17 results on '"Dunaway, David"'
Search Results
2. Sporting activity after craniosynostosis surgery in children: a source of parental anxiety
- Author
-
Rotimi, Oloruntobi, Jung, Gu-Yun Paul, Ong, Juling, Jeelani, N. U. Owase, Dunaway, David J., and James, Greg
- Published
- 2021
- Full Text
- View/download PDF
3. Statistical shape modelling to aid surgical planning: associations between surgical parameters and head shapes following spring-assisted cranioplasty
- Author
-
Rodriguez-Florez, Naiara, Bruse, Jan L., Borghi, Alessandro, Vercruysse, Herman, Ong, Juling, James, Greg, Pennec, Xavier, Dunaway, David J., Jeelani, N. U. Owase, and Schievano, Silvia
- Published
- 2017
- Full Text
- View/download PDF
4. Initial UK series of endoscopic suturectomy with postoperative helmeting for craniosynostosis: early report of perioperative experience.
- Author
-
Halim, Jonathan, Silva, Adikarige, Budden, Curtis, Dunaway, David J., Jeelani, N. U. Owase, Ong, Juling, and James, Greg
- Subjects
CRANIOSYNOSTOSES ,BLOOD products ,LENGTH of stay in hospitals ,SURGICAL complications ,HELMETS ,BLOOD platelet transfusion - Abstract
Endoscopic suturectomy with postoperative helmeting (ESCH) has emerged as a successful treatment for craniosynostosis, initially in North America. We report early outcomes from the first cohort of ESCH patients treated in the United Kingdom (UK). Retrospective cohort study with electronic chart review. 18 consecutive patients from the first ESCH procedure in UK (May 2017) until January 2020 identified. 12 male and 6 female infantsd, with a mean age of 4.6 months (range 2.5–7.8 months) and weight of 6.8 kg (range 4.8–9.8 kg). Diagnoses were metopic (n = 8), unicoronal (n = 7), sagittal (n = 2) and multi-sutural (n = 1) synostoses. Median incision length was 3 cm (range 2–10 cm). 16/18 received no blood products, with 2 (both metopics) requiring transfusion (1 donor exposure). Mean operative time (including anaesthesia) was 96 min (range 40–127 min). Median length of hospital stay was 1 night. 1 surgical complication (superficial infection). All patients are currently undergoing helmet orthosis therapy. So far, no patients have required revisional or squint surgery. Early experience from the first UK cohort of ESCH suggests that this is a safe and well tolerated technique with low morbidity, transfusion and short hospital stay. Long-term results in terms of shape, cosmetic and developmental outcome are awaited. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Correlation between head shape and volumetric changes following spring-assisted posterior vault expansion.
- Author
-
Ramdat Misier, Karan R.R., Breakey, Richard W.F., van de Lande, Lara S., Biffi, Benedetta, Knoops, Paul G.M., Schievano, Silvia, Caron, Cornelia J.J.M., Dunaway, David J., Koudstaal, Maarten J., Jeelani, N.U. Owase, and Borghi, Alessandro
- Subjects
PRINCIPAL components analysis ,COMPUTED tomography ,INTRACRANIAL pressure - Abstract
The aim of the study was to investigate whether different head shapes show different volumetric changes following spring-assisted posterior vault expansion (SA-PVE) and to investigate the influence of surgical and morphological parameters on SA-PVE. Preoperative three-dimensional skull models from patients who underwent SA-PVE were extracted from computed tomography scans. Patient head shape was described using statistical shape modelling (SSM) and principal component analysis (PCA). Preoperative and postoperative intracranial volume (ICV) and cranial index (CI) were calculated. Surgical and morphological parameters included skull bone thickness, number of springs, duration of spring insertion and type of osteotomy. In the analysis, 31 patients were included. SA-PVE resulted in a significant ICV increase (284.1 ± 171.6 cm
3 , p < 0.001) and a significant CI decrease (−2.9 ± 4.3%, p < 0.001). The first principal component was significantly correlated with change in ICV (Spearman ρ = 0.68, p < 0.001). Change in ICV was significantly correlated with skull bone thickness (ρ = −0.60, p < 0.001) and age at time of surgery (ρ = −0.60, p < 0.001). No correlations were found between the change in ICV and number of springs, duration of spring insertion and type of osteotomy. SA-PVE is effective for increasing the ICV and resolving raised intracranial pressure. Younger, brachycephalic patients benefit more from surgery in terms of ICV increase. Skull bone thickness seems to be a crucial factor and should be assessed to achieve optimal ICV increase. In contrast, insertion of more than two springs, duration of spring insertion or performing a fully cut through osteotomy do not seem to impact the ICV increase. When interpreting ICV increases, normal calvarial growth should be taken into account. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
