1. [Pharmacological correction of Th1 and Th2 lymphocyte activity and cytokine profile in ethanol intoxicated rats].
- Author
-
Zabrodskiĭ PF, Svistunov AA, Lim VG, Grishin VA, Kuz'min AV, and Smurov AV
- Subjects
- Alcoholic Intoxication immunology, Animals, Central Nervous System Depressants pharmacology, Cytokines immunology, Ethanol pharmacology, Female, Immunity, Cellular drug effects, Immunity, Humoral drug effects, Male, Rats, Th1 Cells immunology, Th2 Cells immunology, Alcoholic Intoxication blood, Central Nervous System Depressants adverse effects, Cytokines blood, Ethanol adverse effects, Piperazines pharmacology, Polymers pharmacology, Th1 Cells metabolism, Th2 Cells metabolism
- Abstract
It was established in experiments on noninbred rats that their ethanol intoxication (13 days; total dose, 2.6 LD50) significantly reduces the concentration of blood cytokines IFNgamma, IL-2, IL-4, IL-10, increases the concentration of IL-6, suppresses the immune responses, and reduces the interrelation IFNgamma/IL-4 in comparison to the control, which testifies to the greater damage of Th1 cells in comparison to Th2 lymphocytes. The immunomodulator polyoxidonium administered for four days at a daily dose of 700 microg/kg fully restores the cellular and humoral immune responses and the synthesis of cytokines IFNgamma, IL-2, and IL-4 and partly restores the production of IL-10.
- Published
- 2010