1. An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases.
- Author
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Filgueira LM, Cervantes JB, Lovelle OA, Herrera C, Figueredo C, Caballero JA, Sánchez N, Berrio J, Lorenzo G, Cepeda M, Ramos M, Saavedra D, Añe-Kouri AL, Mazorra Z, Leon K, Crombet T, and Caballero A
- Subjects
- Aged, 80 and over, Biomarkers blood, COVID-19 pathology, Critical Illness, Cytokine Release Syndrome pathology, Drug Therapy, Combination, Female, Humans, Interleukin-6 blood, Male, Middle Aged, SARS-CoV-2, Treatment Outcome, Anti-Inflammatory Agents therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Antigens, CD immunology, Antigens, Differentiation, T-Lymphocyte immunology, Cytokine Release Syndrome drug therapy, COVID-19 Drug Treatment
- Abstract
In COVID-19, the inflammatory cytokine-release syndrome is associated with the progression of the disease. Itolizumab is a monoclonal antibody that recognizes human CD6 expressed in activated T cells. The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis. Its effect is associated with the reduction of pro-inflammatory cytokines release, including IFN-γ, IL-6 and TNF-α. Here, we report the outcome of three severe and critically ill COVID-19 patients treated with itolizumab as part of an expanded access protocol. Itolizumab was able to reduce IL-6 concentrations in all the patients. Two of the three patients showed respiratory and radiological improvement and were fully recovered. We hypothesize this anti-inflammatory therapy in addition to antiviral and anticoagulant therapy could reduce COVID-19 associated morbidity and mortality.
- Published
- 2021
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