A., Boutron-Ruault, M.C., Kaaks, R., Becker, N., Bergmann, M., Boeing, H., Khaw, K.-T., Wareham, N.J., Key, T.J., Travis, R., Benetou, V., Naska, A., Trichopoulou, A., Pala, V., Tumino, R., Masala, G., Mattiello, A., Brustad, M., Lund, E., Skeie, G., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Vermeulen, R.C.H., Jakszyn, P., Dorronsoro, M., Barricarte, A., Tormo, M.-J., Molina, E., Argüelles, M., Melin, B., Ericson, U., Manjer, J., Rinaldi, S., Slimani, N., Boffetta, P., Vergnaud, A.-C., Khan, A., Norat, T., and Vineis, P.
Subjects: Male, Oncology, medicine.medical_specialty, Cancer Research, Lymphoma, B-Cell, Consumption, lymphoma, 610 Medicine & health, Lymphoma, T-Cell, Risk Assessment, Cohort Studies, Food group, meat, Cheese, immune system diseases, Internal medicine, hemic and lymphatic diseases, lymhomas, meat consumption, dairy consumption, cohort study, Humans, Medicine, 1306 Cancer Research, ddc:610, Risk factor, risk, business.industry, Lymphoma, Non-Hodgkin, Cancer, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), European Prospective Investigation into Cancer and Nutrition, Yogurt, medicine.disease, Lymphoma, Europe, Relative risk, Immunology, dairy, Female, 2730 Oncology, Dairy Products, Waldenstrom Macroglobulinemia, business, Risk assessment, Cohort study
Abstract: The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies. Copyright © 2010 UICC.
Published: 2010

43. Weight change in later life and risk of death amongst the elderly: the European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health study

Author: C, Bamia, J, Halkjaer, P, Lagiou, D, Trichopoulos, A, Tjønneland, T L, Berentzen, K, Overvad, F, Clavel-Chapelon, M-C, Boutron-Ruault, S, Rohrmann, J, Linseisen, A, Steffen, H, Boeing, A M, May, P H, Peeters, H, Bas Bueno-de-Mesquita, S W, van den Berg, M, Dorronsoro, A, Barricarte, L, Rodriguez Suarez, C, Navarro, C A, González, P, Boffetta, V, Pala, G, Hallmans, A, Trichopoulou, Bamia, C., Halkjær, J., Lagiou, P., Trichopoulos, D., Tjønneland, A., Berentzen, T.L., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Rohrmann, S., Linseisen, J., Steffen, A., Boeing, H., May, A.M., Peeters, P.H., Bas Bueno-De-Mesquita, H., Van Den Berg, S.W., Dorronsoro, M., Barricarte, A., Rodriguez Suarez, L., Navarro, C., González, C.A., Boffetta, P., Pala, V., Hallmans, G., and Trichopoulou, A.
Subjects: Adult, Male, Anthropometry, Cancer and Nutrition, Weight change, Middle Aged, Prognosis, Weight Gain, elderly, Body Mass Index, Europe, Ageing, Case-Control Studies, Weight Loss, Humans, Female, Obesity, Prospective Studies, ddc:610, Mortality, Aged
Abstract: Udgivelsesdato: 2010-Jan-28 Abstract. Bamia C, Halkjaer J, Lagiou P, Trichopoulos D, Tjønneland A, Berentzen TL, Overvad K, Clavel-Chapelon F, Boutron-Ruault M-C, Rohrmann S, Linseisen J, Steffen A, Boeing H, May AM, Peeters PH, Bas Bueno-de-Mesquita H, van den Berg SW, Dorronsoro M, Barricarte A, Rodriguez Suarez L, Navarro C, González CA, Boffetta P, Pala V, Hallmans G, Trichopoulou A (University of Athens, Athens, Greece; Institute of Cancer Epidemiology, Copenhagen, Denmark; Harvard School of Public Health, Boston, MA, USA; Bureau of Epidemiologic Research, Athens, Greece; Hellenic Health Foundation, Athens, Greece; Institute of Preventive Medicine, Copenhagen, Denmark; Institute of Public Health, Aarhus University, Aarhus, Denmark; Center for Cardiovascular Research, Aalborg, Denmark; Institut Gustave-Roussy, Paris, France; German Cancer Research Centre, Heidelberg, Germany; Institute of Epidemiology, Potsdam, Germany; German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany; University Medical Center Utrecht, Utrecht, the Netherlands; Public Health and Primary Care, London, UK; National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Public Health Department of Gipuzkoa & Ciberesp, San Sebastian, Spain; Health Institute of Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Health and Healthcare services council, Asturias, Spain; Murcia Regional Health Council, Murcia, Spain; Catalan Institute of Oncology, Barcelona, Spain; International Agency for Research on Cancer, Lyon, France; Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy; and Nutritional Research, Umea, Sweden). Weight change in later life and risk of death amongst the elderly: the European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health study. J Intern Med 2010; 000: 000-000. Objective. Later life weight change and mortality amongst elders. Design. Nested case-control study. Setting. Six countries from the European Investigation into Cancer and nutrition - Elderly, Network on Ageing and Health. Subjects. A total of 1712 deceased (cases) and 4942 alive (controls) were selected from 34 239 participants, >/= 60 years at enrolment (1992-2000) who were followed-up until March 2007. Annual weight change was estimated as the weight difference from recruitment to the most distant from-date-of-death re-assessment, divided by the respective time. Outcome measures. Mortality in relation to weight change was examined using conditional logistic regression. Results. Weight loss >1 kg year(-1) was associated with statistically significant increased death risk (OR = 1.65; 95% CI: 1.41-1.92) compared to minimal weight change (+/-1 kg year(-1)). Weight gain >1 kg year(-1) was also associated with increased risk of death (OR = 1.15; 95% CI: 0.98-1.37), but this was evident and statistically significant only amongst overweight/obese (OR = 1.55; 95% CI: 1.17-2.05). In analyses by time interval since weight re-assessment, the association of mortality with weight loss was stronger for the interval proximal (
Published: 2010

44. Alcohol consumption patterns, diet and body weight in 10 European countries

Author: P. Ferrari, Y. T. van der Schouw, Tonje Braaten, M-J Sanchez, H. B. Bueno-de-Mesquita, Françoise Clavel-Chapelon, Salvatore Panico, M-D Chirlaque, Nadia Slimani, M. Bergmann, Majken K. Jensen, Sabina Sieri, Ingegerd Johansson, Diederick E. Grobbee, Carlotta Sacerdote, Peter Wallström, Jakob Linseisen, Christine L. Parr, Sabine Rohrmann, Anne Tjønneland, Calogero Saieva, Vittorio Krogh, A. Olsen, Vardis Dilis, Sheila Bingham, Elio Riboli, Naomi E. Allen, Mazda Jenab, M. Niravong, Y. Chloptsios, Ailsa A Welch, Sieri, S, Krogh, V, Saieva, C, Grobbee, De, Bergmann, M, Rohrmann, S, Tjønneland, A, Ferrari, P, Chloptsios, Y, Dilis, V, Jenab, M, Linseisen, J, Wallström, P, Johansson, I, Chirlaque, Md, Sanchez, Mj, Niravong, M, Clavel Chapelon, F, Welch, Aa, Allen, Ne, Bueno de Mesquita, Hb, van der Schouw, Yt, Sacerdote, C, Panico, Salvatore, Parr, Cl, Braaten, T, Olsen, A, Jensen, Mk, Bingham, S, Riboli, E, and Slimani, N.
Subjects: Gerontology, Adult, Male, Alcohol Drinking, 030309 nutrition & dietetics, Medicine (miscellaneous), Alcohol, Friends, EPIC, Body weight, Diet Surveys, Body Mass Index, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sex Factors, Dietary Sucrose, Environmental health, mental disorders, Dietary Carbohydrates, Medicine, Humans, Mass index, 030212 general & internal medicine, Prospective Studies, ddc:610, Aged, Consumption (economics), 0303 health sciences, Nutrition and Dietetics, Life style, business.industry, Data Collection, Body Weight, Starch, Middle Aged, Dietary Fats, Diet Records, 3. Good health, Diet, Europe, chemistry, Educational Status, Female, Dietary Proteins, business, Energy Intake, Alcohol consumption, Body mass index
Abstract: BACKGROUND/OBJECTIVES: Europe has the highest level of alcohol consumption in the world. As drinking patterns are important determinants of the beneficial and harmful effects of alcohol consumption, we investigated alcohol consumption in relation to nutrient intake, place of consumption, education and body weight in a sample of adults from 10 European countries. METHODS: A 24-h dietary recall interview was conducted on 13 025 men and 23 009 women, aged 35-74 years, from 27 centres participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Means and standard errors of alcohol consumption, adjusted for age, were calculated, stratified by gender and centre. RESULTS: In many centres, higher level drinkers (males consuming >24 g of ethanol/day, equivalent to >2 standard drinks and females consuming >12 g of ethanol/day equivalent to >1 standard drink) obtained more energy from fat and protein and less from sugar than did abstainers. The proportion of energy from starch tended to be higher for male and lower for female higher level drinkers than for abstainers. Female higher level drinkers had a lower body mass index than did abstainers, whereas male higher level drinkers generally weighed more. Male higher level drinkers were less educated than abstainers in Mediterranean countries, but were more educated elsewhere. Female higher level drinkers were usually more educated than were abstainers. Outside the home, consumption (both genders) tended to be at friends' homes, particularly among men in Northern and Central Europe, and in bars in Spain. CONCLUSIONS: This study reveals clear geographical differences in drinking habits across Europe, and shows that the characteristics of different alcohol consumption categories also vary.
