1. Immune Cell Status and Cytokines Profiles in Patients with Acute Retinal Necrosis.
- Author
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Zhang P, Liu S, Wang Z, Zhou M, Jiang R, Xu G, and Chang Q
- Subjects
- Aged, Aqueous Humor immunology, Case-Control Studies, Complement C3 immunology, Complement C4 immunology, Cross-Sectional Studies, Cytomegalovirus Infections immunology, Cytomegalovirus Infections virology, Eye Infections, Viral immunology, Eye Infections, Viral virology, Female, Flow Cytometry, Herpes Zoster Ophthalmicus immunology, Herpes Zoster Ophthalmicus virology, Humans, Immunity, Cellular, Immunoglobulin G blood, Immunoglobulin M blood, Male, Middle Aged, Nephelometry and Turbidimetry, Retinal Necrosis Syndrome, Acute virology, Cytokines metabolism, Retinal Necrosis Syndrome, Acute immunology, T-Lymphocytes, Helper-Inducer immunology
- Abstract
Purpose : To assess the immune status of acute retinal necrosis (ARN) patients and to investigate the immune cell types involved in the immunopathogenesis. Methods : Peripheral blood and intraocular fluid were collected from 17 ARN patients and 9 control subjects. The Percentage of immune cells was measured using flow cytometry, levels of complement and antibodies were determined by rate nephelometry, and cytokine levels in the serum and aqueous humor (AH) were detected using cytokine quantitative chips. Data were analyzed using SPSS 23.0. p < .05 was considered statistically significant. Results : Proportion of T-helper 17 cells ( p = .034) in serum and concentrations of multiple cytokines associated with Th17 cells (IL-6, IL-17, IL-17 F, IL-21, IL-22) in AH and serum were elevated of ARN patients. Conclusion : Th17 cells appeared to participate in the development of ARN. We found inflammatory cytokines and cells were elevated in the serum and AH of ARN patients.
- Published
- 2021
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