1. Pre-clinical development of the antibiotic Corallopyronin A
- Author
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Schiefer, A, Krome, A, Kehraus, S, Hübner, M, Hüttel, S, Jansen, R, Pogorevc, D, Schäberle, T, Roth, M, König, GM, Keller, C, Rupp, J, Wagner, K, Müller, R, Stadler, M, Pfarr, K, and Hoerauf, A
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Corallopyronin A (CorA) is a natural product produced by Corallococcuscoralloides that inhibits bacterial DNA-dependent RNA polymerase. Because CorA binds to the switch region and not in the active site, it is active against rifampicin-resistant S. aureus and MRSA. We have shown in vitro and in vivo[for full text, please go to the a.m. URL], Infektiologie Update 2018; 26. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG)
- Published
- 2018
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