Published: 2009

45. Occupational exposures contribute to educational inequalities in lung cancer incidence among men: evidence from the EPIC prospective cohort study

Author: Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton E., Vineis, Paolo, Dalton, Susanne O., Bergmann, Manuela M., Hermann, Silke, Veglia, Fabrizio, Ferrari, Pietro, Overvad, Kim, Raaschou-Nielsen, Ole, Tjønneland, Anne, Kaaks, Rudolf, Linseisen, Jakob, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Rodriguez, Laudina, Agudo, Antonio, Sánchez, Maria-José, Arozena, Jone Miren Altzibar, Cirera, Lluis, Ardanaz, Eva, Bingham, Sheila, Khaw, Kay-Tee, Boffetta, Paolo, Duell, Eric, Slimani, Nadia, Gallo, Valentina, Riboli, Elio, Bueno-de-Mesquita, H. Bas, Menvielle, G., Boshuizen, H., Kunst, A.E., Vineis, P., Dalton, S.O., Bergmann, M.M., Hermann, S., Veglia, F., Ferrari, P., Overvad, K., Raaschou-Nielsen, O., Tjønneland, A., Kaaks, R., Linseisen, J., Palli, D., Krogh, V., Tumino, R., Rodriguez, L., Agudo, A., Sánchez, M.-J., Arozena, J.M.A., Cirera, L., Ardanaz, E., Bingham, S., Khaw, K.-T., Boffetta, P., Duell, E., Slimani, N., Gallo, V., Riboli, E., Bas Bueno-de-Mesquita, H., Public Health, Amsterdam Public Health, and Public and occupational health
Subjects: Male, prospective cohort study, Lung Neoplasms, Incidence, men, educational, Article, Occupational, Cohort Studies, lung cancer, SDG 3 - Good Health and Well-being, Socioeconomic Factors, exposure, inequalitie, Occupational Exposure, incidence, Educational Status, Humans, Prospective Studies, ddc:610, EPIC, Proportional Hazards Models
Abstract: The aim of this study is to investigate to what extent occupational exposures may explain socioeconomic inequalities in lung cancer incidence after adjusting for smoking and dietary factors. Analyses were based on a subsample of the European Prospective Investigation into Cancer and Nutrition (EPIC study), a prospective cohort. The analyses included 703 incident lung cancer cases among men in Denmark, the United Kingdom, Germany, Italy, Spain and Greece. The socioeconomic position was measured using the highest level of education. The estimates of relative indices of inequality (RII) were computed with Cox regression models. We first adjusted for smoking (with detailed information on duration and quantity) and dietary factors (fruits and vegetables consumption) and then for occupational exposures. The exposure to three carcinogens [asbestos, heavy metals and polycyclic aromatic hydrocarbons (PAH)] was analyzed. The occupational exposures explained 14% of the socioeconomic inequalities remaining after adjustment for smoking and fruits and vegetables consumption. The inequalities remained nevertheless statistically significant. The RII decreased from 1.87 (95% CI: 1.36-2.56) to 1.75 (1.27-2.41). The decrease was more pronounced when adjusting for asbestos than for heavy metals or PAH. Analyses by birth cohort suggested an effect of occupational exposures among older men, while due to small number of endpoints, no conclusion could be drawn about the role of occupational exposures in educational inequalities among younger men. Our study revealed that the impact of occupational exposures on socioeconomic inequalities in cancer incidence, rarely studied until now, exists while of modest magnitude. Some authors are partners of Environmental Cancer Risk, Nutrition and Individual Susceptibility, a network of excellence of the European Commission (6FP contract 513943). Antonio Agudo and Paolo Vineis were supported by ECNIS.
