1. Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents.
- Author
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Samaan, Nawras, Zhong, Qiu, Fernandez, Jayjoel, Chen, Guanglin, Hussain, Ali M., Zheng, Shilong, Wang, Guangdi, and Chen, Qiao-Hong
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AROMATIC compounds , *ANTINEOPLASTIC agents , *CURCUMIN , *PROSTATE cancer treatment , *CELL-mediated cytotoxicity , *ANDROGENS , *METASTASIS , *THERAPEUTICS - Abstract
Abstract: To improve the potential of curcumin to treat advanced hormone-refractory prostate cancer, three series (A–C) of heteroaromatic analogs (thirty two compounds) with different monoketone linkers have been synthesized and evaluated for cytotoxicity against two human androgen-independent prostate cancer cell lines (PC-3 and DU-145). Among them, thirty analogs are more potent than curcumin against PC-3 cells, and twenty one analogs are more cytotoxic towards DU-145 cells relative to curcumin. The most potent compounds (44, 45, 51, and 52) also showed impressive cytotoxicity against three other metastatic cancer cell lines (MDA-MB-231, HeLa, and A549), with IC50 values ranging from 50 nM to 390 nM. All four most potent analogs exhibited no apparent cytotoxicity towards the MCF-10A normal mammary epithelial cells. Taken together, selective enhancement of cell death in prostate cancer cell lines and other aggressive cancer cell lines suggests that nitrogen-containing heteroaromatic rings are promising bioisosteres of the substituted phenyl ring in curcumin. [Copyright &y& Elsevier]
- Published
- 2014
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