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Objective: CX3CL1 played an important role in atherosclerosis recently. We investigated the association between the chemokine CX3CL1 with coronary artery disease in type 2 diabetes mellitus. Methods: CX3CL1 expression in carotid artery specimens was analysed by immunohistochemistry. The study was conducted in 400 coronary artery disease in type 2 diabetes mellitus and 400 control subjects in a case-control study. CX3CL1 gene rs170364 variant was detected by the directing sequencing technology. Results: CX3CL1 expressions were increased markedly in carotid artery plaque than in normal carotid artery. CX3CL1 gene rs170364 genotype (GG, GT and TT) frequency in coronary artery disease in type 2 diabetes mellitus is 42.7%, 40.0% and 17.2%, and 50.2%, 39.6% and 10.2% in the control group. CX3CL1 gene rs170364 variant is a genetic risk factor for coronary artery disease in type 2 diabetes mellitus (P <0.05). Logistic regression analysis with adjustments for other risk factors showed that the CX3CL1 gene rs170364 T allele significantly increases the risk of coronary artery disease in type 2 diabetes mellitus compared with the control subjects (P <0.05). Conclusion: Our study shows that the CX3CL1 expression increased in the carotid plaques and serum of the coronary artery disease in type 2 diabetes mellitus. CX3CL1 gene rs170364 variant may be considered a genetic risk factor for coronary artery disease in type 2diabetes mellitus. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical significance of serum CX3CL1 level for coronary artery disease. Methods: The study was conducted in 250 cases of coronary artery disease patients(75 patients with stable angina pectoria,75 patients with unstable angina pectoris,50 patients with ST-elevation acute myocardial infarction,50 non ST-elevation acute myocardial infarction patients) and 200 cases of control subjects(normal coronay artery) in a case-control study. The CX3CL1 level in different groups were analyzed by ELISA and CX3CR1 expression on CD4~+CD28~-T cells was analyzed by flow cytometry. Results: The serum CX3CL1 level increased markedly in coronary artery disease patients compared with the control subjects(P<0.05). The serum CX3CL1 level of patients with stable unstable angina was increased in the patients with ST-elevation acute myocardial infarction than those with the non ST-elevation acute myocardial infarction patients(P<0.05). An increased number of CD4~+CD28~-CX3CR1+T cells was found in the patients with coronary artery disease patients than the control group especially in the ST-elevation acute myocardial infarction patient(P<0.05). Conclusion: CX3CL1 might be involved in the formation of coronary atherosclerotic plaque and played an important role in the atherosclerotic procession,which might be useful to predict the stability of plaque in the early stage of coronary artery disease. [ABSTRACT FROM AUTHOR]

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