Published: 2009

46. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study

Author: Göran Hallmans, Giuseppe Del Giudicce, Carlos Caldas, Eiliv Lund, Francisco Rico, Miren Dorronsoro, Antonio Agudo, Naomi E. Allen, Françoise Clavel-Chapelon, Kim Overvad, Núria Sala, Petra H.M. Peeters, Jakob Linseisen, Rudolf Kaaks, Carmen Martinez, Olof Nyrén, Salvatore Panico, Göran Berglund, H. Bas Bueno-de-Mesquita, Gabriel Capellá, Heiner Boeing, Sheila Bingham, Antonia Trichopoulou, Hendriek C. Boshuizen, Mazda Jenab, Elio Riboli, Gabriele Nagel, Carmen Navarro, Fátima Carneiro, Domenico Palli, Guillem Pera, Henrik Simán, Anne Tjønneland, Mario Plebani, Timothy J. Key, Paolo Vineis, Rosario Tumino, José Ramón Quirós, Mattijs E. Numans, Aurelio Barricarte, Carlos A. González, Franco Berrino, Capellá, G, Pera, G, Sala, N, Agudo, A, Rico, F, Del Giudicce, G, Plebani, M, Palli, D, Boeing, H, Bueno de Mesquita, Hb, Carneiro, F, Berrino, F, Vineis, P, Tumino, R, Panico, Salvatore, Berglund, G, Simán, H, Nyrén, O, Hallmans, G, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, Jr, Allen, N, Key, T, Bingham, S, Caldas, C, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Boshuizen, Hc, Peeters, Ph, Numans, Me, Clavel Chapelon, F, Trichopoulou, A, Lund, E, Jenab, M, Kaaks, R, Riboli, E, and González, C. A.
Subjects: Male, DNA Repair, MICROSATELLITE INSTABILITY, Epidemiology, Atrophic gastritis, Colorectal cancer, Chronic gastritis, HOGG1 SER326CYS POLYMORPHISM, CANCER-RISK, LUNG-CANCER, MICROSATELLITE INSTABILITY, INTESTINAL METAPLASIA, CHINESE POPULATION, HELICOBACTER-PYLORI, GENE POLYMORPHISMS, XPD POLYMORPHISMS, COLORECTAL-CANCER, Gastroenterology, COLORECTAL-CANCER, polymorphism, 0302 clinical medicine, Gene Frequency, Pepsinogen A, Odds Ratio, Prospective Studies, 0303 health sciences, HOGG1 SER326CYS POLYMORPHISM, biology, Intestinal metaplasia, Cardia, General Medicine, Middle Aged, Antibodies, Bacterial, 3. Good health, INTESTINAL METAPLASIA, Europe, 030220 oncology & carcinogenesis, Adenocarcinoma, Biological Markers, Female, Gastritis, medicine.symptom, Adult, Gastritis, Atrophic, Risk, medicine.medical_specialty, CANCER-RISK, macromolecular substances, GENE POLYMORPHISMS, Helicobacter Infections, 03 medical and health sciences, LUNG-CANCER, HELICOBACTER-PYLORI, Stomach Neoplasms, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, ddc:610, 030304 developmental biology, Aged, Xeroderma Pigmentosum Group D Protein, CHINESE POPULATION, Polymorphism, Genetic, Helicobacter pylori, business.industry, XPD POLYMORPHISMS, Gastric carcinoma, Microsatellite instability, medicine.disease, biology.organism_classification, Genes, p53, Case-Control Studies, Chronic Disease, business, Biomarkers, H. pylori, genetic susceptibility, Follow-Up Studies
Abstract: BACKGROUND: The contribution of genetic variation in DNA repair genes to gastric cancer (GC) risk remains essentially unknown. The aim of this study was to explore the relative contribution of DNA repair gene polymorphisms to GC risk and severe chronic atrophic gastritis (SCAG). Method A nested case control study within the EPIC cohort was performed including 246 gastric adenocarcinomas and 1175 matched controls. Controls with SCAG (n = 91), as defined by low pepsinogen A (PGA) levels, and controls with no SCAG (n = 1061) were also compared. Twelve polymorphisms at DNA repair genes (MSH2, MLH1, XRCC1, OGG1 and ERCC2) and TP53 gene were analysed. Antibodies against Helicobacter pylori were measured. RESULTS: No association was observed for any of these polymorphisms with stomach cancer risk. However, ERCC2 K751Q polymorphism was associated with an increased risk for non-cardial neoplasm [odds ratio (OR) = 1.78; 95% confidence interval (CI) 1.02-3.12], being ERCC2 K751Q and D312N polymorphisms associated with the diffuse type. ERCC2 D312N (OR = 2.0; 95% CI 1.09-3.65) and K751Q alleles (OR = 1.82; 95% CI 1.01-3.30) and XRCC1 R399Q (OR = 1.69; 95% CI 1.02-2.79) allele were associated with an increased risk for SCAG. CONCLUSION: Our study supports a role of ERCC2 in non-cardial GC but not in cardial cancer. A concordant result was observed for subjects with low PGA levels. XRCC1 allele was associated also with SCAG. This is the first prospective study suggesting that individual variation in DNA repair may be relevant for gastric carcinogenesis, a finding that will require further confirmation validation in larger independent studies. Some authors are partners of ECNIS Network from the 6FP of the EC.
