1. A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS.
- Author
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Huang Y, Tian R, Hu W, Jia Y, Zhang J, Jiang H, and Zhang L
- Subjects
- Administration, Oral, Adsorption, Animals, Biological Availability, Capsules, Curcumin chemistry, Curcumin pharmacokinetics, Hydrogen-Ion Concentration, Lactose chemistry, Male, Organ Specificity, Pectins chemistry, Rats, Rats, Sprague-Dawley, Solubility, Tablets, Colon metabolism, Curcumin administration & dosage, Drug Delivery Systems methods
- Abstract
This study developed and evaluated a colon-specific pulsatile capsule with tablet of self-microemulsifying drug delivery system (SMEDDS). This system is based on an impermeable capsule containing a rapid-disintegrating curcumin-loaded SMEDDS tablet inside it, and a highly methoxylated pectin (H-pectin)/lactose tablet plugged in the capsule mouth. The SMEDDS tablet enhanced the solubility of curcumin, a water-insoluble drug. An in vitro release study of the pulsatile capsule showed a typical pulsatile release profile with a specific lag time. The lag time, which determines the efficiency of colon-specific delivery, could be regulated by varying the H-pectin/lactose ratio. Pectinase and rat cecal contents added to the release medium significantly shortened the erosion time, which proved that the H-pectin plug is sensitive to enzyme degradation. These results show that the pulsatile capsule with SMEDDS tablet has potential for the colon-specific delivery of water-insoluble drugs., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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