6. Statistical shape modelling for the analysis of head shape variations.
- Author
-
Heutinck, Pam, Knoops, Paul, Florez, Naiara Rodriguez, Biffi, Benedetta, Breakey, William, James, Greg, Koudstaal, Maarten, Schievano, Silvia, Dunaway, David, Jeelani, Owase, and Borghi, Alessandro
- Subjects
STATISTICAL models ,PRINCIPAL components analysis ,MODE shapes ,ANATOMICAL variation ,STEREOSCOPIC photography - Abstract
The aim of this study is, firstly, to create a population-based 3D head shape model for the 0 to 2-year-old subjects to describe head shape variability within a normal population and, secondly, to test a combined normal and sagittal craniosynostosis (SAG) population model, able to provide surgical outcome assessment. 3D head shapes of patients affected by non-cranial related pathologies and of SAG patients (pre- and post-op) were extracted either from head CTs or 3D stereophotography scans, and processed. Statistical shape modelling (SSM) was used to describe shape variability using two models – a normal population model (MODEL1) and a combined normal and SAG population model (MODEL2). Head shape variability was described via principal components analysis (PCA) which calculates shape modes describing specific shape features. MODEL1 (n = 65) mode 1 showed statistical correlation (p < 0.001) with width (125.8 ± 13.6 mm), length (151.3 ± 17.4 mm) and height (112.5 ± 11.1 mm) whilst mode 2 showed correlation with cranial index (83.5 mm ± 6.3 mm, p < 0.001). The remaining 9 modes showed more subtle head shape variability. MODEL2 (n = 159) revealed that post-operative head shape still did not achieve full shape normalization with either spring cranioplasty or total calvarial remodelling. This study proves that SSM has the potential to describe detailed anatomical variations in a paediatric population. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
7. ERF‐related craniosynostosis: The phenotypic and developmental profile of a new craniosynostosis syndrome.
- Author
-
Glass, Graeme E., O'Hara, Justine, Canham, Natalie, Cilliers, Deirdre, Dunaway, David, Fenwick, Aimee L., Jeelani, Noor‐Owase, Johnson, David, Lester, Tracy, Lord, Helen, Morton, Jenny E. V., Nishikawa, Hiroshi, Noons, Peter, Schwiebert, Kemmy, Shipster, Caroleen, Taylor‐Beadling, Alison, Twigg, Stephen R. F., Vasudevan, Pradeep, Wall, Steven A., and Wilkie, Andrew O. M.
- Abstract
Mutations in the ERF gene, coding for ETS2 repressor factor, a member of the ETS family of transcription factors cause a recently recognized syndromic form of craniosynostosis (CRS4) with facial dysmorphism, Chiari‐1 malformation, speech and language delay, and learning difficulties and/or behavioral problems. The overall prevalence of ERF mutations in patients with syndromic craniosynostosis is around 2%, and 0.7% in clinically nonsyndromic craniosynostosis. Here, we present findings from 16 unrelated probands with ERF‐related craniosynostosis, with additional data from 20 family members sharing the mutations. Most of the probands exhibited multisutural (including pan‐) synostosis but a pattern involving the sagittal and lambdoid sutures (Mercedes‐Benz pattern) predominated. Importantly the craniosynostosis was often postnatal in onset, insidious and progressive with subtle effects on head morphology resulting in a median age at presentation of 42 months among the probands and, in some instances, permanent visual impairment due to unsuspected raised intracranial pressure (ICP). Facial dysmorphism (exhibited by all of the probands and many of the affected relatives) took the form of orbital hypertelorism, mild exorbitism and malar hypoplasia resembling Crouzon syndrome but, importantly, a Class I occlusal relationship. Speech delay, poor gross and/or fine motor control, hyperactivity and poor concentration were common. Cranial vault surgery for raised ICP and/or Chiari‐1 malformation was expected when multisutural synostosis was observed. Variable expressivity and nonpenetrance among genetically affected relatives was encountered. These observations form the most complete phenotypic and developmental profile of this recently identified craniosynostosis syndrome yet described and have important implications for surgical intervention and follow‐up. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