Published: 2008

47. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

Author: Aurelio Barricarte, J. B.A. Crusius, Eiliv Lund, C. Navarro, G. Del Giudice, J. R. Quirós, P. Ferrari, M. Dorronsoro, Jonas Manjer, Timothy J. Key, S. Rinaldi, Núria Sala, Carmen Martinez, Françoise Clavel-Chapelon, Carlos Caldas, Göran Berglund, Roger Stenling, Göran Hallmans, F. C. Büchner, Domenico Palli, Mario Plebani, H. B. Bueno-de-Mesquita, Rudolf Kaaks, Federico Canzian, P. H. M. Peeters, F. Rico, M. E. Numans, Gabriel Capellá, Fátima Carneiro, Antonia Trichopoulou, Heiner Boeing, A. S. Peña, Naomi E. Allen, Vicki Save, Jakob Linseisen, Valeria Pala, Kim Overvad, S. Binghan, C. A. Gonzalez, Anne Tjønneland, Paolo Vineis, Mazda Jenab, Guillem Pera, Rosario Tumino, Salvatore Panico, Antonio Agudo, Elio Riboli, Crusius, Jb, Canzian, F, Capellá, G, Peña, A, Pera, G, Sala, N, Agudo, A, Rico, F, Del Giudice, G, Palli, D, Plebani, M, Boeing, H, Bueno de Mesquita, Hb, Carneiro, F, Pala, V, Save, Ve, Vineis, P, Tumino, R, Panico, Salvatore, Berglund, G, Manjer, J, Stenling, R, Hallmans, G, Martínez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, Jr, Allen, N, Key, Tj, Binghan, S, Caldas, C, Linseisen, J, Kaaks, R, Overvad, K, Tjønneland, A, Büchner, Fc, Peeters, Ph, Numans, Me, Clavel Chapelon, F, Trichopoulou, A, Lund, E, Jenab, M, Rinaldi, S, Ferrari, P, Riboli, E, González, C. A., University of Groningen, Pathology, General practice, and CCA - Disease profiling
Subjects: Male, PROMOTER, Gastroenterology, cytokine genes, Genotype, Medicine, Prospective Studies, Prospective cohort study, Stomach cancer, Lymphotoxin-alpha, POPULATION, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], biology, Hematology, ASSOCIATION, Middle Aged, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Cytokines, severe chronic atrophic gastritis, Female, INTERLEUKIN-1 POLYMORPHISMS, Adult, medicine.medical_specialty, CARCINOMA, Nutritional Status, Adenocarcinoma, GASTRIC-CANCER, HELICOBACTER-PYLORI, INTERLEUKIN-1 POLYMORPHISMS, CARCINOMA, POPULATION, METAANALYSIS, ASSOCIATION, INDIVIDUALS, PROMOTER, HELICOBACTER-PYLORI, Stomach Neoplasms, Internal medicine, CagA, Humans, Genetic Predisposition to Disease, ddc:610, gastric carcinoma, METAANALYSIS, Aged, Polymorphism, Genetic, business.industry, Tumor Necrosis Factor-alpha, Interleukins, Case-control study, Odds ratio, Helicobacter pylori, biology.organism_classification, medicine.disease, INDIVIDUALS, Haplotypes, Case-Control Studies, Immunology, business, polymorphisms, CHINESE, GASTRIC-CANCER
Abstract: BACKGROUND: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. RESULTS: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). CONCLUSION: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC. Some authors are partners of ECNIS, a network of excellence of the EC (FP6 contract 513943).
Published: 2008

48. Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Rudolf Kaaks, Domenico Palli, Jenny Chang-Claude, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, J. Ramón Quirós, Eva Ardanaz, Elio Riboli, Annekatrin Lukanova, Kim Overvad, Anne E. Cust, Heiner Boeing, Dimitiros Trichopoulos, Guillem Pera, Anja Olsen, H. Bas Bueno-de-Mesquita, Salvatore Panico, Eva Lundin, Mandy Schulz, María José Tormo, Naomi E. Allen, Franco Berrino, Kay-Tee Khaw, Timothy J. Key, Petra H. Lahmann, Rosario Tumino, Anne Tjønneland, Androniki Naska, Laure Dossus, Nerea Larrañaga, Petra H.M. Peeters, Sheila Bingham, Antonia Trichopoulou, Sabina Rinaldi, María José Sánchez, Jakob Linseisen, N. Charlotte Onland-Moret, Allen, Ne, Key, Tj, Dossus, L, Rinaldi, S, Cust, A, Lukanova, A, Peeters, Ph, Onland Moret, Nc, Lahmann, Ph, Berrino, F, Panico, Salvatore, Larrañaga, N, Pera, G, Tormo, Mj, Sánchez, Mj, Ramón Quirós, J, Ardanaz, E, Tjønneland, A, Olsen, A, Chang Claude, J, Linseisen, J, Schulz, M, Boeing, H, Lundin, E, Palli, D, Overvad, K, Clavel Chapelon, F, Boutron Ruault, Mc, Bingham, S, Khaw, Kt, Bueno de Mesquita, Hb, Trichopoulou, A, Trichopoulos, D, Naska, A, Tumino, R, Riboli, E, and Kaaks, R.
Subjects: Cancer Research, Endocrinology, Diabetes and Metabolism, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Sex hormone-binding globulin, Risk Factors, Sex Hormone-Binding Globulin, Odds Ratio, Medicine, Testosterone, Prospective Studies, Gonadal Steroid Hormones, media_common, 0303 health sciences, Estradiol, biology, Dehydroepiandrosterone Sulfate, Incidence, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Postmenopause, Oncology, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, Estrone, media_common.quotation_subject, 03 medical and health sciences, Dehydroepiandrosterone sulfate, Humans, ddc:610, Menstrual cycle, Aged, 030304 developmental biology, Gynecology, business.industry, Endometrial cancer, Androstenedione, Odds ratio, medicine.disease, Endometrial Neoplasms, Premenopause, chemistry, biology.protein, Regular papers, business
Abstract: Udgivelsesdato: 2008-Jun Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition using a nested case-control design of 247 incident endometrial cancer cases and 481 controls, matched on center, menopausal status, age, variables relating to blood collection, and, for premenopausal women, phase of menstrual cycle. Using conditional regression analysis, endometrial cancer risk among postmenopausal women was positively associated with increasing levels of total testosterone, free testosterone, estrone, total estradiol, and free estradiol. The odds ratios (ORs) for the highest versus lowest tertile were 2.66 (95% confidence interval (CI) 1.50-4.72; P=0.002 for a continuous linear trend) for estrone, 2.07 (95% CI 1.20-3.60; P=0.001) for estradiol, and 1.66 (95% CI 0.98-2.82; P=0.001) for free estradiol. For total and free testosterone, ORs for the highest versus lowest tertile were 1.44 (95% CI 0.88-2.36; P=0.05) and 2.05 (95% CI 1.23-3.42; P=0.005) respectively. Androstenedione and dehydroepiandrosterone sulfate were not associated with risk. Sex hormone-binding globulin was significantly inversely associated with risk (OR for the highest versus lowest tertile was 0.57, 95% CI 0.34-0.95; P=0.004). In premenopausal women, serum sex hormone concentrations were not clearly associated with endometrial cancer risk, but numbers were too small to draw firm conclusions. In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women.
