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The homeostatic control of Sodium (Na + ) ion in the human body assumes paramount relevance owing to its physiological importance. Any deviation from the normal level causes serious health problems like hypernatremia, hyponatremia, stroke, kidney problems etc. Therefore, quantification of Na + levels in body fluids has significant diagnostic and prognostic importance. However, interfering ions like Potassium ion (K + ) is the major hurdle in sodium detection. In this work, we synthesized the clusters of 3-9 nm-sized highly stable and pure Copper nanoparticles surface functionalised with curcumin, through chemical reduction method. Each cluster of particles is encapsulated in a curcumin layer which is clearly visible in TEM images. The results show that these curcumin functionalized Cu NPs (CuC) are highly selective to the colorimetric detection of Na + . The ions like K + , Mg 2+ and Zn 2+ did not interfere with the Na + in this sensing technique. Low-cost paper-based sensor strips are fabricated and calibrated for the sensing of sodium in the physiological range and shade cards were developed as a calorimetric guide for estimation of Na + which makes them ideal point of care diagnostic platform. We demonstrate that the proposed CuC paper strip can be used for detecting Na + concentration within the whole physiological range in both blood serum and urine., (© 2022. The Author(s).)