1. Regulation of the natural killer cell response to interferon-alpha by biogenic amines.
- Author
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Hellstrand K, Kylefjord H, Asea A, and Hermodsson S
- Subjects
- Cell Adhesion drug effects, Cell Communication physiology, Cell Separation, Centrifugation, Density Gradient, Drug Synergism, Humans, Phenotype, Recombinant Proteins, T-Lymphocytes, Tumor Cells, Cultured, Cytotoxicity, Immunologic drug effects, Histamine pharmacology, Interferon Type I pharmacology, Killer Cells, Natural drug effects, Monocytes physiology, Serotonin pharmacology
- Abstract
Monocytes, recovered from human peripheral blood by counter-current centrifugal elutriation (CCE), suppressed baseline natural killer (NK) cell cytotoxicity (NKCC) and rendered NK cells resistant to activation of cytotoxicity by human recombinant interferon-alpha (IFN-alpha) by a cell contact-dependent mechanism. Monocyte-induced suppression of resting and IFN-activated NK cells was abrogated by the biogenic amines histamine [via H2-type receptors (H2R)] and serotonin [via 5-HT1A-type receptors (5-HT1AR)]. Our data are suggestive of a monocyte/NK cell interaction that is subject to regulation by biogenic amines.
- Published
- 1992
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