Published: 2008

49. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Author: Lenka Foretova, Chu Chen, Eiliv Lund, Pierre Hainaut, Vladimir Bencko, Mario Foglio, Torgny Rasmuson, Wolfgang Ahrens, Vladimir Janout, Lars J. Vatten, George Xinarianos, Hans E. Krokan, Maiken Bratt Elvestad, Lorenzo Simonato, Paolo Vineis, Simon Heath, Adrian Cassidy, Fumihiko Matsuda, Françoise Clavel-Chapelon, Renato Talamini, Anne Boland, Peter Rudnai, Anush Mukeria, Gary J. Macfarlane, Marc Delepine, Franco Merletti, Doris Lechner, Ariana Znaor, Sheila Bingham, Diana Zelenika, Simone Benhamou, Gary E. Goodman, Geoffrey Liu, Hélène Blanché, Dana Mates, Claire M. Healy, Rayjean J. Hung, H. Bas Bueno-de-Mesquita, Neonilia Szeszenia-Dabrowska, Ivo Gut, John K. Field, David Zaridze, Jolanta Lissowska, Triantafillos Liloglou, Carmen Martinez, Frank Skorpen, Kristina Kjærheim, Dimitrios Trichopoulos, Ivana Holcatova, Kristian Hveem, Valerie Gaborieau, Paul Brennan, James McKay, Jakob Linseisen, Pagona Lagiou, Elio Riboli, Eleonora Fabianova, Mia Hashibe, John R. McLaughlin, Antonio Agudo, David I. Conway, Ray Lowry, Paolo Boffetta, Steven A. Narod, Mark Lathrop, School of Public Health, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institute of Carcinogenesis, Russian Cancer Research Centre, Cancer Research Centre, Department of Epidemiology, Institute of Occupational Medicine, The M Sklodowska-Curie Cancer Center, Institute of Oncology, National Institute of Environment Health, Specialized Institute of Hygiene and Epidemiology, Regional Authority of Public Health-Specialized State Health Institute, Institute of Public Health, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Masaryk Memorial Cancer Institute (MMCI), Department of Preventive Medicine [Univ Palacký], Faculty of Medicine and Dentistry [Univ Palacký], Palacky University Olomouc-Palacky University Olomouc, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Roy Castle Lung Cancer Research Programme, University of Liverpool, University of Liverpool-Cancer Research Centre, Cancer Care Ontario, Samuel Lunenfeld Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Women's College Research Institute, University of Toronto, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Nutrition, hormones et cancer: épidémiologie et prévention (E3N), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, Imperial College London, Centre for Nutrition and Health (CVG), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Institute of Community Medicine, University of Tromsø (UiT), Andalusian School of Public Health [Granada], MRC Centrer for Nutritional Epidemiology and Cancer Prevention and Survival, University of Cambridge [UK] (CAM), Department of Radiation Sciences, Oncology, Umeå University, Bremen Institute for Prevention Research and Social Medicine, University of Bremen, INSERM U794, CEPH, Génomes et cancer (GC (FRE2939)), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School [Athens], Harvard School of Public Health, Cancer Epidemiology Unit, Université de Turin, Cancer registry of Norway, University of Oslo (UiO), Institut Català d'Oncologia, Spain Institute of Oncology, University of Aberdeen, Aviano cancer center, Aviano Cancer Center, Department of Environmental Medicine and Public Health, Università degli Studi di Padova = University of Padua (Unipd), University of Newcastle Dental School, University of Newcastle, UK, University of Glasgow Dental School, University of Glasgow, Croatian National Cancer Registry, National Institute of Public Health, Trinity College School of Dental Science, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre d'Etude du Polymorphisme Humain (CEPH), Université Paris Diderot - Paris 7 (UPD7)-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Fondation Jean Dausset, Hung, R.J., McKay, J.D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Chen, C., Goodman, G., Field, J.K., Liloglou, T., Xinarianos, G., Cassidy, A., McLaughlin, J., Liu, G., Narod, S., Krokan, H.E., Skorpen, F., Elvestad, M.B., Hveem, K., Vatten, L., Linseisen, J., Clavel-Chapelon, F., Vineis, P., Bueno-De-Mesquita, H.B., Lund, E., Martinez, C., Bingham, S., Rasmuson, T., Hainaut, P., Riboli, E., Ahrens, W., Benhamou, S., Lagiou, P., Trichopoulos, D., Holcátová, I., Merletti, F., Kjaerheim, K., Agudo, A., MacFarlane, G., Talamini, R., Simonato, L., Lowry, R., Conway, D.I., Znaor, A., Healy, C., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Matsuda, F., Blanche, H., Gut, I., Heath, S., Lathrop, M., Brennan, P., Savelli, Bruno, Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), and Universita degli Studi di Padova