8. Cranial bone structure in children with sagittal craniosynostosis: Relationship with surgical outcomes.
- Author
-
Rodriguez-Florez, Naiara, Ibrahim, Amel, Hutchinson, J. Ciaran, Borghi, Alessandro, James, Greg, Arthurs, Owen J., Ferretti, Patrizia, Dunaway, David, Schievano, Silvia, and Jeelani, N. U. Owase
- Abstract
Summary Background While spring-assisted cranioplasty has become a widespread technique to correct scaphocephaly in children with sagittal synostosis, predicting head shape changes induced by the gradual opening of the springs remains challenging. This study aimed to explore the role of cranial bone structure on surgical outcomes. Methods Patients with isolated sagittal synostosis undergoing spring-assisted cranioplasty at GOSH (London, UK) were recruited (n = 18, age: 3–8 months). Surgical outcome was assessed by the change in cephalic index measured on 3D head scans acquired before spring insertion and after their removal using a 3D handheld scanner. Parietal bone samples routinely discarded during spring-assisted cranioplasty were collected and scanned using micro-computed tomography. From visual assessment of such scans, bone structure was classified into one- or three-layered, the latter indicating the existence of a diploë cavity. Bone average thickness, volume fraction and surface density were computed and correlated with changes in cephalic index. Results Cephalic index increased for all patients (p < 0.001), but individual improvement varied. Although the patient age and treatment duration were not significantly correlated with changes in cephalic index, bone structural parameters were. The increase of cephalic index was smaller with increasing bone thickness (Pearson's r = −0.79, p < 0.001) and decreasing bone surface density (r = 0.77, p < 0.001), associated with the three-layered bone structure. Conclusions Variation in parietal bone micro-structure was associated with the magnitude of head shape changes induced by spring-assisted cranioplasty. This suggests that bone structure analysis could be a valuable adjunct in designing surgical strategies that yield optimal patient-specific outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
9. Quantifying the effect of corrective surgery for trigonocephaly: A non-invasive, non-ionizing method using three-dimensional handheld scanning and statistical shape modelling.
- Author
-
Rodriguez-Florez, Naiara, Göktekin, Özge K., Bruse, Jan L., Borghi, Alessandro, Angullia, Freida, Knoops, Paul G.M., Tenhagen, Maik, O'Hara, Justine L., Koudstaal, Maarten J., Schievano, Silvia, Jeelani, N.U. Owase, James, Greg, and Dunaway, David J.
- Subjects
CRANIOSYNOSTOSES ,FRONTAL bone ,THREE-dimensional imaging ,PRINCIPAL components analysis ,HOSPITAL care ,NUMERICAL analysis ,DIAGNOSIS - Abstract
Trigonocephaly in patients with metopic synostosis is corrected by fronto-orbital remodelling (FOR). The aim of this study was to quantitatively assess aesthetic outcomes of FOR by capturing 3D forehead scans of metopic patients pre- and post-operatively and comparing them with controls. Ten single-suture metopic patients undergoing FOR and 15 age-matched non-craniosynostotic controls were recruited at Great Ormond Street Hospital for Children (UK). Scans were acquired with a three-dimensional (3D) handheld camera and post-processed combining 3D imaging software. 3D scans were first used for cephalometric measurements. Statistical shape modelling was then used to compute the 3D mean head shapes of the three groups (FOR pre-op, post-op and controls). Head shape variations were described via principal component analysis (PCA). Cephalometric measurements showed that FOR significantly increased the forehead volume and improved trigonocephaly. This improvement was supported visually by pre- and post-operative computed mean 3D shapes and numerically by PCA (p < 0.001). Compared with controls, post-operative scans showed flatter foreheads (p < 0.001). In conclusion, 3D scanning followed by 3D statistical shape modelling enabled the 3D comparison of forehead shapes of metopic patients and non-craniosynostotic controls, and demonstrated that the adopted FOR technique was successful in correcting bitemporal narrowing but overcorrected the rounding of the forehead. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
10. Aberrant facial flushing following monobloc fronto-facial distraction.
- Author
-
Cobb, Alistair R.M., Vourvachis, Michael, Ahmed, Jahangir, Wyatt, Michelle, Dunaway, David, and Hayward, Richard
- Subjects
FACIAL abnormalities ,CRANIOSYNOSTOSES ,EXOPHTHALMOS ,POSTOPERATIVE care ,PTERYGOPALATINE ganglion ,PATIENTS - Abstract
Background Patients with syndromic forms of craniosynostosis may experience functional problems such as raised intracranial pressure, proptosis, obstructive sleep apnoea and failure to thrive. The monobloc fronto-facial advancement with osteogenic distraction is increasingly used to correct these functional problems in one procedure as well as improve appearance. The authors report the phenomenon of post operative aberrant facial flushing – an unusual and previously unreported complication of the procedure. Methods The case notes of 80 consecutive patients undergoing fronto-facial advancement by distraction using the rigid external distraction device (RED) were reviewed for features of aberrant facial flushing. Results Four out of eighty individuals developed facial flushing after monobloc fronto-facial distraction using the rigid external distractor (RED) frame. All were female with Crouzon or Pfeiffer syndromes causing the severe functional problems for which they underwent the surgery. They were aged 6–8 years. Following removal of the frame, they developed intermittent but severe facial flushing. The flushing spontaneously settled in three patients after up to four years but persists in the other child seven years after her surgery. Conclusion Aberrant facial flushing is a rare but significant complication of monobloc fronto-facial surgery. It occurred in 4 of our 80 (5%) patients. The skull base osteotomies essential for the procedure are made anterior to the pterygopalatine ganglion and it is our contention that damage from these was responsible for a neuropraxia of its efferent nerve branches. A review of the autonomic control of the facial vascular system suggests that the phenomenon is due to an unequal process of recovery that leaves the cutaneous vasodilating parasympathetic or beta-adrenergic innervation relatively unopposed – a situation that persists until with time a normal balance of autonomic input is achieved. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
11. Describing Crouzon and Pfeiffer syndrome based on principal component analysis.
- Author
-
Staal, Femke C.R., Ponniah, Allan J.T., Angullia, Freida, Ruff, Clifford, Koudstaal, Maarten J., and Dunaway, David
- Subjects
CRANIOFACIAL dysostosis ,APERT syndrome ,CRANIOSYNOSTOSES ,GENETIC mutation ,FIBROBLAST growth factor receptors ,PRINCIPAL components analysis - Abstract
Crouzon and Pfeiffer syndrome are syndromic craniosynostosis caused by specific mutations in the FGFR genes. Patients share the characteristics of a tall, flattened forehead, exorbitism, hypertelorism, maxillary hypoplasia and mandibular prognathism. Geometric morphometrics allows the identification of the global shape changes within and between the normal and syndromic population. Methods Data from 27 Crouzon-Pfeiffer and 33 normal subjects were landmarked in order to compare both populations. With principal component analysis the variation within both groups was visualized and the vector of change was calculated. This model normalized a Crouzon-Pfeiffer skull and was compared to age-matched normative control data. Results PCA defined a vector that described the shape changes between both populations. Movies showed how the normal skull transformed into a Crouzon-Pfeiffer phenotype and vice versa. Comparing these results to established age-matched normal control data confirmed that our model could normalize a Crouzon-Pfeiffer skull. Conclusions PCA was able to describe deformities associated with Crouzon-Pfeiffer syndrome and is a promising method to analyse variability in syndromic craniosynostosis. The virtual normalization of a Crouzon-Pfeiffer skull is useful to delineate the phenotypic changes required for correction, can help surgeons plan reconstructive surgery and is a potentially promising surgical outcome measure. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
12. Mechanical and morphological properties of parietal bone in patients with sagittal craniosynostosis.
- Author
-
Ajami, Sara, Rodriguez-Florez, Naiara, Ong, Juling, Jeelani, Noor ul Owase, Dunaway, David, James, Greg, Angullia, Freida, Budden, Curtis, Bozkurt, Selim, Ibrahim, Amel, Ferretti, Patrizia, Schievano, Silvia, and Borghi, Alessandro
- Subjects
FINITE element method ,BONE mechanics ,SANDWICH construction (Materials) ,BONE density ,CRANIOSYNOSTOSES ,ELASTIC modulus - Abstract
Limited information is available on the effect of sagittal craniosynostosis (CS) on morphological and material properties of the parietal bone. Understanding these properties would not only provide an insight into bone response to surgical procedures but also improve the accuracy of computational models simulating these surgeries. The aim of the present study was to characterise the mechanical and microstructural properties of the cortical table and diploe in parietal bone of patients affected by sagittal CS. Twelve samples were collected from pediatric patients (11 males, and 1 female; age 5.2 ± 1.3 months) surgically treated for sagittal CS. Samples were imaged using micro-computed tomography (micro-CT); and mechanical properties were extracted by means of micro-CT based finite element modelling (micro-FE) of three-point bending test, calibrated using sample-specific experimental data. Reference point indentation (RPI) was used to validate the micro-FE output. Bone samples were classified based on their macrostructure as unilaminar or trilaminar (sandwich) structure. The elastic moduli obtained using RPI and micro-FE approaches for cortical tables (E RPI 3973.33 ± 268.45 MPa and E micro-FE 3438.11 ± 387.38 MPa) in the sandwich structure and diploe (E RPI 1958.17 ± 563.79 MPa and E micro-FE 1960.66 ± 492.44 MPa) in unilaminar samples were in strong agreement (r = 0.86, p <.01). We found that the elastic modulus of cortical tables and diploe were correlated with bone mineral density. Changes in the microstructure and mechanical properties of bone specimens were found to be irrespective of patients' age. Although younger patients are reported to benefit more from surgical intervention as skull is more malleable, understanding the material properties is critical to better predict the surgical outcome in patients <1 year old since age-related changes were minimal. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
13. Cranial bone microarchitecture in a mouse model for syndromic craniosynostosis.
- Author
-
Ajami, Sara, Van den Dam, Zoe, Hut, Julia, Savery, Dawn, Chin, Milton, Koudstaal, Maarten, Steacy, Miranda, Carriero, Alessandra, Pitsillides, Andrew, Chang, Y.‐M., Rau, Christoph, Marathe, Shashidhara, Dunaway, David, Jeelani, Noor Ul Owase, Schievano, Silvia, Pauws, Erwin, and Borghi, Alessandro
- Subjects
- *
FIBROBLAST growth factor receptors , *FIBROBLAST growth factor 2 , *FRONTAL bone , *CRANIAL sutures , *COMPACT bone , *BRACHYCEPHALY - Abstract
Crouzon syndrome is a congenital craniofacial disorder caused by mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2). It is characterized by the premature fusion of cranial sutures, leading to a brachycephalic head shape, and midfacial hypoplasia. The aim of this study was to investigate the effect of the FGFR2 mutation on the microarchitecture of cranial bones at different stages of postnatal skull development, using the FGFR2C342Y mouse model. Apart from craniosynostosis, this model shows cranial bone abnormalities. High‐resolution synchrotron microtomography images of the frontal and parietal bone were acquired for both FGFR2C342Y/+ (Crouzon, heterozygous mutant) and FGFR2+/+ (control, wild‐type) mice at five ages (postnatal days 1, 3, 7, 14 and 21, n = 6 each). Morphometric measurements were determined for cortical bone porosity: osteocyte lacunae and canals. General linear model to assess the effect of age, anatomical location and genotype was carried out for each morphometric measurement. Histological analysis was performed to validate the findings. In both groups (Crouzon and wild‐type), statistical difference in bone volume fraction, average canal volume, lacunar number density, lacunar volume density and canal volume density was found at most age points, with the frontal bone generally showing higher porosity and fewer lacunae. Frontal bone showed differences between the Crouzon and wild‐type groups in terms of lacunar morphometry (average lacunar volume, lacunar number density and lacunar volume density) with larger, less dense lacunae around the postnatal age of P7–P14. Histological analysis of bone showed marked differences in frontal bone only. These findings provide a better understanding of the pathogenesis of Crouzon syndrome and will contribute to computational models that predict postoperative changes with the aim to improve surgical outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Towards a radiation free numerical modelling framework to predict spring assisted correction of scaphocephaly.
- Author
-
Garate Andikoetxea, Begona, Ajami, Sara, Rodriguez-Florez, Naiara, Jeelani, N. U. Owase, Dunaway, David, Schievano, Silvia, and Borghi, Alessandro
- Abstract
Abstract\nUNSTRUCTURED ABSTRACTSagittal Craniosynostosis (SC) is a congenital craniofacial malformation, involving premature sagittal suture ossification; spring-assisted cranioplasty (SAC) – insertion of metallic distractors for skull reshaping – is an established method for treating SC. Surgical outcomes are predictable using numerical modelling, however published methods rely on computed tomography (CT) scans availability, which are not routinely performed. We investigated a simplified method, based on radiation-free 3D stereophotogrammetry scans.Eight SAC patients (age 5.1 ± 0.4 months) with preoperative CT and 3D stereophotogrammetry scans were included. Information on osteotomies, spring model and post-operative spring opening were recorded. For each patient, two preoperative models (PREOP) were created: i) CT model and ii) S model, created by processing patient specific 3D surface scans using population averaged skin and skull thickness and suture locations. Each model was imported into ANSYS Mechanical (Analysis System Inc., Canonsburg, PA) to simulate spring expansion. Spring expansion and cranial index (CI - skull width over length) at times equivalent to immediate postop (POSTOP) and follow up (FU) were extracted and compared with in-vivo measurements.Overall expansion patterns were very similar for the 2 models at both POSTOP and FU. Both models had comparable outcomes when predicting spring expansion. Spring induced CI increase was similar, with a difference of 1.2%±0.8% for POSTOP and 1.6%±0.6% for FU.This work shows that a simplified model created from the head surface shape yields acceptable results in terms of spring expansion prediction. Further modelling refinements will allow the use of this predictive tool during preoperative planning.Spring-assisted cranioplasty (SAC) –insertion of metallic distractors helping skull reshaping – is a method for treating sagittal craniosynostosis, caused by premature sagittal suture closure. We present a method for predicting SAC outcomes, relying on radiation-free 3D stereophotogrammetry scans. Eight patients with preoperative CT and 3D stereophotogrammetry scans were recruited; results of spring expansion simulation were compared between models created using CT versus 3D scan data. Expansion patterns and extent of reshaping were very similar. This work proves that SAC preoperative planning can be carried out using non-ionising imaging. Further modelling refinements will allow clinical adoption of this predictive tool. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
15. Unilateral isolated frontosphenoidal craniosynostosis causing frontal plagiocephaly.
- Author
-
Marucci, Damian D., Jones, Barry M., Dunaway, David J., and Hayward, Richard D.
- Subjects
CRANIOSYNOSTOSES ,CASE studies ,CHILDREN ,MEDICAL radiology ,SKULL abnormalities ,CRANIOLOGY ,DIAGNOSIS ,ANTHROPOMETRY - Abstract
Summary: Synostotic frontal plagiocephaly is most commonly caused by frontoparietal (unicoronal) synostosis, but may be caused by other fusions along the coronal hemiring. Frontosphenoidal synostosis is a rare cause of frontal plagiocephaly, with only five previously reported cases. We present the case of an 8-month-old male infant with frontal plagiocephaly caused by unilateral isolated frontosphenoidal synostosis mimicking frontoparietal (unicoronal) synostosis. The clinical and radiological features included flattened ipsilateral forehead, retruded ipsilateral maxilla, a midline chin, contralateral deviation of the nasal root and endocranial base, and anomalies of the bony orbit. Unilateral isolated frontosphenoidal synostosis may be misdiagnosed as unicoronal synostosis. Careful physical and radiological assessment is necessary to recognise this synostotic disorder of the coronal hemiring. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
- View/download PDF
16. Spring assisted cranioplasty: A patient specific computational model.
- Author
-
Borghi, Alessandro, Rodriguez-Florez, Naiara, Rodgers, Will, James, Gregory, Hayward, Richard, Dunaway, David, Jeelani, Owase, and Schievano, Silvia
- Subjects
- *
FINITE element method , *BIOMECHANICS , *MEDICAL imaging systems , *THREE-dimensional imaging , *COMPUTED tomography , *COMPUTER-assisted image analysis (Medicine) - Abstract
Implantation of spring-like distractors in the treatment of sagittal craniosynostosis is a novel technique that has proven functionally and aesthetically effective in correcting skull deformities; however, final shape outcomes remain moderately unpredictable due to an incomplete understanding of the skull-distractor interaction. The aim of this study was to create a patient specific computational model of spring assisted cranioplasty (SAC) that can help predict the individual overall final head shape. Pre-operative computed tomography images of a SAC patient were processed to extract a 3D model of the infant skull anatomy and simulate spring implantation. The distractors were modeled based on mechanical experimental data. Viscoelastic bone properties from the literature were tuned using the specific patient procedural information recorded during surgery and from x-ray measurements at follow-up. The model accurately captured spring expansion on-table (within 9% of the measured values), as well as at first and second follow-ups (within 8% of the measured values). Comparison between immediate post-operative 3D head scanning and numerical results for this patient proved that the model could successfully predict the final overall head shape. This preliminary work showed the potential application of computational modeling to study SAC, to support pre-operative planning and guide novel distractor design. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
17. Validation of an in-silico modelling platform for outcome prediction in spring assisted posterior vault expansion.
- Author
-
Deliège, Lara, Misier, Karan Ramdat, Bozkurt, Selim, Breakey, William, James, Greg, Ong, Juling, Dunaway, David, Jeelani, N.U. Owase, Schievano, Silvia, and Borghi, Alessandro
- Subjects
- *
PREOPERATIVE care , *SKULL , *FINITE element method , *RETROSPECTIVE studies , *HEALTH outcome assessment , *DIAGNOSTIC imaging , *CRANIOSYNOSTOSES , *DESCRIPTIVE statistics , *POSTOPERATIVE period , *COMPUTED tomography - Abstract
Spring-Assisted Posterior Vault Expansion has been adopted at Great Ormond Street Hospital for Children, London, UK to treat raised intracranial pressure in patients affected by syndromic craniosynostosis, a congenital calvarial anomaly which causes premature fusion of skull sutures. This procedure aims at normalising head shape and augmenting intracranial volume by means of metallic springs which expand the back portion of the skull. The aim of this study is to create and validate a 3D numerical model able to predict the outcome of spring cranioplasty in patients affected by syndromic craniosynostosis, suitable for clinical adoption for preoperative surgical planning. Retrospective spring expansion measurements retrieved from x-ray images of 50 patients were used to tune the skull viscoelastic properties for syndromic cases. Pre-operative computed tomography (CT) data relative to 14 patients were processed to extract patient-specific skull shape, replicate surgical cuts and simulate spring insertion. For each patient, the predicted finite element post-operative skull shape model was compared with the respective post-operative 3D CT data. The comparison of the sagittal and transverse cross-sections of the simulated end-of-expansion calvaria and the post-operative skull shapes extracted from CT images showed a good shape matching for the whole population. The finite element model compared well in terms of post-operative intracranial volume prediction (R2 = 0.92, p < 0.0001). These preliminary results show that Finite Element Modelling has great potential for outcome prediction of spring assisted posterior vault expansion. Further optimisation will make it suitable for clinical deployment. • A patient-specific spring-assisted posterior vault expansion model is proposed. • The model captures the intracranial volume augmentation due to skull viscoelastic adaptation. • The finite element model is validated using post-operative computed tomography scans. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.