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Acrylamide polymers with a high degree of polymerization are widely used in petroleum production. It is of great significance to study the oil displacement mechanism of acrylamide polymers with a high degree of polymerization from the micro level. In recent years, the rapid development of computer molecular simulation technology has filed the gaps in macroscopic experiments and theories. This technology has been highly valued in the study of the molecular behaviour of polymer systems. In this paper, the research progress of molecular simulation applied to high-polymerization-degree acrylamide polymer is summarized. The application status of acrylamide polymer flooding, the analysis of polymer flooding mechanisms, and the research progress of molecular simulation in acrylamide linear and crosslinked polymers are expounded. Finally, the development prospect of acrylamide polymer research is given, and suggestions are put forward in terms of simulation direction and simulation tools. [ABSTRACT FROM AUTHOR]