1. VEXAS Syndrome: Histiocytoid Cells With Feathery Cytoplasm as a Clue to the Diagnosis.
- Author
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Ko CJ, Odell I, Gehlhausen JR, Leventhal J, McNiff JM, and Zubek A
- Subjects
- Humans, Male, Genetic Diseases, X-Linked diagnosis, Genetic Diseases, X-Linked pathology, Genetic Diseases, X-Linked genetics, Female, Biopsy, Vacuoles pathology, Cytoplasm pathology, Cytoplasm metabolism, Histiocytes pathology, Ubiquitin-Activating Enzymes genetics, Ubiquitin-Activating Enzymes metabolism
- Abstract
VEXAS (Vacuoles, E1-ubiquitin activating enzyme UBA1 variant, X-linked, Autoinflammatory, Somatic) syndrome was initially described as having mature neutrophil-predominant infiltrates. More recent reports suggest that infiltrates can be composed of variable cell types. We report three cases of VEXAS syndrome with seven total biopsies having in common histiocytoid cells with feathery cytoplasm; these cells may be a potential clue to the diagnosis., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2025
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