1. From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets.
- Author
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Dang VD, Hilgenberg E, Ries S, Shen P, and Fillatreau S
- Subjects
- Animals, B-Lymphocytes cytology, Cytokines biosynthesis, Humans, Nitric Oxide Synthase Type II immunology, Plasma Cells cytology, Trypanosoma cruzi immunology, B-Lymphocytes immunology, Cell Differentiation, Cytokines immunology, Plasma Cells immunology
- Abstract
B lymphocytes have a unique role as antibody-producing cells. Antibodies are key mediators of humoral immunity against infections, and are thought to account for the protection afforded by successful vaccines. B cells can also secrete cytokines and subsequently regulate immune responses mediated by T and innate cells. Remarkably, recent studies identified plasma blasts/plasma cells as the main types of activated B cells producing the cytokines interleukin (IL)-10, IL-35, tumor necrosis factor (TNF)-α, IL-17, and GM-CSF in various contexts in mice. Here, we discuss these observations, which suggest the existence of various subsets of plasma blast/plasma cells distinguishable through their cytokine expression pattern., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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