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The field of tissue engineering involves various methodologies employed to improve or replace biological tissues with extracellular matrices (ECMs). Significant progress has been made, particularly in the fabrication of three-dimensional (3D) scaffolds for replacing damaged tissues or organs. The current review broadly focuses on the various research works carried out involving the use of biomaterials (biopolymers, bio-ceramics and dopants) in this area. A detailed discussion on several scaffold-making modern technologies has also been provided, along with a demonstration of different characterization techniques. Though a number of review papers have been published on biomaterials and fabrication techniques, a very small number focuses on the clinical trials carried out and the commercialization of scaffolds in the biomedical field. Thus, a critical analysis and detailed discussion of some of the clinical trials, market growth, and future demands have been presented in this paper. [ABSTRACT FROM AUTHOR]