1. Cognitive decline and the PPAR-γ Pro12Ala genotype: variation by sex and ethnicity.
- Author
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WEST, NANCY A., BAXTER, JUDITH, BRYANT, LUCINDA L., and NELSON, TRACY L.
- Subjects
HISPANIC Americans ,WHITE people ,COGNITION disorders ,GENETIC polymorphisms ,INTERVIEWING ,PROBABILITY theory ,PSYCHOLOGICAL tests ,RESEARCH funding ,SEX distribution ,T-test (Statistics) ,MULTIPLE regression analysis ,SECONDARY analysis ,DATA analysis software ,PEROXISOME proliferator-activated receptors ,DESCRIPTIVE statistics ,GENETICS - Abstract
Objective: we investigated the association between the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12Ala polymorphism and cognitive decline in older adults. Methods: participants from a population-based cohort of older Hispanic and non-Hispanic white adults (n = 492) were administered the Mini Mental State Examination (MMSE), a multi-domain cognitive screening tool, and the Behavioral Dyscontrol Scale (BDS), a measure of executive cognitive function, at baseline and at follow-up, an average of 22 months later. Multiple linear regression was used to investigate the association between the two cognitive test scores and the Pro12Ala polymorphism. Results: at baseline, presence of the Ala1 2 allele was not significantly associated with MMSE score (P = 0.62) nor with BDS score (P = 0.85). Heterogeneity was present for cognitive decline as measured by the MMSE among ethnic, sex and Ala12 allele status (P = 0.04 for three-way interaction term). Stratification by the cross-classification of sex and ethnicity revealed significantly greater declines in MMSE score among male Hispanic carriers of the Ala1 2 allele compared to male Hispanic non-carriers (decline = 4.0 versus 1.6 points; P = 0.02). A significant difference in decline between Ala12 carriers and non-carriers was not present among the other sex/ethnic groups. Conclusions: carriers of the PPAR-γ Ala1 2 allele showed greater cognitive decline compared to non-carriers as detected by the MMSE but the risk varied across sex and ethnic groups. Male Ala1 2 carriers of Hispanic origin may be a high-risk group for cognitive decline. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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