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1. Adsorption performance of creatinine on dialdehyde nanofibrillated cellulose derived from potato residues.

Author

Cui D, Liu Z, Yang Y, Huang R, Cheng X, Fatehi P, and Sun B

Subjects
Adsorption, Cellulose chemical synthesis, Cellulose chemistry, Kinetics, Spectroscopy, Fourier Transform Infrared, Cellulose analogs & derivatives, Creatinine chemistry, Nanofibers chemistry, Solanum tuberosum chemistry
Abstract

Potato residue is vastly produced in the food industry but it is landfilled. This article describes the treatment of purified cellulose derived from potato residues by a high pressure homogenizer to produce nano-fibrillated cellulose (NFC), which was then oxidized by sodium periodate to prepare dialdehyde nano-fibrillated cellulose (DANFC). The produced NFC and DANFC were characterized by a scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). The orthogonal experiment was induced to obtain the maximum degree of oxidation (DO) on DANFC. The results indicated that the optimal conditions were 40°C and pH 3. Alternatively, the isotherm and kinetic studies for the adsorption of creatinine on DANFC with different DOs (70.5 and 88.8%) were investigated, and the experimental results fitted well into Freundlich isotherm model and pseudo second-order kinetic model. The maximum adsorption capacities of DANFCs with the DO of 70.55 and 88.85% were 6.7 and 17.2 mg g(-1) , respectively, which were achieved under the conditions of 37°C and initial creatinine concentration of 100 mg L(-1)., (© 2015 American Institute of Chemical Engineers.)

Published
2016
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2. Tacrolimus monotherapy in membranous nephropathy: A randomized controlled trial

Author

Praga, M., Barrio, V., Juárez, G. Fernández, Luño, J., and For the GRUPO ESPAÑOL DE ESTUDIO DE LA NEFROPATÍA MEMBRANOSA (Members of the Group listed at the end of the paper)

Subjects
medicine.medical_specialty, Creatinine, Proteinuria, nephrotic syndrome, business.industry, Urology, membranous nephropathy, Renal function, Spontaneous remission, medicine.disease, Tacrolimus, Surgery, law.invention, chemistry.chemical_compound, Membranous nephropathy, chemistry, Randomized controlled trial, Nephrology, law, medicine, medicine.symptom, tacrolimus, business, Nephrotic syndrome
Abstract

Membranous nephropathy is a common cause of nephrotic syndrome in adults. Although some patients with membranous nephropathy achieve a spontaneous remission, renal function continues to deteriorate in others. We conducted a prospective randomized trial evaluating monotherapy with tacrolimus to achieve complete or partial remission in patients with biopsy-proven membranous nephropathy. Twenty-five patients received tacrolimus (0.05mg/kg/day) over 12 months with a 6-month taper, whereas 23 patients were in the control group. The probability of remission in the treatment group was 58, 82, and 94% after 6, 12, and 18 months but only 10, 24, and 35%, respectively in the control group. The decrease in proteinuria was significantly greater in the treatment group. Notably, six patients in the control group and only one in the treatment group reached the secondary end point of a 50% increase in their serum creatinine. No patient in the tacrolimus group showed a relapse during the taper period. Nephrotic syndrome reappeared in almost half of the patients who were in remission by the 18th month after tacrolimus withdrawal. We conclude that tacrolimus is a very useful therapeutic option for patients with membranous nephropathy and preserved renal function. The majority of patients experienced remission with a significant reduction in the risk for deteriorating renal function.

Published
2007