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Objective To assess the evolution of nutritional status and dietary intake in a group of patients with cystic fibrosis (CF) after implementation of a systematic nutritional approach. Methods Prospective study with 39 patients followed in a CF center in Lisbon. All data were collected in two different timepoints: T 0 (2012) and T2 (2014). We recorded demographic and clinical data: sex, age, genotype, pancreatic and pulmonary function; anthropometric parameters: weight, height and body mass index (BMI); dietary intake was assessed by 24 h recall. Statistical analysis: IBM®SPSS®22. Results Thirty-nine patients were included; 53.8% were male; age 10.0±4.5 y in T0 and 11.0±4.5 y in T2. The most common genotype was DF508 homozygotic (76.9%); 92.3% had pancreatic insufficiency. FEV1 decreased from 88.9±22.9% (T0) to 85.9±24.5% (T2). According to BMI, 23.1% (T0) and 20.5% (T2) had underweight, 61.5% (T0) and 69.2% (T2) were eutrophic and 15.4% (T0) and 10.3% (T2) had excess weight. A positive correlation between FEV1 and z-score of BMI was found in both evaluation moments (T0: r = 0.530, p = 0.002; T2: r = 0.463, p = 0.007). Regarding dietary intake, patients consumed 1987 kcal in T0 and 2436 kcal in T2 and 19% protein, 47.4% carbohydrates and 31.9% fats in T0 and 17.8% protein, 43.9% carbohydrates and 32.1% fats in T2. Percentage of patients with nutritional supplementation decreased from 51.3% in T 0 to 35.9% in T 2 . The nutritional status of our sample had a significant improvement due to a structured nutritional approach, since there was a decrease in the prevalence of under and over nutrition. Additionally we observed a decrease of the prescription of nutritional supplements without impact on the nutritional status and dietary intake. [ABSTRACT FROM AUTHOR]