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Your search keyword '"Yoshimura, Yuya"' showing total 3 results
Start Over Author "Yoshimura, Yuya" Topic cytochrome c
3 results on '"Yoshimura, Yuya"'

1. S-15176 and its methylated derivative suppress the CsA-insensitive mitochondrial permeability transition and subsequent cytochrome c release induced by silver ion, and show weak protonophoric activity

Author

Kawashima, Satoshi, Yamamoto, Takenori, Horiuchi, Yuka, Fujiwara, Kengo, Gouda, Shunichi, Yoshimura, Yuya, Yamamoto, Atsushi, Inotani, Yuki, Yamashita, Kikuji, Kitamura, Seiichiro, Terada, Hiroshi, Kanematsu, Makoto, Shishido, Kozo, and Shinohara, Yasuo

Published
2011
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3. Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions

Author

Yamada, Akiko, Yamamoto, Takenori, Yoshimura, Yuya, Gouda, Shunichi, Kawashima, Satoshi, Yamazaki, Naoshi, Yamashita, Kikuji, Kataoka, Masatoshi, Nagata, Toshihiko, Terada, Hiroshi, Pfeiffer, Douglas R., and Shinohara, Yasuo

Subjects
*PERMEABILITY, *CALCIUM ions, *MITOCHONDRIA, *YEAST, *PHOSPHATES, *APOPTOSIS, *CYTOCHROME c
Abstract

Yeast mitochondria have generally been believed not to undergo the permeability transition (PT) by the accumulation of Ca2+ within the mitochondrial matrix, unlike mammalian mitochondria. However, the reason why the yeast PT is not induced by Ca2+ has remained obscure. In this study, we examined in detail the effects of Ca2+ on yeast mitochondria under various conditions. As a result, we discovered that the PT could be induced even in yeast mitochondria by externally added Ca2+ under optimized experimental conditions. The 2 essential parameters for proper observation of the PT-inducing effects of Ca2+ were the concentrations of the respiratory substrate and that of inorganic phosphate (Pi) in the incubation medium. The yeast mitochondrial PT induced by Ca2+ was found to be insensitive to cyclosporin A and suppressed in the presence of a high concentration of Pi. Furthermore, when the PT was induced in yeast mitochondria by Ca2+, the release of cytochrome c from mitochondria was also observed. [Copyright &y& Elsevier]

Published
2009
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