10 results on '"Li, Xuehua"'
Search Results
2. CT-based radiomics signature of visceral adipose tissue and bowel lesions for identifying patients with Crohn’s disease resistant to infliximab
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Wang, Yangdi, Luo, Zixin, Zhou, Zhengran, Zhong, Yingkui, Zhang, Ruonan, Shen, Xiaodi, Huang, Lili, He, Weitao, Lin, Jinjiang, Fang, Jiayu, Huang, Qiapeng, Wang, Haipeng, Zhang, Zhuya, Mao, Ren, Feng, Shi-Ting, Li, Xuehua, Huang, Bingsheng, Li, Zhoulei, Zhang, Jian, and Chen, Zhihui more...
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- 2024
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3. Comparative analysis of [18F]F-FAPI PET/CT, [18F]F-FDG PET/CT and magnetization transfer MR imaging to detect intestinal fibrosis in Crohn’s disease: A prospective animal model and human cohort study
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Li, Zhoulei, Chen, Zhihui, Zhang, Ruonan, Lin, Jinjiang, Huang, Siyun, Shi, Kuangyu, Shen, Xiaodi, Xiang, Zijun, Wang, Xinyue, Huang, Lili, Zheng, Qingzhu, Liu, Xubin, Tan, Jinyu, Chen, Minhu, Li, Ziping, Mao, Ren, Zhang, Xiangsong, Wang, Yangdi, Song, Xinming, and Li, Xuehua more...
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- 2024
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4. Comparative analysis of [18F]F-FAPI PET/CT, [18F]F-FDG PET/CT and magnetization transfer MR imaging to detect intestinal fibrosis in Crohn's disease: A prospective animal model and human cohort study.
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Li, Zhoulei, Chen, Zhihui, Zhang, Ruonan, Lin, Jinjiang, Huang, Siyun, Shi, Kuangyu, Shen, Xiaodi, Xiang, Zijun, Wang, Xinyue, Huang, Lili, Zheng, Qingzhu, Liu, Xubin, Tan, Jinyu, Chen, Minhu, Li, Ziping, Mao, Ren, Zhang, Xiangsong, Wang, Yangdi, Song, Xinming, and Li, Xuehua more...
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POSITRON emission tomography ,CROHN'S disease ,MAGNETIZATION transfer ,MAGNETIC resonance imaging ,FIBROSIS ,NO-tillage - Abstract
Purpose: Accurately and early detection of intestinal fibrosis in Crohn's disease (CD) is crucial for clinical management yet remains an unmet need. Fibroblast activation protein inhibitor (FAPI) PET/CT has emerged as a promising tool to assess fibrosis. We aimed to investigate the diagnostic capability of [
18 F]F-FAPI PET/CT in detecting intestinal fibrosis and compared it with[18 F]F-FDG PET/CT and magnetization transfer MR imaging (MTI). Methods: Twenty-two rats underwent TNBS treatment to simulate fibrosis development, followed by three quantitative imaging sessions within one week. Mean and maximum standardized uptake values (SUVmean and SUVmax ) were calculated on[18 F]F-FAPI and [18 F]F-FDG PET/CT, along with normalized magnetization transfer ratio on MTI. Intestinal fibrosis was assessed pathologically, with MTI serving as imaging standard for fibrosis. The diagnostic efficacy of imaging parameters in fibrosis was compared using pathological and imaging standards. Ten patients with 34 bowel strictures were prospectively recruited to validate their diagnostic performance, using the identical imaging protocol. Results: In CD patients, the accuracy of FAPI uptake (both AUCs = 0.87, both P ≤ 0.01) in distinguishing non-to-mild from moderate-to-severe fibrosis was higher than FDG uptake (both AUCs = 0.82, P ≤ 0.01) and comparable to MTI (AUCs = 0.90, P ≤ 0.001). In rats, FAPI uptake responded earlier to fibrosis development than FDG and MTI; consistently, during early phase, FAPI uptake showed a stronger correlation (SUVmean : R = 0.69) with pathological fibrosis than FDG (SUVmean : R = 0.17) and MTI (R = 0.52). Conclusion: The diagnostic efficacy of [18 F]F-FAPI PET/CT in detecting CD fibrosis is superior to [18 F]F-FDG PET/CT and comparable to MTI, exhibiting great potential for early detection of intestinal fibrosis. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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5. Validation of disease severity index for predicting complicated disease in Crohn's disease: A comparison study with Lémann index.
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Qiu, Yun, Zhou, Longyuan, Lu, Baolan, Lin, Xiaoqing, Chen, Baili, He, Yao, Zeng, Zhirong, Chen, Minhu, Li, Xuehua, and Mao, Ren
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Disease Severity Index (DSI) provides comprehensive assessment of bowel damage (BD). To evaluate DSI in patients with Crohn's disease (CD) at high risk of disease progression, compared to Lémann Index (LI). Patients with CD in our center were reviewed consecutively between 2017 and 2019. DSI, LI, and complicated CD course were analyzed. The median LI and DSI of included 300 patients were 1.63 (IQR 1.25–3.13) and 42 (IQR 32–51), respectively. 152 patients (50.7%) experienced a complicated disease course (median 5.1 months; IQR 1.1–20.2). DSI (AUC 0.66; 95% CI 0.60–0.72) better predicted a complicated course of CD over LI (AUC 0.56; 95% CI 0.50–0.63; P = 0.007). The cumulative probability of complicated CD course in severe patients was higher than those with 'mild CD' (P < 0.001). The Cox analysis identified DSI>43 (HR 2.18; 95% CI 1.54–3.09; P < 0.001), B2/3 vs. B1 (HR 2.80; 95% CI 1.99–3.94; P < 0.001), and a higher level of CRP (HR 1.01; 95% CI 1.00–1.02; P = 0.005) as independent prognostic factors for complicated CD. However, LI was not associated with complicated CD (P = 0.164). Higher DSI was associated with complicated disease outcomes. DSI might play a better role than LI in identifying patients at high risks of disease progression. [ABSTRACT FROM AUTHOR] more...
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- 2024
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6. Early transmural healing and its predictors assessed by magnetic resonance enterography in patients with Crohn's disease receiving ustekinumab.
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Zhou, Longyuan, Hu, Cicong, Zhang, Ruonan, Qiu, Yun, Wang, Yu, Liu, Zishan, Chen, Baili, He, Yao, Zeng, Zhirong, Li, Xuehua, Mao, Ren, and Chen, Minhu
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CROHN'S disease ,MAGNETIC resonance ,HEALING ,SMALL intestine - Abstract
Background: Transmural healing (TH) is a potential therapeutic goal of Crohn's disease (CD) and is associated with better clinical outcomes. However, few studies have described early TH and its predictors. Objectives: We aimed to evaluate early TH and its predictors using magnetic resonance enterography (MRE) in patients with CD receiving ustekinumab (UST). Design: This was a retrospective observational study. Methods: Patients with active CD treated with UST and their intestinal segments with bowel wall thickness (BWT) ⩽ 3 mm at baseline were included. Clinical characteristics, laboratory indicators, endoscopic manifestations, and MRE indices were evaluated at baseline and week 26 (W26) of the therapy. The following MRE parameters were assessed: BWT, edema, apparent diffusion coefficient (ADC), Clermont score, Magnetic Resonance Index of Activity score, fat stranding, comb sign, and stricture. TH was defined as BWT ⩽ 3 mm without any signs of inflammation (i.e., ulceration, edema, diffusion-weighted hyperintensity, and increased contrast enhancement) at W26. Results: The study included 37 patients with 106 intestinal segments (including 15 proximal small intestines, 33 terminal ilea, and 58 colons). Clinical features, laboratory indicators, endoscopic results, and MRE parameters at W26 were significantly improved after UST treatment in both patient-based and intestinal segment-based analysis. Seven (18.9%) patients and 26 (24.5%) intestinal segments achieved TH at W26. Baseline BWT [odds ratio (OR) = 0.287, 95% confidence interval (CI), 0.090–0.918, p = 0.035] and ADC (OR = 2.997, 95% CI, 1.009–8.908, p = 0.048) predict TH of patients at W26. Baseline ADC (OR = 2.857, 95% CI, 1.285–6.349, p = 0.010) and presence of stenosis (OR = 0.196, 95% CI, 0.052–0.735, p = 0.016) were associated with TH of segments at W26. Conclusion: Early TH assessed by MRE was observed in nearly one-fifth of patients with CD and intestinal segments after UST treatment for 26 weeks. Baseline MRE indices such as BWT and presence of stenosis might negatively predict TH, while ADC might positively predict early TH. [ABSTRACT FROM AUTHOR] more...
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- 2023
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7. Identifying patients with Crohn's disease at high risk of primary nonresponse to infliximab using a radiomic‐clinical model.
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Li, Xuehua, Zhong, Yingkui, Yuan, Chenglang, Lin, Jinjiang, Shen, Xiaodi, Guo, Minyi, Lu, Baolan, Meng, Jixin, Wang, Yangdi, Zhang, Naiwen, Luo, Zixin, Hu, Guimeng, Mao, Ren, Chen, Minhu, Sun, Canhui, Li, Ziping, Cao, Qing‐hua, Chen, Baili, Chen, Zhihui, and Huang, Bingsheng more...
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CROHN'S disease ,RECEIVER operating characteristic curves ,FEATURE extraction ,INFLIXIMAB ,BODY mass index - Abstract
Approximately 13%–40% of patients with Crohn's disease (CD) show a primary loss of response to infliximab (IFX) therapy. Therefore, differentiating potential responders from primary nonresponders is clinically important. In this double‐center study, we developed and validated a computed tomography enterography (CTE)‐based radiomic signature (RS) for identification of CD patients at high risk of primary nonresponse (PNR) to IFX therapy, and demonstrated its incremental value to the clinical model. A total of 244 patients (training cohort, n = 119; test cohort 1, n = 51; test cohort 2, n = 74) were retrospectively recruited. Their clinical data and pretreatment CTE were retrieved and analyzed. All patients underwent IFX induction therapy. Reliability of clinical factors and radiomic‐based features were assessed with the area under the receiver operating characteristic curve (AUC). In all, 1130 radiomic features were extracted from the whole inflamed gut in CTE images. In training cohort and test cohorts 1 and 2, the RS that discriminated PNR to IFX therapy yielded AUCs of 0.848, 0.789, and 0.789, respectively (all p < 0.05). By combining the clinical predictors (C‐reactive protein, albumin, and body mass index) and RS, the radiomic‐clinical model showed an increase in predicting performance (AUCs: 0.864, 0.794, and 0.791, respectively; all p < 0.05). Decision curve analysis and net reclassification improvement demonstrated the clinical usefulness of the radiomic‐clinical model. In this study, the proposed RS showed potential as a clinical aid for the accurate identification of CD patients at high risk of PNR to IFX therapy before treatment. A combination of the RS and existing clinical factors might enable a step forward precise medicine. [ABSTRACT FROM AUTHOR] more...
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- 2022
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8. Mesenteric abnormalities play an important role in grading intestinal fibrosis in patients with Crohn's disease: a computed tomography and clinical marker-based nomogram.
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Meng, Jixin, Mao, Yitao, Zhou, Jie, Chen, Zhao, Huang, Siyun, Wang, Yangdi, Huang, Li, Zhang, Ruonan, Shen, Xiaodi, Lv, Wen, Xiao, Juxiong, Ye, Ziyin, Chen, Zhihui, Mao, Ren, Sun, Canhui, Li, Ziping, Feng, Shi-Ting, Lin, Shaochun, and Li, Xuehua more...
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CROHN'S disease ,COMPUTED tomography ,RECEIVER operating characteristic curves ,NOMOGRAPHY (Mathematics) ,FIBROSIS ,TUMOR grading ,LIVER histology - Abstract
Background: While the grading of intestinal fibrosis is closely related to the therapeutic strategy of patients with Crohn's disease (CD), it has not yet been well resolved. Mesenteric abnormalities are inextricably linked to intestinal fibrosis. Objectives: We aimed to establish an optimal model for assessing intestinal fibrosis using computed tomography enterography (CTE) and clinical markers. Design: A total of 174 patients with CD between January 2014 and June 2020 were included in this retrospective multicentre study. Methods: All patients underwent CTE within 3 months prior to surgery. Intestinal fibrosis was pathologically scored as non-mild or moderate-to-severe. Selected imaging of the intestinal walls and mesentery and/or clinical factors were used to develop the diagnostic models. The area under the receiver operating characteristic curve (AUC) analysis was used to evaluate the discrimination performance of the models. A decision curve analysis was performed to evaluate the clinical usefulness of the models. Results: One-, two-, and three-variable models were identified as possible diagnostic models. Model 1 [mesenteric creeping fat index (MCFI)], Model 2 (mesenteric oedema and MCFI), and Model 3 (mesenteric oedema, MCFI, and disease duration) were established. The AUCs of Model 1 in training and test cohorts 1 and 2 were 0.799, 0.859, and 0.693, respectively; Model 2 was 0.851, 0.833, and 0.757, respectively; and Model 3 was 0.832, 0.821, and 0.850, respectively. We did not observe any significant difference in diagnostic performance between the training and total test cohorts in any model (all p > 0.05). The decision curves showed that Model 3 had the highest net clinical benefit in test cohort 2. The nomogram of this optimal model was constructed by considering the favourable and robust performance of Model 3. Conclusion: A nomogram integrating mesenteric abnormalities on CTE with a clinical marker was optimal for differentiating between non-mild and moderate-to-severe fibrosis in patients with CD. [ABSTRACT FROM AUTHOR] more...
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- 2022
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9. Native T 1 Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn's Disease: A Comparative Animal Study.
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Lu, Baolan, Lin, Jinjiang, Du, Jinfang, He, Shaofu, Cao, Qinghua, Huang, Li, Mao, Ren, Sun, Canhui, Li, Ziping, Feng, Shiting, and Li, Xuehua
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MAGNETIZATION transfer ,ANIMAL diseases ,FIBROSIS ,ANIMAL disease models - Abstract
In this study, we investigated the utility of native T
1 mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native T1 mapping and MTI were enrolled. The longitudinal relaxation time (T1 value) and normalized magnetization transfer ratio (MTR) were compared between none-to-mild and moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. The results showed that the correlation between the T1 value and fibrosis (r = 0.438, p < 0.001) was lower than that between the normalized MTR and fibrosis (r = 0.623, p < 0.001). Overall, the T1 values (t = −3.066, p = 0.004) and normalized MTRs (z = 0.081, p < 0.001) in none-to-mild fibrotic bowel walls were lower than those in moderate-to-severe fibrotic bowel walls. The area under the curve (AUC) of the T1 value (AUC = 0.716, p = 0.004) was significantly lower than that of the normalized MTR (AUC = 0.881, p < 0.001) in differentiating moderate-to-severe fibrosis from none-to-mild fibrosis (z = −2.037, p = 0.042). Our results support the view that the T1 value could be a promising imaging biomarker in grading the fibrosis severity of CD. However, the diagnostic performance of native T1 mapping was not superior to MTI. [ABSTRACT FROM AUTHOR] more...- Published
- 2021
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10. Development and Validation of a Novel Computed-Tomography Enterography Radiomic Approach for Characterization of Intestinal Fibrosis in Crohn's Disease.
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Li, Xuehua, Liang, Dong, Meng, Jixin, Zhou, Jie, Chen, Zhao, Huang, Siyun, Lu, Baolan, Qiu, Yun, Baker, Mark E., Ye, Ziyin, Cao, Qinghua, Wang, Mingyu, Yuan, Chenglang, Chen, Zhihui, Feng, Shengyu, Zhang, Yuxuan, Iacucci, Marietta, Ghosh, Subrata, Rieder, Florian, and Sun, Canhui more...
- Abstract
No reliable method for evaluating intestinal fibrosis in Crohn's disease (CD) exists; therefore, we developed a computed-tomography enterography (CTE)–based radiomic model (RM) for characterizing intestinal fibrosis in CD. This retrospective multicenter study included 167 CD patients with 212 bowel lesions (training, 98 lesions; test, 114 lesions) who underwent preoperative CTE and bowel resection at 1 of the 3 tertiary referral centers from January 2014 through June 2020. Bowel fibrosis was histologically classified as none–mild or moderate–severe. In the training cohort, 1454 radiomic features were extracted from venous-phase CTE and a machine learning–based RM was developed based on the reproducible features using logistic regression. The RM was validated in an independent external test cohort recruited from 3 centers. The diagnostic performance of RM was compared with 2 radiologists' visual interpretation of CTE using receiver operating characteristic (ROC) curve analysis. In the training cohort, the area under the ROC curve (AUC) of RM for distinguishing moderate–severe from none–mild intestinal fibrosis was 0.888 (95% confidence interval [CI], 0.818–0.957). In the test cohort, the RM showed robust performance across 3 centers with an AUC of 0.816 (95% CI, 0.706–0.926), 0.724 (95% CI, 0.526–0.923), and 0.750 (95% CI, 0.560–0.940), respectively. Moreover, the RM was more accurate than visual interpretations by either radiologist (radiologist 1, AUC = 0.554; radiologist 2, AUC = 0.598; both, P <. 001) in the test cohort. Decision curve analysis showed that the RM provided a better net benefit to predicting intestinal fibrosis than the radiologists. A CTE-based RM allows for accurate characterization of intestinal fibrosis in CD. [Display omitted] [ABSTRACT FROM AUTHOR] more...
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- 2021
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