Titanium and its alloys are associated with low density and excellent strength/weight ratio, biocompatibility in surgical implants, high mechanical strength at high temperatures and excellent corrosion resistance. The Ti6Al4V alloy is applied in the aerospace, biomedical, chemical, naval and petrochemical industries. However, these alloys present problems during machining and are therefore considered materials of difficult machinability at high cutting speeds. This paper aims to analyse the wear mechanisms in cutting tools using cemented carbide (H13A) and synthetic polycrystalline diamond (PCD) in the high-speed turning of Ti6Al4V alloy, under the following cooling conditions: dry, jet and minimum quantity lubricant (MQL). To measure wear, a microscope was used to measure flank wear in the tools. Next, the images of these tools were obtained using scanning electron microscopy for the identification of the wear mechanisms. According to the results, the variation in the cutting parameters (cutting speed and feed rate), type of tool material, as well as the cooling conditions significantly affects the behaviour of the wear mechanisms. The wear mechanisms presented in the cutting tools are not the result of one single mechanism, but a combination of many mechanisms. Overall, the primary type of wear is flank wear and the mechanisms are abrasion, adhesion and attrition (adherence and drag). [ABSTRACT FROM AUTHOR]