1. Biocompatibility of Modified Bionanocellulose and Porous Poly(ϵ-caprolactone) Biomaterials.
- Author
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Grobelski, Bartlomiej, Wach, RadoslawA., Adamus, Agnieszka, Olejnik, AlicjaK., Kowalska-Ludwicka, Karolina, Kolodziejczyk, Marek, Bielecki, Stanislaw, Rosiak, JanuszM., and Pasieka, Zbigniew
- Subjects
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BIOCOMPATIBILITY , *CELLULOSE , *POROUS materials , *POLYCAPROLACTONE , *BIOMATERIALS , *CELL-mediated cytotoxicity , *FIBROBLASTS - Abstract
Biocompatibility of modified bionanocellulose (BC) and porous poly(ϵ caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observedin vitro.In vivostudy, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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