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Phytochemical study on the aerial parts ofAnemone taipaiensisfor the first time led to the isolation of two new oleanane-type triterpenoid saponins1and2, together with four known saponins (3–6). Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Saponins2–4exhibited cytotoxicity against human glioblastoma U251MG cell line with IC50values ranging from 1.56 to 80.62 μM. [ABSTRACT FROM PUBLISHER]

Abstract: Investigation of the n-BuOH extract of the rhizomes of Anemone taipaiensis led to the isolation of five new oleanane-type triterpenoid saponins (1–5), together with seven known saponins (6–12). Their structures were determined by the extensive use of 1D and 2D NMR experiments along with ESIMS analyses and acid hydrolysis. The aglycone of 1, 2 and 4 was determined as siaresinolic acid, which was reported in this genus for the first time. The cytotoxicities of the saponins 1–12, prosapogenins 4a, 5a, 10a–12a and sapogenins siaresinolic acid (SA), oleanolic acid (OA), hederagenin (HE) were evaluated against five human cancer cell lines, including HepG2, HL-60, A549, HeLa and U87MG. The monodesmosidic saponins 6–8, 5a, 10a–12a and sapogenins SA, OA, HE exhibited cytotoxic activity toward all cancer cell lines, with IC50 values ranging from 2.25 to 57.28μM. Remarkably, the bisdesmosidic saponins 1–4 and 9 showed selective cytotoxicity against the U87MG cells. [Copyright &y& Elsevier]

Abstract: Four new diterpenoids (1,4,5,9), together with 7 known diterpenoids (2,3,6–8,10,11), were isolated from the roots to Euphorbia fischeriana. On the basis of 1D and 2D NMR, HR-ESI-MS spectroscopic analysis, structures of the new compounds were elucidated as 11β-hydroxy-8,14-epoxy-ent-abieta-13(15)-en-16,12-olide (1), 3,20-dihydroxy-ent-1(10), 15-rosadiene (4), 3,7-dihydroxy-ent-1(10), 15-rosadiene (5), ingenol 6,7-epoxy-3- tetradecanoate (9). The compounds isolated were evaluated for their cytotoxicity against four cancer cell lines (A549, BEL7402, HCT116, and MDA-MB-231). Three ingenol diterpenoids (9–11) showed significant cytotoxicity against A549 with IC50 value of 3.35, 2.85, 2.88μg/mL, respectively. [Copyright &y& Elsevier]