5 results on '"Vandenbussche C"'
Search Results
2. Pancreaticobiliary Cytology Practice in 2021: Results of a College of American Pathologists Survey.
- Author
-
Li Z, Tabbara SO, Nwosu A, Souers RJ, Goyal A, Kurian EM, Lin X, VandenBussche C, and Nguyen LN
- Subjects
- Humans, Biliary Tract pathology, Biliary Tract cytology, Biopsy, Fine-Needle methods, Pancreas pathology, Pancreatic Neoplasms pathology, Pancreatic Neoplasms diagnosis, Pathology, Clinical methods, Practice Patterns, Physicians' statistics & numerical data, Societies, Medical, Surveys and Questionnaires, United States, Cytodiagnosis methods, Pathologists
- Abstract
Context.—: The College of American Pathologists (CAP) surveys provide national benchmarks of pathology practice., Objective.—: To investigate pancreaticobiliary cytology practice in domestic and international laboratories in 2021., Design.—: We analyzed data from the CAP Pancreaticobiliary Cytology Practice Supplemental Questionnaire that was distributed to laboratories participating in the 2021 CAP Nongynecologic Cytopathology Education Program., Results.—: Ninety-three percent (567 of 612) of respondent laboratories routinely evaluated pancreaticobiliary cytology specimens. Biliary brushing (85%) was the most common pancreaticobiliary cytology specimen evaluated, followed by pancreatic fine-needle aspiration (79%). The most used sampling methods reported by 235 laboratories were 22-gauge needle for fine-needle aspiration (62%) and SharkCore needle for fine-needle biopsy (27%). Cell block was the most used slide preparation method (76%), followed by liquid-based cytology (59%) for pancreatic cystic lesions. Up to 95% (303 of 320) of laboratories performed rapid on-site evaluation (ROSE) on pancreatic solid lesions, while 56% (180 of 320) performed ROSE for cystic lesions. Thirty-six percent (193 of 530) of laboratories used the Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology in 2021. Among all institution types, significant differences in specimen volume, specimen type, ROSE practice, and case sign-out were identified. Additionally, significant differences in specimen type, slide preparation, and ROSE practice were found., Conclusions.—: This is the first survey from the CAP to investigate pancreaticobiliary cytology practice. The findings reveal significant differences among institution types and between domestic and international laboratories. These data provide a baseline for future studies in a variety of practice settings., Competing Interests: The authors are or were members of the College of American Pathologists Cytopathology Committee. Nwosu and Souers are employees of the College of American Pathologists., (© 2024 College of American Pathologists.)
- Published
- 2024
- Full Text
- View/download PDF
3. The fine needle aspiration of translocation sarcomas.
- Author
-
VandenBussche CJ, Adams CL, McDonald OG, Whitworth SA, and Ali SZ
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Retrospective Studies, Sarcoma classification, Sarcoma pathology, Biopsy, Fine-Needle, Cytodiagnosis, Sarcoma diagnosis
- Abstract
Introduction: Soft tissue sarcomas comprise a heterogeneous group of clinically aggressive cancers that are often hard to classify on limited cytological samples. "Translocation sarcomas" (TS) are a diverse subset of such cancers, different from pleomorphic sarcomas, and characterised by unique single chromosomal translocations in each sarcoma subtype. Interestingly, despite their high-grade biological behaviour, TS have deceptively monotonous and bland cytomorphology, therefore creating diagnostic issues on limited samples., Materials and Methods: A retrospective search was conducted of the cytopathology archives of The Johns Hopkins Hospital revealing 147 translocation sarcoma cases over a 25-year period., Results: The common morphological denominators for most translocation sarcomas were: hypercellularity, cellular monotony, mostly discohesive and single cells, round-to-oval or short spindled cells and a lack of necrosis. The exceptions were an inflammatory myofibroblastic tumour, in which cellular monotony was not present owing to the prominence of lymphocytes and plasma cells, and low-grade fibromyxoid sarcoma, in which the specimens were generally hypocellular. Ancillary testing, especially immunoperoxidase staining, was often required for primary lesions., Conclusion: Distinct morphological clues and subsequent ancillary testing (particularly immunoperoxidase staining) provide an accurate diagnosis on cytological interpretation of both, primary and recurrent/metastatic lesions., (© 2017 John Wiley & Sons Ltd.)
