Search

Your search keyword '"Li, Lian-da"' showing total 3 results
Start Over Author "Li, Lian-da" Topic cycloparaffins
3 results on '"Li, Lian-da"'

1. [Effects of series of Muskone on heart hemodynamics and myocardial consumption of oxygen in experimental dogs].

Author

Zhang YT, Ma K, Zhang JY, Li YK, Wu LM, Li XR, Pan L, Gao HL, and Li LD

Subjects
Animals, Aristolochia chemistry, Asteraceae chemistry, Blood Pressure drug effects, Coronary Circulation drug effects, Cycloparaffins isolation & purification, Dogs, Drug Combinations, Female, Heart physiology, Inula chemistry, Male, Myocardium metabolism, Plant Roots chemistry, Plants, Medicinal chemistry, Vascular Resistance drug effects, Cycloparaffins pharmacology, Heart drug effects, Hemodynamics drug effects, Oxygen Consumption drug effects
Abstract

Objective: To observe the effects of series of Muskone (the muskone includes Slender Dutchmanspipe Root, Inula Root and neither kind of Common Aucklandia Root) on the heart hemodynamics and myocardial consumption of oxygen in experimental dogs, and to explain its pharmacological action on cardiovascular system., Method: Arterial blood pressure, coronary blood flow, resistance in coronary artery, total peripheral resistance, work of left artrium and oxygen consumption index of the cardiac muscles were observed in anaesthetic dogs., Result: The series of Muskone decreased arterial blood pressure significantly, dilated coronary artery and peripheral arteries significantly, increased coronary blood flow, decreased resistance in coronary artery, improved the work of left artrium, the oxygen availability of cardiac muscles and the complaisance of arteries in cardiac muscles.

Published
2007

2. [Study on therapeutic effects of series of muskone on myocardial infarction canines].

Author

Zhang JY, Ma K, Li Yk, Zhang YT, Wu LM, Li XR, Pan L, and Li LD

Subjects
6-Ketoprostaglandin F1 alpha blood, Animals, Cycloparaffins isolation & purification, Dogs, Drug Combinations, Drugs, Chinese Herbal isolation & purification, Endothelins blood, Female, Male, Myocardial Infarction blood, Myocardial Infarction pathology, Myocardium pathology, Plants, Medicinal chemistry, Thromboxane B2 blood, Aristolochia chemistry, Cycloparaffins pharmacology, Drugs, Chinese Herbal pharmacology, Inula chemistry, Myocardial Infarction drug therapy
Abstract

Objective: To observe the effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on myocardial ischemia, myocardial infarction and hematological index in experimental canines, and to explain the pharmacological action and characteristic of its therapeutic effect on ischemic heart disease., Method: The range and degree of myocardial ischemia was evaluated by epicardial electrogram mapping, and the range extent of myocardial infarction was determined by quantitate histology (N-BT staining method). Meanwhile, the changes of ET, TXB2, 6-Keto-PGF1alpha were determined to study the effects of the series of Muskone on myocardial ischemia, myocardial infarction and hematological index in experimental canines., Result: The series of Muskone can improve myocardial ischemia and infarction in experimental canines, and relieve significantly the degree of myocardial ischemia (Sigma-ST) determined by epicardial electrogram mapping, decrease the range of myocardial ischemia (N-ST) determined by epicardial electrogram mapping and decrease infarction zone determined by N-BT staining method. And it has a significant inhibition on activity of ET induced by myocardial ischemia and infarction, and increases 6-Keto-PGF1alpha and 6-Keto-PGF1alpha/TXB2 induced by myocardial ischemia., Conclusion: The series of Muskone has significant therapeutic effect on myocardial infarction.

Published
2006

3. [Study on comparative pharmacology of series of Muskone].

Author

Ma K, Zhang JY, Li YK, Zhang YT, Wu LM, Li XR, Pan L, and Li LD

Subjects
6-Ketoprostaglandin F1 alpha blood, Animals, Cycloparaffins isolation & purification, Drug Combinations, Drugs, Chinese Herbal isolation & purification, Endothelins blood, Female, Male, Mice, Mice, Inbred ICR, Pain physiopathology, Plants, Medicinal chemistry, Rats, Rats, Wistar, Thromboxane B2 blood, Aristolochia chemistry, Cycloparaffins pharmacology, Drugs, Chinese Herbal pharmacology, Inula chemistry, Myocardial Infarction drug therapy
Abstract

Objective: To study the therapeutic effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on experimental myocardial infarct and pain in rats., Method: Coronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6- keto-PGF1alpha and TXB2. Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain., Result: The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats, the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1alpha, the ratio of 6-keto-PGF1alpha and TXB2. Single Radix Aristolociae or Radix Inulae only relieved pain., Conclusion: The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristolociae or Radix Inulae only can relieve pain.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results