Search

Your search keyword '"Maciel, Wirlaine Glauce"' showing total 3 results
Start Over Author "Maciel, Wirlaine Glauce" Topic cross infection
3 results on '"Maciel, Wirlaine Glauce"'

1. Multidrug-resistant Acinetobacter baumannii outbreaks: a global problem in healthcare settings.

Author

Kurihara MNL, Sales RO, Silva KED, Maciel WG, and Simionatto S

Subjects
Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Delivery of Health Care, Disease Outbreaks, Drug Resistance, Multiple, Bacterial, Humans, Acinetobacter Infections drug therapy, Acinetobacter Infections epidemiology, Acinetobacter baumannii, Cross Infection drug therapy, Cross Infection epidemiology
Abstract

Introduction: The increase in the prevalence of multidrug-resistant Acinetobacter baumannii infections in hospital settings has rapidly emerged worldwide as a serious health problem., Methods: This review synthetizes the epidemiology of multidrug-resistant A. baumannii, highlighting resistance mechanisms., Conclusions: Understanding the genetic mechanisms of resistance as well as the associated risk factors is critical to develop and implement adequate measures to control and prevent acquisition of nosocomial infections, especially in an intensive care unit setting.

Published
2020
Full Text
View/download PDF

2. A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit.

Author

da Silva KE, Maciel WG, Croda J, Cayô R, Ramos AC, de Sales RO, Kurihara MNL, Vasconcelos NG, Gales AC, and Simionatto S

Subjects
Acinetobacter Infections drug therapy, Acinetobacter Infections microbiology, Acinetobacter baumannii drug effects, Acinetobacter baumannii physiology, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Bacterial Proteins genetics, Brazil epidemiology, Case-Control Studies, Cross Infection drug therapy, Cross Infection microbiology, Drug Resistance, Multiple, Bacterial genetics, Female, Humans, Intensive Care Units statistics & numerical data, Male, Microbial Sensitivity Tests, Middle Aged, beta-Lactamases genetics, Acinetobacter Infections mortality, Acinetobacter baumannii isolation & purification, Anti-Bacterial Agents pharmacology, Cross Infection mortality, Hospital Mortality
Abstract

The global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) strains has restricted the therapeutic options available to treat infections due to this pathogen. Understanding the prevalence of such infections and the underlying genetic mechanisms of resistance may help in the implementation of adequate measures to control and prevent acquisition of nosocomial infections, especially in an intensive care unit setting. This study describes the molecular characteristics and risk factors associated with OXA-23-producing A. baumannii infections. A case-control study was undertaken from September/2013 to April/2015. Acquisition of OXA-23-producing A. baumannii was found to be associated with the use of nasogastric tubes, haemodialysis, and the use of cephalosporins. These isolates were only susceptible to amikacin, gentamicin, tigecycline, and colistin, and contained the ISAba1 insertion sequence upstream ofblaOXA-23 and blaOXA-51 genes. Twenty-six OXA-23-producing A. baumannii strains belonged to the ST79 (CC79) clonal group,and patients infected or colonised by these isolates had a higher mortality rate (34.6%). In conclusion, this study showed a dissemination of OXA-23-producing A. baumannii strains that was associated with several healthcare-related risk factors and high mortality rates among intensive care unit patients., Competing Interests: A.C.G. has recently received research funding and/or consultation fees from Bayer, MSD, and Pfizer. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors have nothing to declare.

Published
2018
Full Text
View/download PDF

3. Identification of São Paulo metallo-beta-lactamase-1-producing Pseudomonas aeruginosa in the Central-West region of Brazil: a case study.

Author

Maciel WG, Silva KE, Bampi JV, Bet GM, Ramos AC, Gales AC, and Simionatto S

Subjects
Brazil, Fatal Outcome, Humans, Male, Middle Aged, Pseudomonas aeruginosa isolation & purification, Cross Infection microbiology, Pseudomonas Infections microbiology, Pseudomonas aeruginosa enzymology, beta-Lactam Resistance, beta-Lactamases biosynthesis
Abstract

Metallo-beta-lactamase production is an important mechanism for carbapenem resistance of Pseudomonas aeruginosa , which represents an emerging public health challenge. We report the case of a patient admitted to an intensive care unit, with sepsis caused by multidrug-resistant São Paulo Metallo-beta-lactamase-1-producing P. aeruginosa . This is the first case of infection by this pathogenic strain in the State of Mato Grosso do Sul, Brazil. Thus, infection control measures are required for preventing future spread and outbreaks.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results