1. Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides.
- Author
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Tu WC, Qi YY, Ding LF, Yang H, Liu JX, Peng LY, Song LD, Gong X, Wu XD, and Zhao QS
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Crystallography, X-Ray, Diterpenes chemistry, Diterpenes isolation & purification, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HeLa Cells, Humans, Models, Molecular, Molecular Conformation, Sesquiterpenes chemistry, Sesquiterpenes isolation & purification, Structure-Activity Relationship, Antineoplastic Agents, Phytogenic pharmacology, Cupressaceae chemistry, Diterpenes pharmacology, Plant Bark chemistry, Plant Stems chemistry, Sesquiterpenes pharmacology
- Abstract
A phytochemical study on the stem bark of Metasequoia glyptostroboides led to the isolation of sixty-one diterpenoids and sesquiterpenoids, including seventeen previously undescribed compounds, metaglyptins A-Q. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, and
1 H,13 C and 2D NMR). The absolute configurations of metaglyptins I, J, and O were determined by the ECD data and single-crystal X-ray diffraction analysis. The undescribed compounds were evaluated for their cytotoxicity against HeLa, AGS, and MDA-MB-231 cancer cell lines. The results revealed that metaglyptin A exhibited moderate cytotoxicity against MDA-MB-231 cell line with IC50 value of 20.02 μM., (Copyright © 2019 Elsevier Ltd. All rights reserved.)- Published
- 2019
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