Subjects: Lung Neoplasms, Genotype, Locus (genetics), [SDV.CAN]Life Sciences [q-bio]/Cancer, Receptors, Nicotinic, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Odds Ratio, medicine, Humans, Genetic Predisposition to Disease, ddc:610, nicotinic acetylcholine receptor, Lung cancer, 030304 developmental biology, Chromosomes, Human, Pair 15, 0303 health sciences, Multidisciplinary, CHRNA5, Respiratory disease, Cancer, medicine.disease, Lung cancer susceptibility, 3. Good health, Europe, Protein Subunits, lung cancer, Nicotinic acetylcholine receptor, Nicotinic agonist, 030220 oncology & carcinogenesis, Immunology, biology.protein
Abstract: Letter; International audience; Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually1. To identify genetic factors that modify disease risk, we conducted a genome-wide association study by analysing 317,139 single-nucleotide polymorphisms in 1,989 lung cancer cases and 2,625 controls from six central European countries. We identified a locus in chromosome region 15q25 that was strongly associated with lung cancer (P = 9 × 10$^{-10}$). This locus was replicated in five separate lung cancer studies comprising an additional 2,513 lung cancer cases and 4,752 controls (P = 5 × 10$^{-20}$ overall), and it was found to account for 14% (attributable risk) of lung cancer cases. Statistically similar risks were observed irrespective of smoking status or propensity to smoke tobacco. The association region contains several genes, including three that encode nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3 and CHRNB4). Such subunits are expressed in neurons and other tissues, in particular alveolar epithelial cells, pulmonary neuroendocrine cells and lung cancer cell lines, and they bind to N′-nitrosonornicotine and potential lung carcinogens. A non-synonymous variant of CHRNA5 that induces an amino acid substitution (D398N) at a highly conserved site in the second intracellular loop of the protein is among the markers with the strongest disease associations. Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets
Published: 2008

50. Plasma selenium concentration and prostate cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Steffen Weikert, Nina Føns Johnsen, Domenico Palli, Elio Riboli, Aurelio Barricarte, Rosario Tumino, Sheila Bingham, Rudolf Kaaks, Nadia Slimani, Kim Overvad, Timothy J. Key, Andrew W. Roddam, Antonia Trichopoulou, Laudina Rodríguez, Carlotta Sacerdote, Gesthimani Misirli, Antonio Agudo, Paul N. Appleby, Dimitrios Trichopoulos, Kay-Tee Khaw, María José Tormo, Lambertus A. Kiemeney, Paolo Boffetta, Pär Stattin, H. Bas Bueno-de-Mesquita, María José Sánchez, H. Boeing, Anne Tjønneland, Göran Hallmans, Naomi E. Allen, Sabina Rinaldi, Nerea Larrañaga, Sara Grioni, Jakob Linseisen, Allen, N.E., Appleby, P.N., Roddam, A.W., Tjønneland, A., Johnsen, N.F., Overvad, K., Boeing, H., Weikert, S., Kaaks, R., Linseisen, J., Trichopoulou, A., Misirli, G., Trichopoulos, D., Sacerdote, C., Grioni, S., Palli, D., Tumino, R., Bueno-de-Mesquita, H.B., Kiemeney, L.A., Barricarte, A., Larrañaga, N., Sánchez, M.-J., Agudo, A., Tormo, M.-J., Rodriguez, L., Stattin, P., Hallmans, G., Bingham, S., Khaw, K.-T., Slimani, N., Rinaldi, S., Boffetta, P., Riboli, E., and Key, T.J.
Subjects: Male, Oncology, medicine.medical_specialty, alpha-Tocopherol, Medicine (miscellaneous), chemistry.chemical_element, Aetiology, screening and detection [ONCOL 5], Antioxidants, Molecular epidemiology [NCEBP 1], Cohort Studies, Selenium, Prostate cancer, Translational research [ONCOL 3], Risk Factors, Internal medicine, Determinants in Health and Disease [EBP 1], medicine, Humans, ddc:610, Risk factor, selenium, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], Aged, Neoplasm Staging, Gynecology, gamma-Tocopherol, Nutrition and Dietetics, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Smoking, Case-control study, Prostatic Neoplasms, Cancer, food and beverages, Middle Aged, medicine.disease, prostate cancer, European Prospective Investigation into Cancer and Nutrition, Europe, chemistry, Case-Control Studies, Relative risk, Multivariate Analysis, business, Cohort study
Abstract: Contains fulltext : 71468.pdf (Publisher’s version ) (Closed access) BACKGROUND: Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer. OBJECTIVE: The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors. DESIGN: A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls. RESULTS: Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration. CONCLUSION: Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men.
Published: 2008

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