1. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.
- Author
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Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, Hooshmand SM, Brais LK, Lawrence MS, Pugh T, McKenna A, Sivachenko A, Cibulskis K, Carter SL, Ojesina AI, Freeman S, Jones RT, Voet D, Saksena G, Auclair D, Onofrio R, Shefler E, Sougnez C, Grimsby J, Green L, Lennon N, Meyer T, Caplin M, Chung DC, Beutler AS, Ogino S, Thirlwell C, Shivdasani R, Asa SL, Harris CR, Getz G, Kulke M, and Meyerson M
- Subjects
- Cell Cycle genetics, Cohort Studies, Genes, Tumor Suppressor, Genetic Predisposition to Disease, Humans, Intestinal Neoplasms epidemiology, Intestinal Neoplasms pathology, Intestine, Small pathology, Neuroendocrine Tumors epidemiology, Neuroendocrine Tumors pathology, Sequence Analysis, DNA, Cyclin-Dependent Kinase Inhibitor p27 genetics, Intestinal Neoplasms genetics, Mutation, Neuroendocrine Tumors genetics
- Abstract
The diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not yet been defined. Using exome- and genome-sequence analysis of SI-NETs, we identified recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27. We observed frameshift mutations of CDKN1B in 14 of 180 SI-NETs, and we detected hemizygous deletions encompassing CDKN1B in 7 out of 50 SI-NETs, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs.
- Published
- 2013
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