1. Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients.
- Author
-
Zaragoza, R., Pemán, J., Quindós, G., Iruretagoyena, J. R., Cuétara, M. S., Ramírez, P., D Gómez, M., Camarena, J. J., Viudes, A., and Pontón, J.
- Subjects
- *
CANDIDA albicans , *IMMUNOGLOBULINS , *INTENSIVE care units , *CRYPTOCOCCACEAE , *CANDIDA - Abstract
The present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine the clinical significance and influence on mortality of Candida albicans germ tube-specific antibodies (CAGTA). There were 22 patients (41.5%) for whom the CAGTA results were positive, although none of had a blood culture positive for Candida. The intra-ICU mortality rate was significantly lower (p = 0.004) in CAGTA-positive patients (61.2% vs. 22.7%). Multivariate analysis confirmed that a positive CAGTA result was the only protective factor to be independently associated with ICU mortality (β coefficient = −0.3856; 95% confidence interval = −0.648 to −0.123). [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF