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Your search keyword '"Charline Sazio"' showing total 3 results
Start Over Author "Charline Sazio" Topic critical care and intensive care medicine
3 results on '"Charline Sazio"'

1. Herpes Simplex Virus Encephalitis With Initial Negative Polymerase Chain Reaction in the Cerebrospinal Fluid: Prevalence, Associated Factors, and Clinical Impact

Author

Etienne, de Montmollin, Claire, Dupuis, Pierre, Jaquet, Benjamine, Sarton, Charline, Sazio, Vincent, Susset, Marie, Conrad, Laurent, Argaud, Sophie, Demeret, Jean Marc, Tadié, François, Barbier, Michel, Wolff, Jean-François, Timsit, Benoit, Visseaux, Romain, Sonneville, Guillaume, Franchineau, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, CHU Bordeaux [Bordeaux], Centre Hospitalier Métropole Savoie [Chambéry], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre Hospitalier Régional d'Orléans (CHRO), GHU Paris Psychiatrie et Neurosciences, Université Paris Cité (UPCité), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), ENCEPHALITICA Study Group: Julien Marechal, Bruno Mourvillier, Frederic Dailler, Fabrice Bruneel, Alexandre Lautrette, Emmanuel Novy, Bertrand Guidet, François Mateos, Clément Brault, Quentin Maestraggi, Keyvan Razazi, Jean-Pierre Quenot, Aurélie Joret, Albrice Levrat, Alexandre Massri, Alexandre Robert, Damien Contou, Jean-Paul Mira, Sarah Benghanem, Gaudry Stephane, Guillaume Voiriot, Asael Berger, Vincent Das, Nicolas Engrand, Martin Murgier, Shidasp Siami, Sami Hraiech, Eric Mariotte, Claire Ragot, Annabelle Stoclin, Pierre Trouiller, Mathieu Schmidt, Benjamin Rohaut, Guillaume Franchineau., CarMeN, laboratoire, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
[SDV] Life Sciences [q-bio], Critical Illness, [SDV]Life Sciences [q-bio], Prevalence, Acyclovir, Humans, Simplexvirus, Encephalitis, Herpes Simplex, Critical Care and Intensive Care Medicine, Polymerase Chain Reaction, Cerebrospinal Fluid
Abstract

International audience; OBJECTIVES: To describe the prevalence, associated factors, and clinical impact of an initial negative herpes simplex virus (HSV) polymerase chain reaction (PCR) in critically ill patients with PCR-proven HSV encephalitis. DESIGN: Retrospective multicenter study from 2007 to 2017. SETTING: Forty-seven French ICUs. PATIENTS: Critically ill patients admitted to the ICU with possible/probable acute encephalitis and a positive cerebrospinal fluid (CSF) PCR for HSV. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We included 273 patients with a median Glasgow Coma Scale score of 9 (6-12) at ICU admission. CSF HSV PCR was negative in 11 cases (4%), exclusively in lumbar punctures (LPs) performed less than 4 days after symptoms onset. Patients with an initial negative PCR presented with more frequent focal neurologic signs (4/11 [36.4%] vs 35/256 [13.7%]; p = 0.04) and lower CSF leukocytosis (4 cells/mm3 [3-25 cells/mm3] vs 52 cells/mm3 [12-160 cells/mm3]; p \textless 0.01). An initial negative PCR was associated with an increased delay between LP and acyclovir treatment (3 d [2-7 ] vs 0 d [0-0 d]; p \textless 0.01) and was independently associated with a poor neurologic outcome at hospital discharge (modified Rankin Scale score ≥ 4) (adjusted odds ratio, 9.89; 95% CI, 1.18-82.78). CONCLUSIONS: In severe herpes simplex encephalitis, initial negative CSF HSV PCR occurred in 4% of cases and was independently associated with worse neurologic outcome at hospital discharge. In these patients, a systematic multimodal diagnostic approach including early brain MRI and EEG will help clinicians avoid delayed acyclovir initiation or early inappropriate discontinuation.

Published
2022

2. Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study

Author

M. Alves, Noelle Brule, P. Jaquet, Frédérique Barbier, de Montmollin E, Da Silva D, Kalioubi Ae, Sâmea Keise de Oliveira Silva, Jean-Marc Tadié, Marie Conrad, Charline Sazio, Claire Dupuis, Pierre Bailly, Laurent Argaud, Susset, Michel Wolff, J. F. Timsit, Lila Bouadma, D. Daubin, Benjamine Sarton, Romain Sonneville, Sophie Demeret, R. Chabane, and Nicolas Lerolle

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Critical Care and Intensive Care Medicine, Logistic regression, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Modified Rankin Scale, Internal medicine, Anesthesiology, Outcome Assessment, Health Care, medicine, Humans, Aged, Retrospective Studies, Mechanical ventilation, Adult patients, business.industry, Glasgow Coma Scale, 030208 emergency & critical care medicine, Middle Aged, Physical Functional Performance, medicine.disease, Hospitalization, Intensive Care Units, 030228 respiratory system, Female, Encephalitis, Herpes Simplex, France, business, Encephalitis, Cohort study
Abstract

We aimed to study the association of body temperature and other admission factors with outcomes of herpes simplex encephalitis (HSE) adult patients requiring ICU admission. We conducted a retrospective multicenter study on patients diagnosed with HSE in 47 ICUs in France, between 2007 and 2017. Fever was defined as a body temperature higher or equal to 38.3 °C. Multivariate logistic regression analysis was used to identify factors associated with poor outcome at 90 days, defined by a score of 3–6 (indicating moderate-to-severe disability or death) on the modified Rankin scale. Overall, 259 patients with a score on the Glasgow coma scale of 9 (6–12) and a body temperature of 38.7 (38.1–39.2) °C at admission were studied. At 90 days, 185 (71%) patients had a poor outcome, including 44 (17%) deaths. After adjusting for age, fever (OR = 2.21; 95% CI 1.18–4.16), mechanical ventilation (OR = 2.21; 95% CI 1.21–4.03), and MRI brain lesions > 3 lobes (OR = 3.04; 95% CI 1.35–6.81) were independently associated with poor outcome. By contrast, a direct ICU admission, as compared to initial admission to the hospital wards (i.e., indirect ICU admission), was protective (OR = 0.52; 95% CI 0.28–0.95). Sensitivity analyses performed after adjustment for functional status before admission and reason for ICU admission yielded similar results. In HSE adult patients requiring ICU admission, several admission factors are associated with an increased risk of poor functional outcome. The identification of potentially modifiable factors, namely, elevated admission body temperature and indirect ICU admission, provides an opportunity for testing further intervention strategies.

Published
2019

3. Correction to: Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study

Author

Sâmea Keise de Oliveira Silva, V. Susset, Sophie Demeret, Claire Dupuis, Michel Wolff, Frédérique Barbier, Marie Conrad, A. El Kalioubi, M. Alves, Laurent Argaud, Romain Sonneville, P. Jaquet, D. Daubin, Daniel da Silva, R. Chabane, Noelle Brule, Nicolas Lerolle, Lila Bouadma, Pierre Bailly, E. De Montmollin, Jean-Marc Tadié, Charline Sazio, J. F. Timsit, and Benjamine Sarton

Subjects
Pediatrics, medicine.medical_specialty, Adult patients, business.industry, Pain medicine, Mistake, Critical Care and Intensive Care Medicine, medicine.disease, GeneralLiterature_MISCELLANEOUS, Anesthesiology, medicine, business, Encephalitis, Cohort study
Abstract

The original article unfortunately contained a mistake. Due to technical problems the study group was not tagged correctly. Please find the correct tagging down below. We apologize for the mistake.

Published
2019

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