1. Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study
- Author
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Angelo, H. D., Gomes Silva, I. I. F., Oliveira, R. D. R., Louzada Júnior, P., Donadi, E. A., Maia, M. M. D., de Souza, P. R. E., Sandrin Garcia, P., CROVELLA, SERGIO, Angelo, H. D., Gomes Silva, I. I. F., Oliveira, R. D. R., Louzada Júnior, P., Donadi, E. A., Crovella, Sergio, Maia, M. M. D., de Souza, P. R. E., and Sandrin Garcia, P.
- Subjects
Adult ,Male ,Risk ,Immunology ,Gene Expression ,Pilot Projects ,Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,Arthritis, Rheumatoid ,Interferon-gamma ,Gene Frequency ,Rheumatoid ,Genetics ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,Polymorphism ,Cytokine ,Alleles ,Interleukin-12 Subunit p40 ,Arthritis ,Interleukin-18 ,Cytokines ,Middle Aged ,Case-Control Studies ,Female ,Brazil ,Polymorphism, Restriction Fragment Length ,Arthriti - Abstract
Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P
- Published
- 2015