- Published
- 2017
- Full Text
- View/download PDF
4. A review of the Paris system for reporting urinary cytology.
- Author
-
VandenBussche CJ
- Subjects
- Humans, Urinary Tract cytology, Cytodiagnosis methods, Disease Notification methods, Urinary Bladder Neoplasms diagnosis, Urinary Bladder Neoplasms pathology, Urinary Tract pathology
- Abstract
After the 2013 International Congress of Cytology in Paris, consensus groups were formed to establish an international reporting system for urinary tract (UT) specimens. The recommended guidelines, known as The Paris System (TPS) for Reporting Urinary Cytology, focus on reducing the rate of unnecessary indeterminate diagnoses while maintaining the excellent performance UT cytology has for identifying high-grade urothelial carcinoma. This review highlights the major features of TPS., (© 2016 John Wiley & Sons Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
5. Analytical validity of a microRNA-based assay for diagnosing indeterminate thyroid FNA smears from routinely prepared cytology slides
- Author
-
Zdenek Kolar, Hila Benjamin, Eti Meiri, Fabio Pagni, Alexander Shtabsky, Syed Z. Ali, Temima Schnitzer-Perlman, Dganit Bar, Christopher J. VandenBussche, Benjamin, H, Schnitzer Perlman, T, Shtabsky, A, Vandenbussche, C, Ali, S, Kolar, Z, Pagni, F, Bar, D, and Meiri, E
- Subjects
0301 basic medicine ,Thyroid nodules ,Cancer Research ,medicine.medical_specialty ,Pathology ,nodule ,smears ,Cytodiagnosis ,Concordance ,Biopsy, Fine-Needle ,fine‐needle aspiration (FNA) ,Papanicolaou stain ,Carcinoma, Papillary, Follicular ,Validation Studies as Topic ,Stain ,Specimen Handling ,thyroid ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,Humans ,Medicine ,Sampling (medicine) ,Thyroid Neoplasms ,Thyroid Nodule ,fine-needle aspiration (FNA) ,Thyroid Epithelial Cells ,microRNA ,business.industry ,Thyroid ,smear ,Reproducibility of Results ,indeterminate ,Original Articles ,Prognosis ,medicine.disease ,molecular test ,MicroRNAs ,030104 developmental biology ,medicine.anatomical_structure ,Molecular Diagnostic Techniques ,Oncology ,Cytopathology ,030220 oncology & carcinogenesis ,Original Article ,Radiology ,business ,nodules - Abstract
BACKGROUND The majority of thyroid nodules are diagnosed using fine‐needle aspiration (FNA) biopsies. The authors recently described the clinical validation of a molecular microRNA‐based assay, RosettaGX Reveal, which can diagnose thyroid nodules as benign or suspicious using a single stained FNA smear. This paper describes the analytical validation of the assay. METHODS More than 800 FNA slides were tested, including slides stained with Romanowsky‐type and Papanicolaou stains. The assay was examined for the following features: intranodule concordance, effect of stain type, minimal acceptable RNA amounts, performance on low numbers of thyroid cells, effect of time since sampling, and analytical sensitivity, specificity, and reproducibility. RESULTS The assay can be run on FNA slides for which as little as 1% of the cells are thyroid epithelial cells or from which only 5 ng of RNA have been extracted. Samples composed entirely of blood failed quality control and were not classified. Stain type did not affect performance. All slides were stored at room temperature. However, the length of time between FNA sampling and processing did not affect assay performance. There was a high level of concordance between laboratories (96%), and the concordance for slides created from the same FNA pass was 93%. CONCLUSIONS The microRNA‐based assay was robust to various physical processing conditions and to differing sample characteristics. Given the assay's performance, robustness, and use of routinely prepared FNA slides, it has the potential to provide valuable aid for physicians in the diagnosis of thyroid nodules. Cancer Cytopathol 2016;124:711–21. © 2016 Rosetta Genomics. Cancer Cytopathology published by Wiley Periodicals, Inc. on behalf of American Cancer Society., Analytical validation of a novel molecular assay for the diagnosis of thyroid nodules with indeterminate cytology using stained fine‐needle aspiration smears is described. The results demonstrate the assay's robustness to various physical processing conditions.
- Published
- 2016
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.