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Objective: Freezing of gait (FOG) is among the most common and disabling symptoms of Parkinson's disease (PD). While the efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been proven in large randomized, controlled trials, its effect on FOG is still insufficiently understood. [for full text, please go to the a.m. URL]

Objective: In medical refractory temporal lobe epilepsy (TLE), especially in the absence of clear MRI pathologies and non-specific results from presurgical evaluation, the seizure focus can be difficult to find and thereby difficult to treat. Invasive monitoring with stereoelectroencephalography (sEEG)[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objectives: This study was designed to determine in vivo kinematics of subjects having either a customized, individually made (CIM) posterior cruciate retaining (CR) implant or one of two Off-the-shelf (OTS) CR TKA while performing a deep knee bend (DKB) and during a chair-rise. Methods: Sixty-five[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

Objectives: The objective of this study was to use a state-of-the-art mobile fluoroscopy unit to determine the in vivo kinematics for subjects having a either a traditional, off-the-shelf (OTS) knee implant vs. subjects having a customized, individually made (CIM) knee implant that replicates their [for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)

Objective: Both the surgical approach and the optimal site for deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) for epilepsy are controversial. Method: An extraventricular approach was used for bilateral electrode implantation in general anaesthesia in 14 patients (10 female;[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Objective: To assess adverse events (AE) associated with deep brain stimulation (DBS) in an unselected cohort. Methods: Medical records (694 documents) of 105 consecutive patients (female 44; median age 63 years, range 17–75), who had undergone DBS between 2006 and 2011 were analyzed retrospectively.[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: There is scarce knowledge available about the position of electrodes for deep brain stimulation (DBS) of the posteroventrolateral (PVL) internal pallidum (GPI). Methods: 18 patients (3 male; mean age 42) with dystonia (4 cervical, 5 segmental, 1 axial, 3 generalized, 3 myoclonus), spinocerebellar[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Objective: The effects of intraoperative air collections on brain shift and the precision of stereotactic electrode implantation is a matter of ongoing debate. Methods: In 53 patients electrodes were implanted into the subthalamic nucleus (31), internal pallidum (12), or ventrolateral thalamus (9).[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Objective: Some of the cardinal symptoms of Parkinson's disease (PD) share a pathological rhythmic dysregulation as common feature, indicating a disturbing rhythmicity within cortical and subcortical networks involving the basal ganglia (BG) as well. Deep brain stimulation (DBS) of the subthalamic[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Objective: Awake surgery is regarded as mandatory for optimal electrode implantation into the subthalamic nucleus (STN) for deep brain stimulation (DBS) in Parkinson's disease (PD). However, even in the awake state, clinical testing is limited by e.g. subjective rating, fluctuating/insufficient[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Objective: Changes in neuronal activity are thought to underlie the development of symptoms in neurodegenerative diseases such as Parkinson's disease (PD). Adaptive neuronal responses to therapeutic interventions such as deep brain stimulation (DBS), assessed on the level of gene expression changes[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Objective: Head tremor may be associated with or the predominant symptom of patients with essential tremor (ET) or dystonia (DT). The globus pallidus internus (GPI) and the ventrolateral thalamus/subthalamic region ("VIM") represent competing targets for deep brain stimulation (DBS). [for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Objective: Deep brain stimulation (DBS) modulates the expression of immediate early genes and of genes involved in neurotransmission suggesting down-stream molecular alterations. To our knowledge, no experimental work has been published reporting the effect on gene-expression in distinct brain areas[for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien

Objective: To demonstrate the feasibility of a precise delineation of the subthalamic nucleus (STN) in surgery for Parkinson’s disease (PD) under general anesthesia (GA) with the aid of microelectrode-recordings and to characterize the associated changes in neural activity in the STN and adjacent[for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien